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Lie Wang et al.
Journal of neurophysiology, 113(3), 754-767 (2014-11-08)
The perinuclear zone (PNZ) of the supraoptic nucleus (SON) contains some GABAergic and cholinergic neurons thought to innervate the SON proper. In mice expressing enhanced green fluorescent protein (eGFP) in association with glutamate decarboxylase (GAD)65 we found an abundance of
Ashley M Chen et al.
Frontiers in neuroanatomy, 15, 629244-629244 (2021-06-08)
Manipulation of the phosphatase and tensin homolog (PTEN) pathway has been suggested as a therapeutic approach to treat or prevent vision loss due to retinal disease. In this study, we investigated the effects of deleting one copy of Pten in
Jin Li et al.
Scientific reports, 8(1), 13577-13577 (2018-09-13)
We recently reported that R-spondin 2 (Rspo2), a secreted activator of Wnt/β-catenin signaling, promotes acetylcholine receptor (AChR) clustering and neuromuscular junction (NMJ) formation via its receptor, Lgr5. Rspo2 is expressed highly in spinal motor neurons (SMNs) and marginally in the
Magali Cabanas et al.
PloS one, 12(9), e0184580-e0184580 (2017-09-22)
Hereditary Huntington's disease (HD) is associated with progressive motor, cognitive and psychiatric symptoms. A primary consequence of the HD mutation is the preferential loss of medium spiny projection cells with relative sparing of local interneurons in the striatum. In addition
Morphology, projection pattern, and neurochemical identity of Cajal's "centrifugal neurons": the cells of origin of the tectoventrogeniculate pathway in pigeon (Columba livia) and chicken (Gallus gallus).
Vega-Zuniga, T; Mpodozis, J; Karten, HJ; Marin, G; Hain, S; Luksch, H
The Journal of Comparative Neurology null
Michael L Risner et al.
Molecular neurodegeneration, 16(1), 36-36 (2021-06-07)
Early challenges to axonal physiology, active transport, and ultrastructure are endemic to age-related neurodegenerative disorders, including those affecting the optic nerve. Chief among these, glaucoma causes irreversible vision loss through sensitivity to intraocular pressure (IOP) that challenges retinal ganglion cell
Cindy F Yang et al.
Frontiers in neuroanatomy, 14, 58-58 (2020-10-06)
The key driver of breathing rhythm is the preBötzinger Complex (preBötC) whose activity is modulated by various functional inputs, e.g., volitional, physiological, and emotional. While the preBötC is highly interconnected with other regions of the breathing central pattern generator (bCPG)
Hiroshi Kida et al.
Scientific reports, 7(1), 12032-12032 (2017-09-22)
Rett syndrome (RTT) is a neurodevelopmental disorder mainly caused by mutations in the gene encoding the transcriptional regulator Methyl-CpG-binding protein 2 (MeCP2), located on the X chromosome. Many RTT patients have breathing abnormalities, such as apnea and breathing irregularity, and
Tyler W Stradleigh et al.
The Journal of comparative neurology, 519(13), 2546-2573 (2011-04-02)
The current-passing pore of mammalian hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels is formed by subunit isoforms denoted HCN1-4. In various brain areas, antibodies directed against multiple isoforms bind to single neurons, and the current (I(h)) passed during hyperpolarizations differs from that
Barbara Celona et al.
eLife, 6 (2017-01-11)
Expanded GGGGCC repeats in the first intron of the C9orf72 gene represent the most common cause of familial amyotrophic lateral sclerosis (ALS), but the mechanisms underlying repeat-induced disease remain incompletely resolved. One proposed gain-of-function mechanism is that repeat-containing RNA forms
Matthew J Gastinger et al.
The Journal of comparative neurology, 495(6), 658-667 (2006-03-01)
Mammalian retinas are innervated by histaminergic axons that originate from perikarya in the posterior hypothalamus. To identify the targets of these retinopetal axons, we localized histamine receptors (HR) in monkey and rat retinas by light and electron microscopy. In monkeys
Plasticity of motor network and function in the absence of corticospinal projection
Han Q, et al.
Experimental Neurology, 194-208 (2015)
Yuko Kataoka et al.
The Journal of comparative neurology, 518(3), 277-291 (2009-11-27)
Corticobasal ganglia neuronal ensembles bring automatic motor skills into voluntary control and integrate them into ongoing motor behavior. A 5% decrease in caudate (Cd) nucleus volume is the most consistent structural finding in the brain of patients with Tourette syndrome
Santiago Milla-Navarro et al.
International journal of molecular sciences, 22(12) (2021-07-03)
One of the causes of nervous system degeneration is an excess of glutamate released upon several diseases. Glutamate analogs, like N-methyl-DL-aspartate (NMDA) and kainic acid (KA), have been shown to induce experimental retinal neurotoxicity. Previous results have shown that NMDA/KA
Lester Torres Cadenas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(3), 509-525 (2019-11-14)
Medial olivocochlear (MOC) efferent neurons in the brainstem comprise the final stage of descending control of the mammalian peripheral auditory system through axon projections to the cochlea. MOC activity adjusts cochlear gain and frequency tuning, and protects the ear from
Ji-Yoen Kim et al.
Human molecular genetics, 25(21), 4661-4673 (2017-02-09)
Four mutations in the VAMP/synaptobrevin-associated protein B (VAPB) gene have been linked to amyotrophic lateral sclerosis (ALS) type 8. The mechanism by which VAPB mutations cause motor neuron disease is unclear, but studies of the most common P56S variant suggest
Xue Lou et al.
Medical science monitor : international medical journal of experimental and clinical research, 24, 2210-2217 (2018-04-14)
BACKGROUND The cardiac autonomic nervous system plays a crucial role in genesis and development of atrial fibrillation (AF) through the G protein signal transduction pathway. Therefore, intervening in the G protein signal transduction pathway may be a new "selective drug"
Nichole L Beebe et al.
Hearing research, 388, 107896-107896 (2020-01-27)
The development of knockin mice with Cre recombinase expressed under the control of the promoter for choline acetyltransferase (ChAT) has allowed experimental manipulation of cholinergic circuits. However, currently available ChATCre mouse lines are on the C57BL/6J strain background, which shows
Nicole L Reitz et al.
Frontiers in behavioral neuroscience, 15, 772857-772857 (2021-11-09)
Heavy alcohol consumption followed by periods of abstinence (i.e., binge drinking) during adolescence is a concern for both acute and chronic health issues. Persistent brain damage after adolescent intermittent ethanol exposure in rodents, a model of binge drinking, includes reduced
Zachary A Abecassis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(4), 743-768 (2019-12-08)
Within the basal ganglia circuit, the external globus pallidus (GPe) is critically involved in motor control. Aside from Foxp2+ neurons and ChAT+ neurons that have been established as unique neuron types, there is little consensus on the classification of GPe
Ritchie Ho et al.
Nature neuroscience, 19(9), 1256-1267 (2016-07-19)
Modeling amyotrophic lateral sclerosis (ALS) with human induced pluripotent stem cells (iPSCs) aims to reenact embryogenesis, maturation and aging of spinal motor neurons (spMNs) in vitro. As the maturity of spMNs grown in vitro compared to spMNs in vivo remains
Aurélie Flaive et al.
Journal of neurophysiology, 123(6), 2326-2342 (2020-05-14)
Serotoninergic (5-HT) neurons are powerful modulators of spinal locomotor circuits. Most studies on 5-HT modulation focused on the effect of exogenous 5-HT and these studies provided key information about the cellular mechanisms involved. Less is known about the effects of
Katherine R Brimblecombe et al.
eNeuro, 5(5) (2018-11-09)
Striatal dopamine (DA) is a major player in action selection and reinforcement. DA release is under strong local control by striatal ACh acting at axonal nicotinic ACh receptors (nAChRs) on DA axons. Striatal nAChRs have been shown to control how
Zongbing Hao et al.
Nature communications, 10(1), 2906-2906 (2019-07-04)
A GGGGCC hexanucleotide repeat expansion in intron 1 of chromosome 9 open reading frame 72 (C9ORF72) gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Repeat-associated non-ATG translation of dipeptide repeat proteins (DPRs) contributes
Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons.
Duque, S; Joussemet, B; Riviere, C; Marais, T; Dubreil, L; Douar, AM; Fyfe, J; Moullier et al.
Molecular Therapy null
Tanya Calvey et al.
Journal of chemical neuroanatomy, 72, 34-52 (2016-01-03)
The organization of the cholinergic, catecholaminergic, and serotonergic neurons in the brains of five species of insectivores and the orexinergic (hypocretinergic) system in four insectivore species is presented. We aimed to investigate the nuclear complement of these neural systems in
Pamela Jarrett et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 45(2), 150-157 (2018-03-07)
Neuronal ceroid-lipofuscinoses are a heterogeneous group of inherited disorders in which abnormal lipopigments form lysosomal inclusion bodies in neurons. Kufs disease is rare, and clinical symptoms include seizures, progressive cognitive impairment, and myoclonus. Most cases of Kufs disease are autosomal
Saak V Ovsepian et al.
Journal of neurophysiology, 108(2), 406-418 (2012-04-13)
Spontaneous firing and behavior-related changes in discharge profiles of basal forebrain (BF) neurons are well documented, albeit the mechanisms underlying the variety of activity modes and intermodal transitions remain elusive. With the use of cell-attached recordings, this study identifies a
Characterization of thoracic motor and sensory neurons and spinal nerve roots in canine degenerative myelopathy, a potential disease model of amyotrophic lateral sclerosis.
Morgan, BR; Coates, JR; Johnson, GC; Shelton, GD; Katz, ML
Journal of Neuroscience Research null
Emmanuel Che Ngwa et al.
Frontiers in neuroanatomy, 8, 2-2 (2014-02-28)
The oculomotor nucleus (nIII) contains the motoneurons of medial, inferior, and superior recti (MR, IR, and SR), inferior oblique (IO), and levator palpebrae (LP) muscles. The delineation of motoneuron subgroups for each muscle is well-known in monkey, but not in
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