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Tod Fullston et al.
Journal of assisted reproduction and genetics, 32(5), 725-735 (2015-04-10)
To investigate the impacts that a paternal high fat diet (HFD) has on embryology, ovarian/cumulus cell gene expression and COC metabolism from female offspring, using a mouse model. Founder male mice were either fed a control diet (CD) or a
Sheng Jin et al.
Oxidative medicine and cellular longevity, 2015, 758358-758358 (2015-06-17)
Aims. To examine whether hydrogen sulfide (H2S) generation changed in ageing diabetic mouse hearts. Results. Compared to mice that were fed tap water only, mice that were fed 30% fructose solution for 15 months exhibited typical characteristics of a severe
Mahmoud Benltifa et al.
Bioorganic & medicinal chemistry, 17(20), 7368-7380 (2009-09-29)
A series of glucopyranosylidene-spiro-isoxazolines was prepared through regio- and stereoselective [3+2]-cycloaddition between the methylene acetylated exo-glucal and aromatic nitrile oxides. The deprotected cycloadducts were evaluated as inhibitors of muscle glycogen phosphorylase b. The carbohydrate-based family of five inhibitors displays K(i)
C B Christiansen et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(7), 537-543 (2015-01-21)
TLQP-21 is a VGF-derived neuropeptide proposed to be involved in regulation of metabolism. More specifically it has been suggested that TLQP-21 has the ability to enhance glucose stimulated insulin secretion, making it a candidate for treatment of patients with type
A M Onyshchenko et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 61(6), 22-28 (2000-03-25)
Availability of certain monosaccharides in the composition of glycocalyx of lactic acid bacteria (Lactobacillus plantarum--strains 337D and 11/16; Streptococcus thermophilus--strains S1 (nonmucous race) and S5 (mucous race), Enterococcus faecium (K-50) has been investigated with the help of plant lectins with
Lourdes Robles et al.
PloS one, 9(9), e107111-e107111 (2014-09-10)
Chronic pancreatitis (CP) is a progressive disorder resulting in the destruction and fibrosis of the pancreatic parenchyma which ultimately leads to impairment of the endocrine and exocrine functions. Dimethyl Fumarate (DMF) was recently approved by FDA for treatment of patients
Yuko Maejima et al.
Neuroendocrinology, 101(1), 35-44 (2015-01-13)
Recent studies have considered oxytocin (Oxt) as a possible medicine to treat obesity and hyperphagia. To find the effective and safe route for Oxt treatment, we compared the effects of its nasal and intraperitoneal (IP) administration on food intake, locomotor
S R Dalmau et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 22(5), 601-610 (1989-01-01)
1. Three assays were used to test nine sugars for inhibition of jacalin activity prepared from Artocarpus integrifolia. Rat spleen proliferation was unsuitable since the measurement of the effects of sugars against jacalin binding was complicated by their simultaneous metabolic
Matias Knuuttila et al.
The American journal of pathology, 184(8), 2163-2173 (2014-06-21)
Androgens are key factors involved in the development and progression of prostate cancer (PCa), and PCa growth can be suppressed by androgen deprivation therapy. In a considerable proportion of men receiving androgen deprivation therapy, however, PCa progresses to castration-resistant PCa
Toru Kimura et al.
The Journal of surgical research, 194(2), 631-637 (2014-12-09)
C-type natriuretic peptide (CNP), secreted by vascular endothelial cells, belongs to a family of peptides that includes atrial and brain natriuretic peptides. CNP exhibits many vasoprotective effects against pulmonary hypertension and pulmonary fibrosis. The objective of this study was to
Yuki Osawa et al.
International journal of oncology, 46(3), 1252-1258 (2015-01-13)
Carbonyl reductase 1 (CBR1) expression level is related to tumor progression. Decreased CBR1 expression is associated with poor prognosis in ovarian cancer. We investigated the relationship between CBR1 expression level and malignant potential of ovarian cancer. OVCAR‑3 cells overexpressing CBR1
Ana Rita Costa et al.
eLife, 9 (2020-03-21)
Neurons have a membrane periodic skeleton (MPS) composed of actin rings interconnected by spectrin. Here, combining chemical and genetic gain- and loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network that controls axonal expansion
Annelien Van Dalem et al.
Diabetologia, 58(12), 2753-2764 (2015-09-28)
We examined whether measures of glycaemic variability (GV), assessed by continuous glucose monitoring (CGM) and self-monitoring of blood glucose (SMBG), can complement or replace measures of beta cell function and insulin action in detecting the progression of preclinical disease to
Peter Halvorsen et al.
Upsala journal of medical sciences, 120(1), 11-19 (2015-02-04)
Our aim was to investigate cerebral and cardiac tissue injury subsequent to use of vasopressin and adrenaline in combination compared with vasopressin alone during cardiopulmonary resuscitation (CPR). In a randomized, prospective, laboratory animal study 28 anesthetized piglets were subject to
David Reinhart et al.
Applied microbiology and biotechnology, 99(11), 4645-4657 (2015-04-08)
In this study, eight commercially available, chemically defined Chinese hamster ovary (CHO) cell culture media from different vendors were evaluated in batch culture using an IgG-producing CHO DG44 cell line as a model. Medium adaptation revealed that the occurrence of
Vicky G Tsirkone et al.
Bioorganic & medicinal chemistry, 18(10), 3413-3425 (2010-05-01)
Design of inhibitors of glycogen phosphorylase (GP) with pharmaceutical applications in improving glycaemic control in type 2 diabetes is a promising therapeutic strategy. The catalytic site of muscle glycogen phosphorylase b (GPb) has been probed with five deoxy-fluro-glucose derivatives. These
S Georgiou et al.
Gerontology, 51(3), 155-160 (2005-04-16)
The results of the very few histochemical studies that have been performed so far on the lectin-binding profile of normal human epidermis are mostly controversial; thus, the carbohydrate residue composition of the cell surface in the latter still remains in
Takuya Suzuki et al.
International journal of pharmaceutics, 476(1-2), 205-212 (2014-10-05)
We recently demonstrated that Doxil loses its long-circulating properties when injected repeatedly at doses below 2 mg/m(2) in dogs. In studies using other animal species, PEGylated liposomal doxorubicin has been reported not to induce the accelerated blood clearance (ABC) phenomenon.
J C Shaw et al.
Journal of developmental origins of health and disease, 6(3), 250-260 (2015-02-11)
Modulation of gamma-aminobutyric acid A (GABAA) receptor signalling by the neurosteroid allopregnanolone has a major role in late gestation neurodevelopment. The objective of this study was to characterize the mRNA levels of GABAA receptor subunits (α4, α5, α6 and δ)
Khine Myint et al.
PloS one, 10(7), e0130727-e0130727 (2015-07-02)
The platinum-based anticancer drug oxaliplatin is important clinically in cancer treatment. However, the role of multidrug resistance-associated protein 2 (MRP2) in controlling oxaliplatin membrane transport, in vivo handling, toxicity and therapeutic responses is unclear. In the current study, preparations of
Toru Kimura et al.
Cancer chemotherapy and pharmacology, 75(5), 1057-1063 (2015-03-31)
Cisplatin is a highly effective chemotherapeutic agent used to treat various malignancies, but its utility is compromised by its nephrotoxicity. C-type natriuretic peptide (CNP), a member of the natriuretic peptide family, exhibits anti-inflammatory effects by activating its specific receptor, guanylyl
Rui-Rong Tan et al.
Nutrients, 7(8), 6567-6581 (2015-08-12)
Gestational diabetes mellitus (GDM) is one of the leading causes of offspring malformations, in which eye malformation is an important disease. It has raised demand for therapy to improve fetal outcomes. In this study, we used chick embryo to establish
Yiu Ki Mok et al.
Applied biochemistry and biotechnology, 176(6), 1564-1580 (2015-05-20)
Accurate protein quantification is necessary in many of the steps during the enzymatic hydrolysis of pretreated lignocellulosic biomass, from the fundamental determination of enzyme kinetics to techno-economic assessments, such as the use of enzyme recycling strategies, evaluation of enzyme costs
Anna Ermund et al.
Clinical and experimental pharmacology & physiology, 42(1), 69-75 (2014-10-15)
Hypertonic saline inhalation has become a cornerstone in the treatment of cystic fibrosis (CF), but its effect on CF mucus is still not understood. In CF, mucus stagnates in the airways, causing mucus plugging, and forming a substrate for bacterial
Nevena Ivanovic et al.
Food & function, 6(2), 558-565 (2014-12-19)
In this study, two Lactobacillus strains (L. rhamnosus LA68 and L. plantarum WCFS1) were evaluated for their effects on high fat diet induced pathology in mice. The aim was to determine whether the administration of lactic acid bacteria had beneficial
A Azau et al.
Perfusion, 29(6), 496-504 (2014-03-13)
We hypothesized that the optimization of renal haemodynamics by maintaining a high level of mean arterial blood pressure (MAP) during cardiopulmonary bypass (CPB) could reduce the rate of acute kidney injury (AKI) in high-risk patients. In this randomized, controlled study
Edyta Maslak et al.
Biochemical pharmacology, 93(3), 389-400 (2014-12-24)
There is an unmet medical need for novel NAFLD treatments. Here we have examined the effects of liver-selective NO donor (V-PYRRO/NO) as compared with metformin on hepatic steatosis and glucose tolerance in mice fed high fat diet. Effects of V-PYRRO/NO
Chunling Wu et al.
Cell transplantation, 24(5), 891-907 (2014-05-20)
Genetically engineered stem cells that overexpress genes encoding therapeutic products can be exploited to correct metabolic disorders by repairing and regenerating diseased organs or restoring their function. Hair follicles are readily accessible and serve as a rich source of autologous
Katarzyna Linder et al.
The Journal of clinical endocrinology and metabolism, 100(11), 4029-4036 (2015-10-16)
Gestational diabetes (GDM) influences the fetal phenotype. In the present study, our aim was to determine the effect of GDM specifically on fetal brain activity. Pregnant participants underwent an oral glucose tolerance test (OGTT, 75 g). At 0, 60, and
Kitt Falk Petersen et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(36), 11330-11334 (2015-08-26)
Previous studies have implicated age-associated reductions in mitochondrial oxidative phosphorylation activity in skeletal muscle as a predisposing factor for intramyocellular lipid (IMCL) accumulation and muscle insulin resistance (IR) in the elderly. To further investigate potential alterations in muscle mitochondrial function
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