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Qilu Fang et al.
Toxicology and applied pharmacology, 282(2), 129-138 (2014-12-03)
Inflammation plays a central role in the development and progression of diabetic nephropathy (DN). Researches on novel anti-inflammatory agents may offer new opportunities for the treatment of DN. We previously found a chalcone derivative L6H21 could inhibit LPS-induced cytokine release
Alan Yueh-Luen Lee et al.
Integrative cancer therapies, 14(5), 484-490 (2015-06-04)
Epithelial-mesenchymal transition (EMT) and invasion play a critical role in cancer progression and metastasis. We have shown that low E-cadherin and high Twist expression are significantly correlated with prognostic survival prediction in oral squamous cell carcinoma (OSCC). This study aimed
N Okudan et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(10), 844-848 (2013-05-08)
The aim of this study was to investigate the effects curcumin on inflammation and oxidative stress markers in the intestinal ischemia reperfusion (IIR) injury induced rats. Rats were divided into four groups: sham (S), intestinal IR (IIR), curcumin plus sham
Abigail R Esquivel et al.
The Journal of experimental biology, 223(Pt 22) (2020-10-11)
Oxidative stress, which occurs from an imbalance of reactive oxygen and nitrogen species (RONS) and both endogenous and exogenous antioxidants, promotes aging and underlies sex-specific differences in longevity and susceptibility to age-related neurodegeneration. Recent evidence suggests that curcumin, a yellow
Apei Jiang et al.
Journal of cellular biochemistry, 116(8), 1553-1562 (2015-02-05)
Ubiquitin activating enzyme E1-like (UBE1L) is the activating enzyme for ISG15ylation (ISG15, interferon stimulated gene 15). UBE1L is thought to be a candidate tumor suppressor gene and has positive activity against stress responses such as viral infections. Both type I
Gopa Dhar et al.
Biochemistry, 54(4), 1132-1143 (2015-01-08)
Curcumin, derived from rhizomes of the Curcuma longa plant, is known to possess a wide range of medicinal properties. We have examined the interaction of curcumin with actin and determined their binding and thermodynamic parameters using isothermal titration calorimetry. Curcumin
Hannelore Rücker et al.
Organic & biomolecular chemistry, 13(10), 3040-3047 (2015-01-27)
Inflammatory signaling pathways orchestrate the cellular response to infection and injury. These pathways are known to be modulated by compounds that alkylate cysteinyl thiols. One class of phytochemicals with strong thiol alkylating activity is the chalcones. In this study we
Rashmi Sareen et al.
Current drug targets, 14(10), 1210-1218 (2013-06-19)
Curcumin, a natural polyphenolic compound present in turmeric, exhibited multiple pharmacological activities. Extensive studies in last two decade suggested that curcumin possesses anti-inflammatory, anticancer, antiviral, anti-amyloid, antiarthritic and antioxidant properties. The mechanism for these effects involves modulation of several signaling
Ahmed H Matloob et al.
International journal of pharmaceutics, 476(1-2), 108-115 (2014-10-01)
Curcumin (CURC) was incorporated in liposomes as free drug or after formation of hydropropyl-β- or hydroxypropyl-γ-cyclodextrin (HPβCD or HPγCD) complexes prepared by coprecipitation and characterized by X-ray diffractometry. Liposomes encapsulating CURC as free drug or CD-complexes (hybrid formulations) were prepared
Nikhil Baban Ghate et al.
PloS one, 10(5), e0128221-e0128221 (2015-05-27)
Free iron typically leads to the formation of excess free radicals, and additional iron deposition in the liver contributes to the oxidative pathologic processes of liver disease. Many pharmacological properties of the insectivorous plant Drosera burmannii Vahl. have been reported
Paula Aranaz et al.
Pharmaceuticals (Basel, Switzerland), 13(11) (2020-11-05)
Supplementation with bioactive compounds capable of regulating energy homeostasis is a promising strategy to manage obesity. Here, we have screened the ability of different phenolic compounds (myricetin, kaempferol, naringin, hesperidin, apigenin, luteolin, resveratrol, curcumin, and epicatechin) and phenolic acids (p-coumaric
Katiúscia Vieira Jardim et al.
Materials science & engineering. C, Materials for biological applications, 56, 294-304 (2015-08-08)
In this study, chitosan (CTS)/chondroitin sulfate (CS) nanoparticles, both pure and curcumin-loaded, were synthesized by ionic gelation. This method is simple and efficient for obtaining nanoparticles with a low polydispersity index (0.151±0.03 to 0.563±0.07) and hydrodynamic diameter in the range
Alfeu Zanotto-Filho et al.
Cancer letters, 358(2), 220-231 (2014-12-30)
Glioblastoma is a devastating primary brain tumor resistant to conventional therapies. In this study, we tested the efficacy of combining temozolomide with curcumin, a phytochemical known to inhibit glioblastoma growth, and investigated the mechanisms involved. The data showed that synergy
Krupa Shah et al.
Anti-cancer agents in medicinal chemistry, 16(1), 128-135 (2015-08-19)
The aim of the study was to find a role of Curcumin from natural source to overcome drug resistance as well as to reduce cytotoxicity profile of the drug in Acute Myeloid Leukemia patients. Primary leukemic cells were obtained from
Samina Akhter et al.
BioMed research international, 2015, 356729-356729 (2015-07-30)
This research investigated the protective role of Leea macrophylla extract on CCl4-induced acute liver injury in rats. Different fractions of Leea macrophylla (Roxb.) crude extract were subjected to analysis for antioxidative effects. Rats were randomly divided into four groups as
Li-na Sun et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(8), 1079-1088 (2014-12-03)
Epithelial-mesenchymal transition (EMT) is recognized to play a key role in diabetic nephropathy (DN). Curcumin, the main active component of turmeric extracted from the roots of the Curcuma longa plant, has been reported for its anti-fibrotic effects in kidney fibrosis. The
Xinna Wang et al.
Ultrasonics, 54(8), 2109-2114 (2014-07-26)
Methicillin-Resistant Staphylococcus aureus (MRSA) is an important cause of difficult-to-treat infections. The present study aims to investigate sonodynamic inactivation of MRSA in planktonic condition using curcumin under ultrasound sonication. Dark toxicity of curcumin to MRSA was investigated to choose the
Soumyananda Chakraborti et al.
Biochemistry, 52(42), 7449-7460 (2013-09-26)
Curcumin has shown promising therapeutic utilities for many diseases, including cancer; however, its clinical application is severely limited because of its poor stability under physiological conditions. Here we find that curcumin also loses its activity instantaneously in a reducing environment.
Masahito Takikawa et al.
Biochemical and biophysical research communications, 435(2), 165-170 (2013-05-11)
Glucagon-like peptide-1 (GLP-1) is a hormone secreted from enteroendocrine L-cells. Enhancing GLP-1 action is an important target for prevention and treatment of type 2 diabetes. Several approaches (GLP-1 analogs, dipeptidyl peptidase IV inhibitors) are being used to develop therapeutic agents
Partha Pratim Roy et al.
Bioorganic chemistry, 56, 1-7 (2014-06-03)
The objective of the present work was tantamount to explain the antiperoxidative potential and structural requirements of twenty-eight structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation. Both experimental and computational approaches were taken to the work. The experiments were
Kun-mu Zheng et al.
Acta pharmacologica Sinica, 36(5), 544-552 (2015-04-22)
Appoptosin (SLC25A38) is a pro-apoptotic protein, which is upregulated in Alzheimer's disease (AD) brains and plays an important role in promoting the pathological progress of AD. The aim of this study was to investigate the effects of curcumin from the
Yueliu Sun et al.
Biological & pharmaceutical bulletin, 38(8), 1134-1141 (2015-08-04)
Endothelial senescence has been proposed to be involved in endothelial dysfunction and atherogenesis. Curcumin, a natural phenol, possesses antioxidant and anti-inflammatory properties. However, the effect of curcumin on endothelial senescence is unclear. This study explores the effect of curcumin on
Prabha Arya et al.
ACS chemical neuroscience, 5(10), 982-992 (2014-08-15)
The pathogenesis of protein misfolding diseases is attributed to the cytotoxicity caused by amyloidogenic prefibrillar aggregates, rather than mature fibrils. The presence of one or more amyloidogenic stretches in different proteins has been proven critical for initiating fibril formation. In
S K Jain et al.
Indian journal of pharmaceutical sciences, 76(5), 415-422 (2014-11-27)
Curcumin-diclofenac conjugate as been synthesized by esterification of phenolic group of curcumin with the acid moiety of diclofenac, and characterized by mass spectrometry, NMR, FTIR, DSC, thermogravimetric analysis and X-ray diffraction analysis. The relative solubility of curcumin-diclofenac conjugate, curcumin and
Tomoaki Haraguchi et al.
Journal of agricultural and food chemistry, 62(24), 5589-5594 (2014-05-27)
This study demonstrated that 0.5% dietary rutin, ellagic acid, or curcumin markedly increased cecal succinate levels in rats fed a high-fat diet, whereas catechin, caffeic acid, and quercetin did not. Other organic acids were modestly or hardly affected by polyphenols.
Panga Jaipal Reddy et al.
PloS one, 10(4), e0120620-e0120620 (2015-04-16)
Curcumin is a natural dietary compound with antimicrobial activity against various gram positive and negative bacteria. This study aims to investigate the proteome level alterations in Bacillus subtilis due to curcumin treatment and identification of its molecular/cellular targets to understand
Kyoung-Woon Kim et al.
The American journal of pathology, 185(11), 3011-3024 (2015-09-13)
This study determined the effect of type 17 helper T-cell (Th17) cytokines on osteoclastogenesis in rheumatoid arthritis (RA). The expression of IL-17 and receptor activator of NF-κB ligand (RANKL) was determined in synovial tissue, fibroblast-like synoviocytes (FLSs), and synovial fluids
Antonelle Pardo et al.
Journal of chromatography. A, 1364, 128-139 (2014-09-10)
Molecularly imprinted polymers (MIPs) based on quercetin and synthesized by either bulk, precipitation or suspension polymerization were characterized in terms of size and shape by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). After a study of rebinding protocols
Yoshikane Yamauchi et al.
Phytotherapy research : PTR, 28(5), 728-735 (2013-08-15)
Resistance to erlotinib in lung cancer cases includes T790M mutant epidermal growth factor receptor and c-Met gene amplification, but other unknown mechanisms account for about 30% of the resistance. Activation of the nuclear factor kappa B (NFkappaB)-related pathways in association
Venus Singh Mithu et al.
The Journal of biological chemistry, 289(16), 11122-11131 (2014-03-07)
Amyloid β (Aβ) fibrillar deposits in the brain are a hallmark of Alzheimer disease (AD). Curcumin, a common ingredient of Asian spices, is known to disrupt Aβ fibril formation and to reduce AD pathology in mouse models. Understanding the structural
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