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Nathalie Bock et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 366-377 (2014-03-25)
The fabrication of tailored microparticles for delivery of therapeutics is a challenge relying upon a complex interplay between processing parameters and materials properties. The emerging use of electrospraying allows better tailoring of particle morphologies and sizes than current techniques, critical
Rosa Ana Pérez et al.
Analytical and bioanalytical chemistry, 407(7), 1913-1924 (2015-02-04)
Two magnetic solid-phase extraction methods (mSPE) were developed and compared for the extraction and preconcentration of polychlorinated biphenyls (PCBs) from water and soil leachates. Analyses were carried out by gas chromatography coupled to triple quadrupole mass spectrometry. The mSPE extraction
Matthew K Gelber et al.
Lab on a chip, 15(7), 1736-1741 (2015-02-12)
Here we demonstrate a method for creating multilayer or 3D microfluidics by casting a curable resin around a water-soluble, freestanding sacrificial mold. We use a purpose-built 3D printer to pattern self-supporting filaments of the sugar alcohol isomalt, which we then
Masoud Samet et al.
Organic & biomolecular chemistry, 13(7), 2170-2176 (2014-12-24)
Different strategies are employed in designing strong and selective anion receptors but stereoelectronic effects have been largely ignored. In this work, the stereo configuration of a non-interacting ether is found to have a large impact of more than two orders
S Rudnick-Glick et al.
Journal of nanobiotechnology, 13, 80-80 (2015-11-19)
Bisphosphonate (BP) compounds are widely used in the treatment of bone disorders. This group of drugs with a high affinity to Ca(+2) ions is rapidly attracted to bone mineral, especially in areas of high resorption. We have engineered unique biodegradable
Marco Parolini et al.
Journal of hazardous materials, 285, 1-10 (2014-12-03)
Synthetic musk compounds (SMCs) are extensively used as fragrances in several personal care products and have been recognized as emerging aquatic pollutants. Among SMCs, galaxolide (HHCB) and tonalide (AHTN) are extensively used and have been measured in aquatic ecosystems worldwide.
Urve Paaver et al.
International journal of pharmaceutics, 479(1), 252-260 (2015-01-01)
Electrospinning was introduced as a novel technique for preparing controlled-release (CR) amorphous solid dispersions (SD) and polymeric nanofibers of a poorly water-soluble drug. Piroxicam (PRX) was used as a low-dose poorly-soluble drug and hydroxypropyl methylcellulose (HPMC) as an amorphous-state stabilising
Shannon L Haughney et al.
Nanoscale, 6(22), 13770-13778 (2014-10-07)
Acute respiratory infections represent a significant portion of global morbidity and mortality annually. There is a critical need for efficacious vaccines against respiratory pathogens. To vaccinate against respiratory disease, pulmonary delivery is an attractive route because it mimics the route
Kelly M Mabry et al.
Biomaterials, 74, 31-41 (2015-10-05)
Valvular interstitial cells (VICs) actively maintain and repair heart valve tissue; however, persistent activation of VICs to a myofibroblast phenotype can lead to aortic stenosis. To better understand and quantify how microenvironmental cues influence VIC phenotype and myofibroblast activation, we
Meredith C Schuman et al.
eLife, 4 (2015-04-16)
Plants are at the trophic base of terrestrial ecosystems, and the diversity of plant species in an ecosystem is a principle determinant of community structure. This may arise from diverse functional traits among species. In fact, genetic diversity within species
Yunxia Jiang et al.
International journal of pharmaceutics, 475(1-2), 475-484 (2014-09-16)
The purpose of this study was to develop a sustained-release drug delivery system based on the injectable PLGA microspheres loaded with andrographolide. The andrographolide loaded PLGA microspheres were prepared by emulsion solvent evaporation method with optimization of formulation using response
Naghmeh Soltani et al.
The Science of the total environment, 505, 712-723 (2014-12-03)
This study investigates trace elements and PAHs content in road dust of Isfahan metropolis, central Iran. The mean concentrations of As, Cd, Cu, Ni, Pb, Sb and Zn are 22.15, 2.14, 182.26, 66.63, 393.33, 6.95 and 707.19 mg kg(-1), respectively.
Jérôme Cotton et al.
Journal of agricultural and food chemistry, 62(46), 11335-11345 (2014-10-31)
Analytical methods for food control are mainly focused on restricted lists of well-known contaminants. This paper shows that liquid chromatography-high-resolution mass spectrometry (LC/ESI-HRMS) associated with the data mining tools developed for metabolomics can address this issue by enabling (i) targeted
Daishun Ling et al.
ACS nano, 8(8), 8027-8039 (2014-08-06)
Hepatocellular carcinoma (HCC) has one of the worst prognoses for survival as it is poorly responsive to both conventional chemotherapy and mechanism-directed therapy. This results from a lack of therapeutic concentration in the tumor tissue coupled with the highly toxic
Instrument and technique for the in vitro screening of platelet activation from whole blood samples.
Martin Y, et al.
The Review of Scientific Instruments, 78(5), 054302-054302 (2007)
Akiyoshi Hirata et al.
Journal of the American Chemical Society, 136(32), 11546-11554 (2014-07-19)
A polyamide containing N-methylpyrrole (Py) and N-methylimidazole (Im), designated PIPA, binds with high affinity and specificity to specific nucleotide sequences in the minor groove of double-helical DNA. Based on a recent report of the synthesis of PIPA for telomere visualization
D Pasupuleti et al.
Journal of chromatography. A, 1421, 162-170 (2015-10-03)
Alkyl esters of fatty acids (FAAEs) with carbon numbers from 8 to 20 formed protonated monomers and proton bound dimers through atmospheric pressure chemical ionization reactions and these gas ions were characterized for their field dependent mobility coefficients using differential
Markus W Tackenberg et al.
International journal of pharmaceutics, 478(2), 597-605 (2014-12-17)
Essential oils and other liquid active pharmaceutical ingredients (APIs) are frequently microencapsulated to improve shelf life, handling, and for tailoring release. A glassy solid solution (GSS), a single-phase system, where the excipient is plasticized by the API, could be an
Nayara Cristina Perez de Albuquerque et al.
Journal of pharmaceutical and biomedical analysis, 109, 192-201 (2015-03-18)
Zopiclone (ZO) is a chiral drug that undergoes extensive metabolism to N-desmethylzopiclone (N-Des-ZO) and zopiclone-N-oxide (N-Ox-ZO). Pharmacological studies have shown (S)-N-Des-ZO metabolite presents anxiolytic activity and a patent for this metabolite was requested for anxiety treatment and related disorders. In
Robert J Cannon et al.
Journal of agricultural and food chemistry, 63(7), 1915-1931 (2015-02-03)
Lemons (Citrus limon) are a desirable citrus fruit grown and used globally in a wide range of applications. The main constituents of this sour-tasting fruit have been well quantitated and characterized. However, additional research is still necessary to better understand
Sridhar Veeraraghavan et al.
Journal of pharmaceutical and biomedical analysis, 107, 151-158 (2015-01-17)
Efficacy assessments using a combination of ibrutinib and lenalidomide necessitate the development of an analytical method for determination of both drugs in plasma with precision. A high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination
Romina Vitale et al.
ChemMedChem, 9(2), 323-336 (2014-01-10)
N-Acylethanolamine acid amidase (NAAA) is a cysteine amidase that preferentially hydrolyzes saturated or monounsaturated fatty acid ethanolamides (FAEs), such as palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), which are endogenous agonists of nuclear peroxisome proliferator-activated receptor-α (PPAR-α). Compounds that feature an α-amino-β-lactone
Hui Peng et al.
Environmental science & technology, 49(5), 2999-3006 (2015-01-27)
Ultra-High Resolution LC/mass spectrometry (LC-UHRMS; Thermo Fisher Q-Exactive) was used to identify two novel isomers of hydroxylated bis(2-ethylhexyl)-tetrabromophthalate (OH-TBPH) which were unexpectedly observed in a commercial standard of TBPH. By combining ultra-high resolution (UHR) mass spectra (MS(1)), mass errors to
Shohei Takai et al.
Journal of applied toxicology : JAT, 36(1), 35-47 (2015-04-23)
Drug-induced liver injury (DILI) is the most frequent cause of post-marketing warnings and withdrawals. Amiodarone (AMD), an antiarrhythmic, presents a risk of liver injury in humans, and its metabolites, formed by cytochrome P450 3A4, are likely more toxic to hepatocytes
Daniel T Bowers et al.
ACS nano, 8(12), 12080-12091 (2014-11-27)
Oxygenation in tissue scaffolds continues to be a limiting factor in regenerative medicine despite efforts to induce neovascularization or to use oxygen-generating materials. Unfortunately, many established methods to measure oxygen concentration, such as using electrodes, require mechanical disturbance of the
Kai Yu et al.
Environmental technology, 36(5-8), 1008-1015 (2014-10-18)
The polycyclic aromatic hydrocarbons (PAHs) in crumb tyre rubber were firstly degraded under UV irradiation in the presence of rutile TiO2 and hydrogen peroxide. The effects of light intensity, catalyst amount, oxidant amount, initial pH value, co-solvent content, and reaction
David G Belair et al.
Biomacromolecules, 15(6), 2038-2048 (2014-04-30)
Vascular endothelial growth factor (VEGF) activity is highly regulated via sequestering within the ECM and cell-demanded proteolysis to release the sequestered VEGF. Numerous studies have demonstrated that VEGF activity mediates cellular events leading to angiogenesis and capillary formation in vivo.
Eveline Dischkaln Stolz et al.
The Journal of pharmacy and pharmacology, 66(12), 1774-1785 (2014-08-15)
Investigate the involvement of monoaminergic and glutamatergic systems on the antinociceptive and ataxic effects of uliginosin B, which we have already demonstrated to be a promising molecular scaffold to develop new analgesic drugs. Uliginosin B was obtained from hexane extract
Wojciech Prus et al.
The Science of the total environment, 518-519, 266-279 (2015-03-17)
The organic contamination of Antarctic soils and terrestrial sediments from nearby of five polar scientific stations on King George Island (Antarctica) was investigated. Gas chromatography-mass spectrometry (GC-MS) was applied to find composition of dichloromethane extracts of soil and terrestrial sediments.
Yu Zhang et al.
Environmental science and pollution research international, 21(16), 9468-9476 (2013-08-15)
Nonylphenol ethoxylates (NPEOs) with low ethoxylation degree (NPav₂EO; containing two ethoxy units on average) and estrogenic properties are the intermediate products of nonionic surfactant NPEOs. To better understand the environmental fate of low-ethoxylated NPEOs, phylogenetically diverse low-ethoxylated NPEO-degrading bacteria were
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