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Elimination of vitamin D receptor in vascular endothelial cells alters vascular function.
Ni W, Watts SW, Ng M, et al.
Hypertension, 64(6), 1290-1298 (2014)
Kazutaka Kamiya et al.
American journal of ophthalmology, 158(1), 179-184 (2014-04-05)
To evaluate the factors affecting the long-term regression after posterior chamber phakic intraocular lens (Visian ICL; STAAR Surgical) implantation for myopia. Retrospective observational case series. We retrospectively examined 60 eyes of 35 consecutive patients (age, 38.4 ± 9.3 years [mean
Jing-Yi Jeng et al.
The Journal of physiology, 599(1), 269-287 (2020-11-13)
Age-related hearing loss is a progressive hearing loss involving environmental and genetic factors, leading to a decrease in hearing sensitivity, threshold and speech discrimination. We compared age-related changes in inner hair cells (IHCs) between four mouse strains with different levels
Jiung-Pang Huang et al.
Journal of cardiovascular pharmacology, 72(5), 231-241 (2018-11-07)
We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for 17 weeks. Mice developed type 2
Panagiotis Laspas et al.
Experimental eye research, 127, 1-8 (2014-07-16)
Nitric oxide synthases (NOS) are involved in regulation of ocular vascular tone and blood flow. While endothelial NOS (eNOS) has recently been shown to mediate endothelium-dependent vasodilation in mouse retinal arterioles, the contribution of individual NOS isoforms to vascular responses
Acetylcholine-evoked afterdischarge in Aplysia bag cell neurons
White SH and Magoski NS
American Journal of Physiology. Heart and Circulatory Physiology (2012)
Brittany G Durgin et al.
JCI insight, 4(19) (2019-09-06)
Nitric oxide regulates BP by binding the reduced heme iron (Fe2+) in soluble guanylyl cyclase (sGC) and relaxing vascular smooth muscle cells (SMCs). We previously showed that sGC heme iron reduction (Fe3+ → Fe2+) is modulated by cytochrome b5 reductase
Thiago Bruder-Nascimento et al.
Clinical science (London, England : 1979), 128(7), 411-423 (2014-11-02)
Oxidative stress [increased bioavailability of reactive oxygen species (ROS)] plays a role in the endothelial dysfunction and vascular inflammation, which underlie vascular damage in diabetes. Statins are cholesterol-lowering drugs that are vasoprotective in diabetes through unknown mechanisms. We tested the
Samuel Legeay et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 127, 110200-110200 (2020-05-18)
Diabetes notably increases the risk for endothelial dysfunction, a main precursor for microvascular complications. While endoplasmic reticulum stress (ERS) and protein tyrosine phosphatase 1B (PTP1B) have been associated with endothelial dysfunction in resistance vessels, whether these mechanisms also contribute to
Fredrik Iredahl et al.
Microcirculation (New York, N.Y. : 1994), 22(6), 446-453 (2015-05-29)
After iontophoresis of vasoactive drugs into the skin, a decrease in perfusion is commonly observed. We delivered vaso-active drugs by iontophoresis using different delivery protocols to study how these affect this decrease in perfusion as measured using LDF. We measured
Wei Mee Loh et al.
Vascular pharmacology, 71, 151-158 (2015-04-15)
Des-aspartate angiotensin I (DAA-I), an endogenous nonapeptide, counteracts several effects of angiotensin II on vascular tone. The aim of this study was to investigate the acute protective effect of DAA-I on endothelial function in the spontaneously hypertensive rat (SHR) as
Wengang Wang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(25), 10405-10426 (2013-06-21)
Locomotion and cue-dependent behaviors are modified through corticostriatal signaling whereby short-term increases in dopamine availability can provoke persistent changes in glutamate release that contribute to neuropsychiatric disorders, including Parkinson's disease and drug dependence. We found that withdrawal of mice from
Qing Cao et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 23(14), 1797-1805 (2016-12-04)
Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicine for promoting intelligence and tranquilization. Polygalasaponins extracted from the root of P. tenuifolia possess evident anxiolytic and sedative-hypnotic activities. Previous studies have reported
Ya-Bin Tang et al.
Analytica chimica acta, 849, 70-79 (2014-10-11)
Dynamic, continuous, and simultaneous multi-analysis of transmitters is important for the delineation of the complex interactions between the neuronal and intercellular communications. But the analysis of the whole repertoire of classical transmitters of diverse structure is challenging due to their
Rogier B Poorthuis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4843-4853 (2013-03-15)
Adolescence is a period in which the developing prefrontal cortex (PFC) is sensitive to maladaptive changes when exposed to nicotine. Nicotine affects PFC function and repeated exposure to nicotine during adolescence impairs attention performance and impulse control during adulthood. Nicotine
Yeh Siang Lau et al.
Nutrients, 7(7), 5239-5253 (2015-07-03)
Botanical herbs are consumed globally not only as an essential diet but also as medicines or as functional/recreational food supplements. The extract of the Apocynum venetum leaves (AVLE), also known as Luobuma, exerts its antihypertensive effect via dilating the blood
A Altomare et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(1), G77-G88 (2014-05-17)
It has been shown, in animal models, that gastrointestinal tract (GIT) motility is influenced by temperature; nevertheless, the basic mechanism governing thermal GIT smooth muscle responses has not been fully investigated. Studies based on physiologically tuned mathematical models have predicted
Manuel A Ramírez-Lee et al.
Toxicology letters, 224(2), 246-256 (2013-11-06)
Silver nanoparticles (AgNPs) are used to manufacture materials with new properties and functions. However, little is known about their toxic or beneficial effects on human health, especially in the respiratory system, where its smooth muscle (ASM) regulates the airway contractility
Belthrand Habiyakare et al.
International journal of experimental pathology, 95(4), 290-295 (2014-06-24)
Novel treatments are necessary to reduce the burden of cardiovascular disease (CVD). Alamandine binds to MrgD and is reported to induce vasodilation via stimulation of endothelial nitric oxide synthase (eNOS), but its role in atherogenic blood vessels is yet to
Pragya Komal et al.
The Journal of physiology, 593(16), 3513-3532 (2015-05-21)
Protein kinases can modify the function of many proteins including ion channels. However, the role of protein kinase A in modifying nicotinic receptors in the CNS has never been investigated. We showed through whole-cell recordings of layer 1 prefrontal cortical interneurons that
Saikat Ray et al.
Science (New York, N.Y.), 343(6173), 891-896 (2014-01-25)
Little is known about how microcircuits are organized in layer 2 of the medial entorhinal cortex. We visualized principal cell microcircuits and determined cellular theta-rhythmicity in freely moving rats. Non-dentate-projecting, calbindin-positive pyramidal cells bundled dendrites together and formed patches arranged
Y X Sun et al.
Journal of tropical pediatrics, 60(2), 141-147 (2013-12-18)
To determine the response of nebulized magnesium sulfate on the lung function of acetylcholine-induced asthma children. Three hundred and thirty children of asthma with positive bronchial provocation test were randomly divided into three groups: magnesium sulfate, albuterol, and a combination
Mariko Sekiguchi-Tonosaki et al.
American journal of physiology. Cell physiology, 296(5), C1195-C1206 (2009-02-27)
Retinal pigmented epithelial cells exchange their cellular phenotypes into lens cells and neurons, via depigmented and non-epithelial-shaped dedifferentiated intermediates. Because these dedifferentiated cells can either revert to pigmented epithelial cells or transdifferentiate into lens cells and/or neurons, they are recognized
Markus H Hillert et al.
Journal of neurochemistry, 131(1), 42-52 (2014-06-10)
The lithium-pilocarpine model is a rat model of epilepsy that mimics status epilepticus in humans. Here, we report changes of acetylcholine (ACh) release in the hippocampus before, during and after status epilepticus as monitored by microdialysis in unanesthetized rats. Administration
Stelina Drimousis et al.
The Journal of pharmacology and experimental therapeutics, 375(1), 28-39 (2020-08-09)
The tachykinin NK2 receptor plays a key role in gastrointestinal motor function. Enteric neurons release neurokinin A (NKA), which activates NK2 receptors on gastrointestinal smooth muscle, leading to contraction and increased motility. In patients with diarrhea-predominant irritable bowel syndrome, the
Amber Hanif Palla et al.
Journal of ethnopharmacology, 160, 61-68 (2014-11-30)
Linum usitatissimum, commonly known as Flaxseed has traditionally been used for the management of diarrhea and gastrointestinal infections. This study was planned to assess pharmacological basis for the medicinal use of Flaxseed in infectious and non-infectious diarrhea. The crude aqueous-methanolic
Dalise Zancheta et al.
Life sciences, 122, 78-86 (2014-12-24)
This study aimed to evaluate the effects of Wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), on aortic hyporeactivity to Phenylephrine (Phe) and nitric oxide bioavailability associated with pregnancy in hypertensive rats. The intact aortic rings of pregnant
Qu Nie et al.
Life sciences, 232, 116662-116662 (2019-07-20)
Vascular endothelial cells act as a selective barrier between circulating blood and vessel wall and play an important role in the occurrence and development of cardiovascular diseases. Astragaloside IV (As-IV) has a protective effect on vascular endothelial cells, but its
Valerie Wolters et al.
Molecular pharmacology, 87(1), 9-17 (2014-10-16)
G-protein-coupled receptor kinase 2 (GRK2) is a serine/threonine kinase with an important function in the desensitization of G-protein-coupled receptors. Based on its ability to bind G-protein βγ subunits as well as activated Gαq subunits, it can be considered as an
Y Zhang et al.
Journal of neurophysiology, 124(5), 1377-1387 (2020-08-28)
Olivocochlear neurons make temporary cholinergic synapses on inner hair cells of the rodent cochlea in the first 2 to 3 wk after birth. Repetitive stimulation of these efferent neurons causes facilitation of evoked release and increased spontaneous release that continues
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