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Cátia Carreira et al.
Applied and environmental microbiology, 81(6), 2149-2155 (2015-01-18)
Viral abundances in benthic environments are the highest found in aquatic systems. Photosynthetic microbial mats represent benthic environments with high microbial activity and possibly high viral densities, yet viral abundances have not been examined in such systems. Existing extraction procedures
Lisa M Parsons et al.
PloS one, 9(10), e107250-e107250 (2014-10-09)
Caenorabditis elegans bus-4 glycosyltransferase mutants are resistant to infection by Microbacterium nematophilum, Yersinia pestis and Yersinia pseudotuberculosis and have altered susceptibility to two Leucobacter species Verde1 and Verde2. Our objective in this study was to define the glycosylation changes leading
Wolfram Föllmann et al.
Journal of toxicology and environmental health. Part A, 75(19-20), 1206-1215 (2012-09-22)
N-Acetyltransferases (NAT) are important enzymes in the metabolism of certain carcinogenic arylamines, as N-acetylation decreases or prevents their bioactivation via N-hydroxylation. To study such processes in the bladder, cell culture models may be used, but metabolic competence needs to be
Tonglei Wu et al.
FEMS microbiology letters, 362(12), fnv078-fnv078 (2015-05-10)
Copper is a potent antimicrobial agent. Multiple mechanisms of copper tolerance are utilized by some pathogenic bacteria. BMEII0580, which is significantly similar to the multicopper oxidase from Escherichia coli, was predicted to be the probable blue copper protein YacK precursor
Hayato Nishida et al.
Regulatory toxicology and pharmacology : RTP, 72(3), 578-585 (2015-06-07)
Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic ingredients, such as plant extracts and polymers, could not be evaluated because their molecular weight
Daniela Carlos et al.
Frontiers in immunology, 11, 1265-1265 (2020-08-11)
Type 2 diabetes (T2D) is a metabolic disease characterized by increased inflammation, NOD-like receptors (NLRs) activation and gut dysbiosis. Our research group has recently reported that intestinal Th17 response limits gut dysbiosis and LPS translocation to visceral adipose tissue (VAT)
Yalda Shoja et al.
Materials science & engineering. C, Materials for biological applications, 58, 835-845 (2015-10-20)
A novel and selective enzymatic biosensor was designed and constructed for voltammetric determination of levodopa (L-Dopa) in aqueous media (phosphate buffer solution, pH=7). Biosensor development was on the basis of to physically immobilizing of horse radish peroxidase (HRP) as electrochemical
Niku Oksala et al.
Atherosclerosis, 242(1), 145-154 (2015-07-21)
Kindlins (FERMT) are cytoplasmic proteins required for integrin (ITG) activation, leukocyte transmigration, platelet aggregation and thrombosis. Characterization of kindlins and their association with atherosclerotic plaques in human(s) is lacking. Exploratory microarray (MA) was first performed followed by selective quantitative validation
R Brans et al.
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 60(1), 26-31 (2008-12-23)
Due to its constant exposure to small molecular weight compounds, the skin is a major target for allergic reactions. Para-phenylenediamine (PPD) is a common and strong contact allergen. Recent studies have revealed new aspects of steps involved in sensitization and
York Rudhard et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 2927-2941 (2015-02-24)
Axon degeneration is a programed process that takes place during development, in response to neuronal injury, and as a component of neurodegenerative disease pathology, yet the molecular mechanisms that drive this process remain poorly defined. In this study, we have
Abel T Demissie et al.
Journal of the American Chemical Society, 137(27), 8819-8828 (2015-06-23)
We report the systematic characterization of anisotropic, π-conjugated oligophenyleneimine (OPI) films synthesized using stepwise imine condensation, or "click" chemistry. Film synthesis began with a self-assembled monolayer (SAM) of 4-formylthiophenol or 4-aminothiophenol on Au, followed by repetitive, alternate addition of terephthalaldehyde
Lauren LaBerge et al.
Dermatitis : contact, atopic, occupational, drug, 22(6), 332-334 (2012-06-02)
p-Phenylenediamine (PPD) is an important allergen; 5.0% of patients tested positive to PPD when patch-tested, according to the North American Contact Dermatitis Group. Hair dyes are the main source of exposure. To assess the significance of PPD allergy at the
A Luna-Acosta et al.
The Science of the total environment, 514, 511-522 (2015-02-11)
Contaminant effects on defence responses of ecologically and economically important organisms, such as the Pacific oyster Crassostrea gigas, are likely to influence their ability to resist infectious diseases, particularly at the young stages. The aim of this study was to
Laura Malinauskiene et al.
Contact dermatitis, 67(3), 130-140 (2012-05-26)
It is known that, in vitro, human skin bacteria are able to split disperse azo dyes into the corresponding aromatic amines, some of which are sensitizers in the local lymph node assay. We hypothesize that the molecules of disperse dyes
Unusual localization of allergic contact dermatitis from p-phenylenediamine.
Andrea Bassi et al.
Dermatitis : contact, atopic, occupational, drug, 22(6), 358-358 (2012-06-02)
Yanala Sandeep Reddy et al.
Renal failure, 34(7), 880-884 (2012-06-12)
We studied paraphenylenediamine (PPD)-related acute kidney injury (AKI) in 81 patients and also in albino rats experimentally. In the patients' group AKI was found in 32.7%. Of them, 81.4% needed dialysis support. The overall mortality was 25.9%. In experimental rats
T Kojima et al.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 21(3), 295-301 (2014-10-18)
In oxidative coloring, the hair cuticle layers are not only the penetration pathway for active ingredients but also one of the most important dyeing regions. The dyeing mechanism of oxidative dyes in fine structures of the cuticle remains unclear. To
John Manwaring et al.
Toxicology and applied pharmacology, 287(2), 139-148 (2015-06-02)
Approaches to assess the role of absorption, metabolism and excretion of cosmetic ingredients that are based on the integration of different in vitro data are important for their safety assessment, specifically as it offers an opportunity to refine that safety
Fabiola Kind et al.
Pediatrics, 131(6), e1974-e1976 (2013-05-22)
Allergic contact dermatitis from nonpermanent black henna tattoos has been frequently reported, particularly in children. Contamination or adulteration of the dyes with para-phenylendiamine has been identified as major cause of active sensitization and elicitation of severe allergic contact dermatitis. Sequelae
Studies on thermal and mechanical properties of polyimide-clay nanocomposites
Agag T, et al.
Polymer, 42(8), 3399-3408 (2001)
Alejandra Bosco et al.
Disease models & mechanisms, 8(5), 443-455 (2015-03-11)
Microglia serve key homeostatic roles, and respond to neuronal perturbation and decline with a high spatiotemporal resolution. The course of all chronic CNS pathologies is thus paralleled by local microgliosis and microglia activation, which begin at early stages of the
Sara Dominguez et al.
Cell death and differentiation, 28(3), 915-931 (2020-10-01)
RIP1 kinase is proposed to play a critical role in driving necroptosis and inflammation in neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS). Preclinical studies indicated that while pharmacological inhibition of RIP1 kinase can ameliorate axonal pathology and delay disease onset
Giovanni Rizzo et al.
PloS one, 7(11), e50230-e50230 (2012-12-05)
Leber's hereditary optic neuropathy (LHON) is characterized by retinal ganglion cell (RGC) degeneration with the preferential involvement of those forming the papillomacular bundle. The optic nerve is considered the main pathological target for LHON. Our aim was to investigate the
Feng Guo et al.
PloS one, 9(10), e109267-e109267 (2014-10-11)
Repetitive transcranial magnetic stimulation (rTMS) has increasingly been studied over the past decade to determine whether it has a therapeutic benefit on focal cerebral ischemia. However, the underlying mechanism of rTMS in this process remains unclear. In the current study
Bram Baert et al.
Bioorganic & medicinal chemistry, 15(22), 6943-6955 (2007-09-11)
A set of 116 structurally very diverse compounds, mainly drugs, was characterized by 1630 molecular descriptors. The biological property modelled in this study was the transdermal permeability coefficient logK(p). The main objective was to find a limited set of suitable
Brock G Bennion et al.
Cell reports, 31(11), 107771-107771 (2020-06-20)
STING gain-of-function causes autoimmunity and immunodeficiency in mice and STING-associated vasculopathy with onset in infancy (SAVI) in humans. Here, we report that STING gain-of-function in mice prevents development of lymph nodes and Peyer's patches. We show that the absence of
Kaori Kojima et al.
Neuroscience letters, 581, 37-41 (2014-08-26)
p62, which is also called sequestosome 1 (SQSTM1), plays a critical role in neuronal cell death. However, the role of p62 in axonal degeneration remains unclear. We evaluated whether the modulation of p62 expression may affect axonal loss in tumor
Ryan J Lopez et al.
Bioelectrochemistry (Amsterdam, Netherlands), 105, 78-87 (2015-05-27)
Pyrroloquinoline quinone dependent soluble glucose dehydrogenase (PQQ-sGDH) enzymatic MWCNT electrodes were p roduced using 1-pyrenecarboxylic acid (PCA) activated through carbodiimide functionalization and 1-Pyrenebutyric acid N-hydroxysuccinimide ester (PBSE) as tethering agents. At 600 mV potential, the current density generated by the
Sharon A Williams et al.
Molecular cancer, 9, 250-250 (2010-09-21)
A growing body of work implicates chemokines, in particular CXCL12 and its receptors, in the progression and site-specific metastasis of various cancers, including breast cancer. Various agents have been used to block the CXCL12-CXCR4 interaction as a means of inhibiting
Thomas Milinkovitch et al.
Aquatic toxicology (Amsterdam, Netherlands), 161, 170-175 (2015-02-24)
Although the variegated scallop Mimachlamys varia seems to be a suitable sentinel species for contaminant monitoring, no study has identified biomarkers in this species. In order to fill this gap, this study conducted an in situ biomarker approach. M. varia
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