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Lori S Tillmans et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 24(4), 713-719 (2015-02-05)
Cigarette smoking (smoking), hormone therapy (MHT), and folate intake (folate) are each thought to influence colorectal cancer risk, but the underlying molecular mechanisms remain incompletely defined. Expression of estrogen receptor β (ESR2) has been associated with colorectal cancer stage and
Viola B Morris et al.
Biomaterials, 60, 151-160 (2015-05-23)
Neuronal gene therapy potentially offers an effective therapeutic intervention to cure or slow the progression of neurological diseases. However, neuronal cells are difficult to transfect with nonviral vectors, and in vivo their transport across the blood-brain barrier (BBB) is inefficient. We
Mohamad Abu-Abied et al.
Journal of experimental botany, 66(9), 2813-2824 (2015-03-20)
Induction of adventitious roots (ARs) in recalcitrant plants often culminates in cell division and callus formation rather than root differentiation. Evidence is provided here to suggest that microtubules (MTs) play a role in the shift from cell division to cell
Chih-Yuan Ko et al.
Psychoneuroendocrinology, 55, 173-183 (2015-03-17)
Social isolation rearing (SIR) is an early stress paradigm of deprivation of the social contact since weaning. SIR has been used to investigate the mechanisms behind certain mental illnesses with neurodevelopmental origins, including schizophrenia. In schizophrenia, metabolic dysfunction has become
Diletta Scaccabarozzi et al.
PloS one, 10(12), e0143195-e0143195 (2015-12-02)
Malaria-associated acute lung injury (MA-ALI) and its more severe form malaria-associated acute respiratory distress syndrome (MA-ARDS) are common, often fatal complications of severe malaria infections. However, little is known about their pathogenesis. In this study, biochemical alterations of the lipid
Fangfang Ma et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(47), 16967-16972 (2014-11-05)
Improving plant productivity is an important aim for metabolic engineering. There are few comprehensive methods that quantitatively describe leaf metabolism, although such information would be valuable for increasing photosynthetic capacity, enhancing biomass production, and rerouting carbon flux toward desirable end
Troy J Pereira et al.
The Journal of physiology, 593(14), 3181-3197 (2015-04-30)
Maternal obesity is associated with a high risk for gestational diabetes mellitus (GDM), which is a common complication of pregnancy. The influence of maternal obesity and GDM on the metabolic health of the offspring is poorly understood. We hypothesize that
S Chometton et al.
Journal of chemical neuroanatomy, 61-62, 72-82 (2014-08-16)
Neurons producing melanin-concentrating hormone (MCH) or hypocretin/orexin (Hcrt) have been implicated in the sleep/wake cycle and feeding behavior. Sleep and feeding habits vary greatly among mammalian species, depending in part of the prey/predatory status of animals. However, the distribution of
Maryam Zamanian-Daryoush et al.
The Journal of biological chemistry, 295(15), 4836-4848 (2020-02-27)
Apolipoprotein A-I (apoA-I) is the major protein constituent of high-density lipoprotein (HDL) and a target of myeloperoxidase-dependent oxidation in the artery wall. In atherosclerotic lesions, apoA-I exhibits marked oxidative modifications at multiple sites, including Trp72 Site-specific mutagenesis studies have suggested
Pei-Hong Fan et al.
Journal of the science of food and agriculture, 95(11), 2228-2236 (2014-10-02)
As probiotics, soy oligosaccharides have become popular as healthy foods to reduce disease risk. However, comprehensive information about oligosaccharides in different food legumes is limited. In this study, eight oligosaccharides were well detected and quantified in different varieties of eight
R Imbert et al.
Human reproduction (Oxford, England), 29(9), 1931-1940 (2014-06-25)
Do the benefits of ovarian tissue cryopreservation outweigh the risks for patients seeking to preserve fertility before gonadotoxic treatment in various indications? In >90% of the patients undergoing cryopreservation of ovarian tissue, oncological treatment was associated with a reduced ovarian
Naoki Tanaka et al.
Biochimica et biophysica acta, 1852(7), 1242-1252 (2015-03-05)
Fibroblast growth factor 21 (FGF21) is a modulator of energy homeostasis and is increased in human nonalcoholic liver disease (NAFLD) and after feeding of methionine- and choline-deficient diet (MCD), a conventional inducer of murine nonalcoholic steatohepatitis (NASH). However, the significance
Humberto Riera et al.
PloS one, 10(5), e0127571-e0127571 (2015-05-23)
Pyrrolidine dithiocarbamate (PDTC) known as antioxidant and specific inhibitor of NF-κB was also described as pro-oxidant by inducing cell death and reactive oxygen species (ROS) accumulation in cancer. However, the mechanism by which PDTC indices its pro-oxidant effect is unknown.
Joana E Matos et al.
Reproductive biology and endocrinology : RB&E, 13, 60-60 (2015-06-13)
In cryopreservation, oocytes are subjected to extreme hyperosmotic conditions, inducing large volume changes that, along with an abrupt temperature drop, interfere with their developmental competence. Our objectives in this work were to find conditions enabling an increase in oocyte cryosurvival
Nianli Liu et al.
Virology, 462-463, 283-294 (2014-07-08)
Newcastle disease virus (NDV) oncolysis is believed to be facilitated by a defective Type I interferon (IFN) response. We compared hepatocellular carcinoma (HCC)-derived cell lines and found that TRAIL-resistant cells were more susceptible to NDV oncolysis than were TRAIL-sensitive cells.
David Goyer et al.
The European journal of neuroscience, 41(11), 1416-1429 (2015-04-24)
In the avian nucleus magnocellularis (NM) endbulb of Held giant synapses develop from temporary bouton terminals. The molecular regulation of this process is not well understood. Furthermore, it is unknown how the postsynaptic specialization of the endbulb synapses develops. We
Christelle Durand et al.
Pain, 156(8), 1465-1476 (2015-04-19)
Each year, millions of people worldwide are treated for primary or recurrent pelvic malignancies, involving radiotherapy in almost 50% of cases. Delayed development of visceral complications after radiotherapy is recognized in cancer survivors. Therapeutic doses of radiation may lead to
Fang Wu et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(12), 1966-1976 (2015-07-02)
The active zone (AZ) is a thickening of the presynaptic membrane where exocytosis takes place. Chemical synapses contain neurotransmitter-loaded synaptic vesicles (SVs) that at rest are tethered away from the synaptic release site, but after the presynaptic inflow of Ca(+2)
Claudio Parolo et al.
Nature protocols, 15(12), 3788-3816 (2020-10-25)
Lateral-flow assays (LFAs) are quick, simple and cheap assays to analyze various samples at the point of care or in the field, making them one of the most widespread biosensors currently available. They have been successfully employed for the detection
Akie Shimotohno et al.
Plant & cell physiology, 56(4), 620-630 (2015-02-12)
Boron, an essential micronutrient, is transported in roots of Arabidopsis thaliana mainly by two different types of transporters, BORs and NIPs (nodulin26-like intrinsic proteins). Both are plasma membrane localized, but have distinct transport properties and patterns of cell type-specific accumulation
Kirsten Allan et al.
FEBS letters, 588(20), 3739-3743 (2014-08-31)
Expression of human amyloid-β (Aβ) in Drosophila is frequently used to investigate its toxicity in vivo. We expressed Aβ1-42 in the fly using a secretion signal derived from the Drosophila necrotic gene, as described in several previous publications. Surface-enhanced laser
Yoko Yazaki-Sugiyama et al.
The European journal of neuroscience, 41(1), 97-108 (2014-10-30)
Genetically targeted approaches that permit acute and reversible manipulation of neuronal circuit activity have enabled an unprecedented understanding of how discrete neuronal circuits control animal behavior. Zebra finch singing behavior has emerged as an excellent model for studying neuronal circuit
Rosanne E Casu et al.
Plant molecular biology, 89(6), 607-628 (2015-10-13)
Sugarcane (Saccharum spp. hybrids) accumulates high concentrations of sucrose in its mature stalk and a considerable portion of carbohydrate metabolism is also devoted to cell wall synthesis and fibre production. We examined tissue-specific expression patterns to explore the spatial deployment
Monika Petersson et al.
Nature communications, 6, 5874-5874 (2015-01-23)
Epithelial cancer constitutes a major clinical challenge and molecular mechanisms underlying the process of tumour initiation are not well understood. Here we demonstrate that hair follicle bulge stem cells (SCs) give rise to well-differentiated sebaceous tumours and show that SCs
Yusuke Tarumoto et al.
The Journal of biological chemistry, 288(26), 19260-19268 (2013-05-15)
General amino acid control (GAAC) is crucial for sensing and adaptation to nutrient availability. Amino acid starvation activates protein kinase Gcn2, which plays a central role in the GAAC response by phosphorylating the α-subunit of eukaryotic initiation factor 2 (eIF2α)
Yong-Il Kim et al.
Archives of pharmacal research, 38(12), 2163-2171 (2015-07-18)
In this study, the enteric-coated delayed-release pellets of duloxetine hydrochloride (DLX) were formulated using a fluidized bed coater. Three separate layers, the drug layer, the barrier layer, and the enteric layer, were coated onto inert core pellets. Among the three
Ju-Young Kim et al.
Drug development and industrial pharmacy, 41(2), 292-299 (2013-11-21)
The purpose of the present study was to prepare desmopressin orally disintegrating microparticles (ODMs) using organic-aqueous crossover coating process which featured an organic sub-coating followed by an aqueous active coating. Sucrose beads and hydroxypropyl cellulose (HPC) were used as inert
U Taschler et al.
British journal of pharmacology, 172(17), 4419-4429 (2015-06-16)
Monoglyceride lipase (MGL) degrades 2-arachidonoyl glycerol (2-AG), an endogenous agonist of cannabinoid receptors (CB1/2 ). Because the CB1 receptor is involved in the control of gut function, we investigated the effects of pharmacological inhibition and genetic deletion of MGL on
Katharina Tondera et al.
International journal of hygiene and environmental health, 218(8), 731-741 (2015-10-04)
Fecal contamination of water resources is a major public health concern in densely populated areas since these water bodies are used for drinking water production or recreational purposes. A main source of this contamination originates from combined sewer overflows (CSOs)
Lynne S Cairns et al.
Journal of bacteriology, 196(12), 2216-2226 (2014-04-08)
The assembly of the bacterial flagellum is exquisitely controlled. Flagellar biosynthesis is underpinned by a specialized type III secretion system that allows export of proteins from the cytoplasm to the nascent structure. Bacillus subtilis regulates flagellar assembly using both conserved
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