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Lie Wang et al.
Journal of neurophysiology, 113(3), 754-767 (2014-11-08)
The perinuclear zone (PNZ) of the supraoptic nucleus (SON) contains some GABAergic and cholinergic neurons thought to innervate the SON proper. In mice expressing enhanced green fluorescent protein (eGFP) in association with glutamate decarboxylase (GAD)65 we found an abundance of
Erika Coletto et al.
NPJ Parkinson's disease, 7(1), 9-9 (2021-01-23)
The pathological changes underlying gastrointestinal (GI) dysfunction in Parkinson's disease (PD) are poorly understood and the symptoms remain inadequately treated. In this study we compared the functional and neurochemical changes in the enteric nervous system in the colon of adult
Tao He et al.
PloS one, 12(4), e0175522-e0175522 (2017-04-26)
Major histocompatibility complex (MHC) class I molecules and their receptors play fundamental roles in neuronal death during diseases. T-cell receptors (TCR) function as MHCI receptor on T-cells and both MHCI and a key component of TCR, CD3ζ, are expressed by
Anders Enjin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(23), 5634-5647 (2017-05-10)
When activating muscles, motor neurons in the spinal cord also activate Renshaw cells, which provide recurrent inhibitory feedback to the motor neurons. The tight coupling with motor neurons suggests that Renshaw cells have an integral role in movement, a role
Plasticity of motor network and function in the absence of corticospinal projection
Han Q, et al.
Experimental Neurology, 194-208 (2015)
Jing-Yi Jeng et al.
The Journal of physiology, 598(18), 3891-3910 (2020-07-02)
Age-related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure). Currently, we know very little about age-related changes occurring in the auditory sensory cells, including those associated with the
Yuko Kataoka et al.
The Journal of comparative neurology, 518(3), 277-291 (2009-11-27)
Corticobasal ganglia neuronal ensembles bring automatic motor skills into voluntary control and integrate them into ongoing motor behavior. A 5% decrease in caudate (Cd) nucleus volume is the most consistent structural finding in the brain of patients with Tourette syndrome
Tomomi Ichinose et al.
The Journal of physiology, 594(4), 883-894 (2015-11-11)
Using whole-cell clamp methods, we characterized the temporal coding in each type of OFF bipolar cell. We found that type 2 and 3a cells are transient, type 1 and 4 cells are sustained, and type 3b cells are intermediate. The
Jeffrey D Moore et al.
PLoS biology, 13(9), e1002253-e1002253 (2015-09-24)
Active sensing involves the fusion of internally generated motor events with external sensation. For rodents, active somatosensation includes scanning the immediate environment with the mystacial vibrissae. In doing so, the vibrissae may touch an object at any angle in the
M Morawski et al.
Neuroscience, 165(3), 831-849 (2009-08-18)
The Madagascan tenrecs (Afrotheria), an ancient mammalian clade, are characterized by unique brain anatomy. Striking features are an expanded paleocortex but a small and poorly differentiated neocortex devoid of a distinct granular layer IV. To investigate the organization of cortical
Viviana Triaca et al.
Aging cell, 15(4), 661-672 (2016-04-15)
NGF has been implicated in forebrain neuroprotection from amyloidogenesis and Alzheimer's disease (AD). However, the underlying molecular mechanisms are still poorly understood. Here, we investigated the role of NGF signalling in the metabolism of amyloid precursor protein (APP) in forebrain
Serena Riccitelli et al.
Cells, 10(6) (2021-07-03)
Retinal neurodegeneration can impair visual perception at different levels, involving not only photoreceptors, which are the most metabolically active cells, but also the inner retina. Compensatory mechanisms may hide the first signs of these impairments and reduce the likelihood of
Gina M Fernandez et al.
Neuroscience, 361, 129-143 (2017-08-16)
Adolescence has been identified as a vulnerable developmental time period during which exposure to drugs can have long-lasting, detrimental effects. Although adolescent binge-like ethanol (EtOH) exposure leads to a significant reduction in forebrain cholinergic neurons, EtOH's functional effect on acetylcholine
Preponderance of inhibitory versus excitatory intramuscular nerve fibres in human chagasic megacolon.
Samir Jabari,Alexandre B M da Silveira,Enio C de Oliveira,Karl Quint,Winfried Neuhuber,Axel Brehmer
International Journal of Colorectal Disease null
Olivia J Marola et al.
Cell death & disease, 11(9), 811-811 (2020-09-28)
Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs), the output neurons of the retina. Multiple lines of evidence show the endothelin (EDN, also known as ET) system is important in glaucomatous neurodegeneration. To date, the
Sumei Liu et al.
American journal of physiology. Gastrointestinal and liver physiology, 284(1), G154-G164 (2002-10-22)
Enteric neuroimmune interactions in gastrointestinal hypersensitivity responses involve antigen detection by mast cells, mast cell degranulation, release of chemical mediators, and modulatory actions of the mediators on the enteric nervous system (ENS). Electrophysiological methods were used to investigate electrical and
The role of neuronal connexins 36 and 45 in shaping spontaneous firing patterns in the developing retina.
Blankenship, AG; Hamby, AM; Firl, A; Vyas, S; Maxeiner, S; Willecke, K; Feller, MB
The Journal of Neuroscience null
Zhuonan Duan et al.
Neuroscience bulletin, 36(5), 493-505 (2020-01-21)
The caudal forelimb area (CFA) of the mouse cortex is essential in many forelimb movements, and diverse types of GABAergic interneuron in the CFA are distinct in the mediation of cortical inhibition in motor information processing. However, their long-range inputs
Krisztián Pajer et al.
Experimental neurology, 261, 180-189 (2014-06-08)
Following an injury to their axons close to the cell body, adult motoneurons generally die. This type of injury, typically caused by avulsion of the spinal ventral root, initiates the activation of astrocytes and microglial cells and the extracellular space
Short-Chain Fatty Acids Regulate the Enteric Neurons and Control Gastrointestinal Motility in Rats.
Soret R, Chevalier J, De Coppet P, Poupeau G, Derkinderen P, Segain JP, Neunlist M
Gastroenterology null
Sofia Esteves et al.
Molecular neurobiology, 56(5), 3626-3637 (2018-09-03)
Spinocerebellar ataxias are dominantly inherited neurodegenerative disorders with no disease-modifying treatment. We previously identified the selective serotonin reuptake inhibitor citalopram as a safe and effective drug to be repurposed for Machado-Joseph disease. Pre-symptomatic treatment of transgenic (CMVMJD135) mice strikingly ameliorated
Morphology, projection pattern, and neurochemical identity of Cajal's "centrifugal neurons": the cells of origin of the tectoventrogeniculate pathway in pigeon (Columba livia) and chicken (Gallus gallus).
Vega-Zuniga, T; Mpodozis, J; Karten, HJ; Marin, G; Hain, S; Luksch, H
The Journal of Comparative Neurology null
Clément Menuet et al.
eLife, 9 (2020-06-17)
Heart rate and blood pressure oscillate in phase with respiratory activity. A component of these oscillations is generated centrally, with respiratory neurons entraining the activity of pre-sympathetic and parasympathetic cardiovascular neurons. Using a combination of optogenetic inhibition and excitation in
Glucagon-like peptide-1 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in vitro.
Baldassano, S; Wang, GD; Mule, F; Wood, JD
American Journal of Physiology: Gastrointestinal and Liver Physiology null
Pamela Jarrett et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 45(2), 150-157 (2018-03-07)
Neuronal ceroid-lipofuscinoses are a heterogeneous group of inherited disorders in which abnormal lipopigments form lysosomal inclusion bodies in neurons. Kufs disease is rare, and clinical symptoms include seizures, progressive cognitive impairment, and myoclonus. Most cases of Kufs disease are autosomal
Aurélie Flaive et al.
Journal of neurophysiology, 123(6), 2326-2342 (2020-05-14)
Serotoninergic (5-HT) neurons are powerful modulators of spinal locomotor circuits. Most studies on 5-HT modulation focused on the effect of exogenous 5-HT and these studies provided key information about the cellular mechanisms involved. Less is known about the effects of
Katherine R Brimblecombe et al.
eNeuro, 5(5) (2018-11-09)
Striatal dopamine (DA) is a major player in action selection and reinforcement. DA release is under strong local control by striatal ACh acting at axonal nicotinic ACh receptors (nAChRs) on DA axons. Striatal nAChRs have been shown to control how
Nina A Dmitrieva et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 55(5), 461-476 (2006-12-26)
Cholinergic agents affect the light responses of many ganglion cells (GCs) in the mammalian retina by activating nicotinic acetylcholine receptors (nAChRs). Whereas retinal neurons that express beta2 subunit-containing nAChRs have been characterized in the rabbit retina, expression patterns of other
Fillan Grady et al.
Cerebral cortex (New York, N.Y. : 1991), 30(9), 4811-4833 (2020-05-10)
The parabrachial nucleus (PB) in the upper brain stem tegmentum includes several neuronal subpopulations with a wide variety of connections and functions. A subpopulation of PB neurons projects axons directly to the cerebral cortex, and limbic areas of the cerebral
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