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Fang-Yuan Chen et al.
Biochemical and biophysical research communications, 467(4), 872-878 (2015-10-17)
Lipoprotein cholesterol metabolism dysfunction in the arterial wall is a major contributor to atherosclerosis, and excessive lipid intake and failed cholesterol homeostasis may accelerate the atherogenic process. Curcumin exerts multiple effects by alleviating inflammation, hyperlipidemia, and atherosclerosis; however, its role...
Xunsi Qin et al.
PloS one, 10(6), e0127551-e0127551 (2015-06-02)
Oxidative stress (OS), as a signal of aberrant intracellular mechanisms, plays key roles in maintaining homeostasis for organisms. The occurrence of OS due to the disorder of normal cellular redox balance indicates the overproduction of reactive oxygen species (ROS) and/or...
Chen Xie et al.
Journal of cellular physiology, 230(8), 1906-1915 (2014-12-30)
Benign prostatic hyperplasia (BPH) is a hyper-proliferative disease of the aging prostate; however, the exact mechanism underlying the development of BPH remains incompletely understood. The present study investigated the possible involvement of the cystic fibrosis transmembrane conductance regulator (CFTR), which...
Tina L Samuels et al.
The Annals of otology, rhinology, and laryngology, 122(10), 632-641 (2013-12-04)
Laryngopharyngeal reflux (LPR) is associated with inflammatory and neoplastic airway diseases. Gastric pepsin internalized by airway epithelial cells during reflux contributes to oxidative stress, inflammation, and carcinogenesis. Several plant extracts and compounds inhibit digestive enzymes and inflammatory or neoplastic changes...
Mamatha Garige et al.
Biochemical and biophysical research communications, 467(2), 275-281 (2015-10-10)
The molecular basis for nutraceutical properties of the polyphenol curcumin (Curcuma longa, Turmeric) is complex, affecting multiple factors that regulate cell signaling and homeostasis. Here, we report the effect of curcumin on cellular and developmental mechanisms in the eukaryotic model...
[The mechanism progress of anti-fibrosis by curcumin].
Hui-Chun Wu et al.
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 33(1), 135-137 (2013-04-20)
Zhi-Dong Lv et al.
International journal of clinical and experimental pathology, 7(6), 2818-2824 (2014-07-18)
Curcumin has shown therapeutic and/or adjuvant therapeutic effects on the treatment of some patients with breast cancer. However, its mechanisms of action are largely unknown. This study was designed to investigate its antitumor effect and underlying mechanisms in human breast...
Z B Song et al.
Cell death & disease, 6, e1703-e1703 (2015-03-27)
The high mortality in breast cancer is often associated with metastatic progression in patients. Previously we have demonstrated that testes-specific protease 50 (TSP50), an oncogene overexpressed in breast cancer samples, could promote cell proliferation and tumorigenesis. However, whether TSP50 also...
Jinfeng Zhang et al.
Nanoscale, 7(32), 13503-13510 (2015-07-23)
The use of different nanocarriers for delivering hydrophobic pharmaceutical agents to tumor sites has garnered major attention. Despite the merits of these nanocarriers, further studies are needed to improve their drug loading capacities (which are typically <10%) and reduce their...
Jinling Wang et al.
Colloids and surfaces. B, Biointerfaces, 133, 108-119 (2015-06-22)
Curcumin-loaded self-assembled polymeric micelles (Cur-PMs) were designed to increase oral bioavailability of curcumin and investigate the oral absorption mechanism in vitro and in vivo. The Cur-PMs were spherical nano-size particles 17.82±0.33nm in size, with a drug loading of 3.52±0.18%, and...
Ziao Fu et al.
Biochemistry, 53(50), 7893-7903 (2014-11-26)
Aβ42 peptides associate into soluble oligomers and protofibrils in the process of forming the amyloid fibrils associated with Alzheimer's disease. The oligomers have been reported to be more toxic to neurons than fibrils, and have been targeted by a wide...
Farid A Badria et al.
PloS one, 10(7), e0134156-e0134156 (2015-08-01)
Iron overload is now recognized as a health problem in industrialized countries, as excessive iron is highly toxic for liver and spleen. The potential use of curcumin as an iron chelator has not been clearly identified experimentally in iron overload...
Panida Chanapiwat et al.
Animal science journal = Nihon chikusan Gakkaiho, 86(9), 863-868 (2015-06-03)
The aim of this study was to determine the optimal concentration of curcumin needed for cryopreservation of boar semen. Semen samples (n = 9) were collected from nine Duroc boars which having proven fertility were used for routine artificial insemination. Semen samples...
Praveen Nair et al.
Molecular and cellular biochemistry, 400(1-2), 51-56 (2014-11-02)
The aim of the present study was to assess the cumulative effects of curcumin and quercetin in inducing apoptosis during benzo(a)pyrene (BP) (100 mg/Kg body weight)-induced lung carcinogenesis in mice. BP treatment resulted in a significant increase in the protein...
Katarzyna Głombik et al.
Pharmacological reports : PR, 66(5), 782-787 (2014-08-26)
Curcumin is a phytochemical derived from rhizome of turmeric Curcuma longa, present in the curry spice. Recently, it has attracted the attention of researchers and clinicians as an anti-inflammatory and anti-oxidant agent with a potential use in therapy of many...
Yeter Topcu-Tarladacalisir et al.
Journal of medicinal food, 16(4), 296-305 (2013-04-10)
The present study evaluated the effects of curcumin on epithelial cell apoptosis, the immunoreactivity of the phospho-c-Jun N-terminal kinase (JNK) and phospho-p38 mitogen-activated protein kinases (MAPKs) in inflamed colon mucosa, and oxidative stress in a rat model of ulcerative colitis...
Zhongping Fu et al.
Oncotarget, 6(23), 19469-19482 (2015-08-09)
Curcumin, a natural polyphenol compound from the perennial herb Curcuma longa, has been proved to be beneficial for tumor-bearing animals through inhibiting tumor neovasculature formation, but the underlying mechanisms are unclear. Here, we aim to test whether curcumin affects VEGF-VEGFR2...
Nguyen Tuan Hiep et al.
Phytochemistry, 111, 141-148 (2014-12-10)
Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D...
Li M Y et al.
Biochemical and biophysical research communications, 446(2), 626-632 (2014-03-19)
Recently, synthetic curcumin analogs are reported as potential active compounds against Mycobacterium tuberculosis (MTB). During the process of MTB infection, macrophages show increased apoptosis. The candidate virulence factors such as 19-kDa lipoprotein secreted by the MTB (P19) strongly influences macrophages...
Zhen Wang et al.
Behavioural brain research, 274, 282-290 (2014-08-19)
Current evidence supports that inflammation and increased cytokine levels are associated with depression-like symptoms and neuropsychological disturbances in humans. Curcumin has anti-inflammatory, antioxidant and anti-depressant-like properties. Here, we examined the effects of curcumin on lipopolysaccharide (LPS)-induced depressive-like behavior and inflammation...
Massimiliano Magro et al.
Journal of agricultural and food chemistry, 63(3), 912-920 (2015-01-15)
Naked maghemite nanoparticles, namely, surface active maghemite nanoparticles (SAMNs), characterized by a diameter of about 10 nm, possessing peculiar colloidal stability, surface chemistry, and superparamagnetism, present fundamental requisites for the development of effective magnetic purification processes for biomolecules in complex...
In-Soo Yoon et al.
International journal of pharmaceutics, 488(1-2), 70-77 (2015-04-23)
Poly(D,L-lactic acid)-glycerol (PDLLA-G)-based nanoparticles (NPs) were fabricated for the intravenous delivery of curcumin (CUR). NPs with a mean diameter of approximately 200 nm, a narrow size distribution, and capable of efficient drug encapsulation were prepared using an emulsification-solvent evaporation method....
L T Gressler et al.
Parasitology, 142(3), 439-448 (2014-08-20)
This study aimed to evaluate in vitro and in vivo trypanocidal activity of free and nanoencapsulated curcumin against Trypanosoma evansi. In vitro efficacy of free curcumin (CURC) and curcumin-loaded in lipid-core nanocapsules (C-LNCs) was evaluated to verify their lethal effect...
Chuan-Chuan Lin et al.
Food chemistry, 154, 282-290 (2014-02-13)
The choice of surfactants and cosurfactants for preparation of oral formulation in microemulsions is limited. In this report, a curcumin-encapsulated phospholipids-based microemulsion (ME) using food-grade ingredients soybean oil and soybean lecithin to replace ethyl oleate and purified lecithin from our...
Arul Prakash Francis et al.
Journal of nanoscience and nanotechnology, 14(7), 4865-4873 (2014-04-25)
We have optimized a protocol for the preparation of bisdemethoxy curcumin analog nanoparticles (BDMCA-NP) by the solvent assisted process. The structural similarities between bulk and nano BDMCA were determined by Co-TLC, NMR and F-TIR. This shows that our synthesis protocol...
Carolina Veronez Garbúggio Sanches et al.
Biofouling, 35(3), 340-349 (2019-05-09)
This study evaluated the effect of antimicrobial photodynamic therapy (aPDT) on S. mutans using diacetylcurcumin (DAC) and verified DAC toxicity. In vitro, S. mutans biofilms were exposed to curcumin (CUR) and DAC and were light-irradiated. Biofilms were collected, plated and...
Letícia Mazzarino et al.
Journal of biomedical nanotechnology, 10(5), 787-794 (2014-04-17)
Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D) was used to investigate the mucoadhesive properties of nanoparticles decorated with low, medium and high molar mass chitosan (CS). Uncoated and chitosan-coated polycaprolactone (PCL) nanoparticles loaded with curcumin were prepared by nanoprecipitation method...
Ke Wang et al.
Anti-cancer drugs, 26(1), 15-24 (2014-09-18)
Curcumin, the major pigment of the dietary spice turmeric, has the potential for chemoprevention by promotion of apoptosis. Here, we investigated the molecular mechanisms of curcumin in glycolytic inhibition and apoptotic induction in human colorectal cancer HCT116 and HT29 cells....
Qiang Wan et al.
Bio-medical materials and engineering, 27(6), 577-587 (2017-02-25)
Curcumin possesses significant anti-atherosclerosis properties. Lipocalin-2 (LCN2) is already known as one of the most promising biomarkers of atherosclerosis. However, research on the effect of curcumin on regulating LCN2 expression in atherogenesis is very limited. The aim of the study...
Barira Islam et al.
Drug design, development and therapy, 9, 4943-4951 (2015-09-12)
Statins are hypolipidemic drugs that are effective in the treatment of hypercholesterolemia by attenuating cholesterol synthesis in the liver via competitive inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Recently, dietary changes associated with drug therapy have garnered attention as novel drugs...
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