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Hua Chen et al.
Basic & clinical pharmacology & toxicology, 127(2), 152-159 (2020-04-16)
We investigated whether sex differences exist in cyclooxygenase-dependent effects on membrane potential and relaxation in mice mesenteric resistance arteries. Mesenteric small arteries of 9- to 12-week-old, male and female, wild-type mice, db/+ mice and diabetic db/db mice were mounted in
Divyashree Ravishankar et al.
European journal of pharmacology, 862, 172627-172627 (2019-08-29)
Isorhapontigenin is a polyphenolic compound found in Chinese herbs and grapes. It is a methoxylated analogue of a stilbenoid, resveratrol, which is well-known for its various beneficial effects including anti-platelet activity. Isorhapontigenin possesses greater oral bioavailability than resveratrol and has
Chia-Chia Chao et al.
Clinical science (London, England : 1979), 133(5), 709-722 (2019-02-28)
The epithelial-mesenchymal transition (EMT) phenotype, whereby mature epithelial cells undergo phenotype transition and differentiate into motile, invasive cells, has been indicated in tumor metastasis. The melatonin hormone secreted by the pineal gland has an antioxidant effect and protects cells against
Elani F Wiest et al.
Toxicological sciences : an official journal of the Society of Toxicology, 156(1), 300-310 (2017-01-25)
In cigarette smokers endothelial dysfunction, measured by flow-mediated dilation (FMD), precedes cardiovascular disease (CVD) and can be improved by supplementation with n - 3 polyunsaturated fatty acids (PUFAs). We developed a mouse model of cigarette smoke (CS)-induced endothelial dysfunction that
C E Hayward et al.
Placenta, 34(3), 281-287 (2013-01-31)
To characterise Chorionic Plate Artery (CPA) function in maternal obesity, and investigate whether leptin exposure reproduces the obese CPA phenotype in normal-BMI women. CPA responses to the thromboxane-A(2) mimetic U46619 (pre/post leptin incubation), to the nitric oxide donor sodium nitroprusside
Jens van de Wouw et al.
Basic research in cardiology, 115(2), 21-21 (2020-02-27)
Comorbidities of ischemic heart disease, including diabetes mellitus (DM), hypercholesterolemia (HC) and chronic kidney disease (CKD), are associated with coronary microvascular dysfunction (CMD). Increasing evidence suggests that CMD may contribute to myocardial 'Ischemia and No Obstructive Coronary Artery disease' (INOCA).
Ludovic Waeckel et al.
Pflugers Archiv : European journal of physiology, 467(9), 1945-1963 (2014-11-12)
Angiotensin-II and oxidative stress are involved in the genesis of aortic aneurysms, a phenomenon exacerbated by endothelial nitric oxide synthase (eNOS) deletion or uncoupling. The purpose of this work was to study the endothelial function in wild-type C57BL/6 (BL) and
Li Zeng et al.
Molecular medicine reports, 15(5), 2853-2858 (2017-04-28)
Osteoarthritis (OA) is the most common type of arthritis and is a leading cause of disability worldwide, resulting in pain, reduced quality of life and socioeconomic burden. Current therapies for OA focus on mitigating the symptoms of advanced disease, but
Z Huang et al.
Thrombosis and haemostasis, 112(1), 142-150 (2014-03-19)
ATP released by activated platelets can serve as a positive feedback machinery to amplify platelet responses by activating P2X1 receptors. It has, however, not been defined how P2X1 activities influence thromboxane A2 (TXA2)-stimulated platelet functional responses. Our aim was to
Tzu-Yin Lee et al.
Scientific reports, 7, 40002-40002 (2017-01-06)
Honokiol, derived from Magnolia officinalis, has various pharmacological properties. Platelet activation plays a critical role in cardiovascular diseases. Honokiol has been reported to inhibit collagen-stimulated rabbit platelet aggregation. However, detailed further studies on the characteristics and functional activity of honokiol
Sidse Kringelholt et al.
Acta ophthalmologica, 91(6), 498-504 (2012-08-07)
Prostaglandin analogues are used to reduce the intraocular pressure (IOP) in glaucoma, but also affect the tone of the arteries supplying the ciliary body. Previously, the effect of prostaglandins has been studied on the extraocular ciliary arteries, whereas the effect
Lenka Applová et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 35, 11-17 (2017-10-11)
One reason for the lower incidence of cardiovascular diseases in Asian countries may be the high intake of isoflavonoids and their antiplatelet effects may be an important factor. To date, there is limited comparison of a range of isoflavonoids and
Willem Abma et al.
Prostaglandins & other lipid mediators, 149, 106428-106428 (2020-02-20)
Lipoxin A4 (LXA4) is considered a specialised pro-resolving mediator that decreases inflammation: however, pro-inflammatory effects have been described in the airways. Here, we investigated whether LXA4 could influence airway hyperreactivity induced in mouse trachea by house dust mite extract (HDM)
D Nakladal et al.
Scientific reports, 9(1), 13-13 (2019-01-11)
SUL-compounds are protectants from cold-induced ischemia and mitochondrial dysfunction. We discovered that adding SUL-121 to renal grafts during warm machine reperfusion elicits a rapid improvement in perfusion parameters. Therefore, we investigate the molecular mechanisms of action in porcine intrarenal arteries
Sajal Chakraborti et al.
Archives of biochemistry and biophysics, 540(1-2), 133-144 (2013-11-05)
Treatment of bovine pulmonary artery smooth muscle cells (BPASMCs) with U46619 attenuated isoproterenol caused stimulation of adenyl cyclase activity and cAMP production. Pretreatment with SQ29548 (Tp receptor antagonist), apocynin (NADPH oxidase inhibitor) and Go6976 (PKC-α inhibitor) eliminated U46619 caused attenuation
Emanuella Feitosa de Carvalho et al.
Naunyn-Schmiedeberg's archives of pharmacology, 393(1), 43-55 (2019-08-20)
Neryl butyrate is a constituent of volatile oils obtained from aromatic plants. Aliphatic organic compound analogues chemically close to neryl butyrate possess vasodilator properties in rat aorta. To evaluate whether neryl butyrate has relaxing properties, this study tested its effects
Abnormal neurovascular coupling as a cause of excess cerebral vasodilation in familial migraine.
Staehr, et al.
Cardiovascular Research, 116, 2009-2020 (2020)
Mitsuya Shiraishi et al.
Life sciences, 92(14-16), 838-844 (2013-03-19)
Hypersensitivity of platelets due to increased platelet cholesterol levels has been reported in hypercholesterolemia. However, the signaling pathways linking increased platelet reactivity and cholesterol contents are not fully understood. This study aims to determine the direct effect of cholesterol enrichment
Kira Vanessa Blankenbach et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(7), 158704-158704 (2020-04-04)
Sphingosine kinases (SphK) catalyse the formation of sphingosine-1-phosphate (S1P) and play important roles in the cardiovascular, nervous and immune systems. We have shown before that Gq-coupled receptors induce a rapid and long-lasting translocation of SphK1 to the plasma membrane and
Siu-Lung Chan et al.
Acta physiologica (Oxford, England), 225(2), e13181-e13181 (2018-08-29)
Adaptive responses of brain parenchymal arterioles (PAs), a target for cerebral small vessel disease, to chronic cerebral hypoperfusion are largely unknown. Previous evidence suggested that transient receptor potential vanilloid 4 channels may be involved in the regulation of cerebrovascular tone.
Aglaia Maria Klose et al.
International journal of molecular sciences, 21(9) (2020-05-07)
Phospholipase (PL)D1 is crucial for integrin αIIbβ3 activation of platelets in arterial thrombosis and TNF-α-mediated inflammation and TGF-β-mediated collagen scar formation after myocardial infarction (MI) in mice. Enzymatic activity of PLD is not responsible for PLD-mediated TNF-α signaling and myocardial
Ivan Budnik et al.
Platelets, 29(3), 265-269 (2017-04-14)
Mechanisms of platelet activation are triggered by thrombin, adenosine diphosphate (ADP), epinephrine, thromboxane A2, and other soluble agonists which induce signaling via heterotrimeric Gαq, Gαi, and Gα12/13 proteins. We have undertaken a study addressing the contribution of these G proteins
Peter Skov Jensen et al.
Experimental eye research, 179, 150-156 (2018-11-13)
Diabetic retinopathy is characterized by retinal lesions related to disturbances in retinal blood flow. The metabolic dysregulation in diabetes involves hyperglycemia which in both clinical and experimental studies has been shown to induce dilatation of larger retinal vessels, which has
Ziqing Li et al.
Acta physiologica (Oxford, England), 231(2), e13555-e13555 (2020-09-05)
By activating prostacyclin receptors (IP receptors), prostacyclin (PGI2 ) exerts cardiovascular protective effects such as vasodilation and inhibition of vascular smooth muscle cell (VSMC) proliferation. However, IP receptors are dysfunctional under pathological conditions, and PGI2 produces detrimental effects that are
Mohammed Saarti et al.
European journal of pharmacology, 896, 173917-173917 (2021-02-03)
In order to gain insight into the regulation of vascular tone by mitochondria, the effects of mitochondrial complex III inhibitors on contractile responses in porcine isolated coronary arteries were investigated. Segments of porcine coronary arteries were set up for isometric
Zane Stromberga et al.
BMC urology, 20(1), 48-48 (2020-05-01)
Inflammation is often associated with several bladder dysfunctions, including overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/PBS). As such, inflammation of the bladder and the actions of inflammatory mediators may contribute to the development of urinary symptoms. This study
Phillip G Kopf et al.
Endocrinology, 159(1), 238-247 (2017-11-01)
Hyperaldosteronism is associated with hypertension, cardiac hypertrophy, and congestive heart failure. Steroidogenic factors facilitate aldosterone secretion by increasing adrenal blood flow. Angiotensin (Ang) II decreases adrenal vascular tone through release of zona glomerulosa (ZG) cell-derived vasodilatory eicosanoids. However, ZG cell-mediated
Yacine Tabet et al.
American journal of physiology. Lung cellular and molecular physiology, 304(8), L562-L569 (2013-02-19)
Epoxyeicosanoids (EETs) are produced by cytochrome P-450 epoxygenase; however, it is not yet known what triggers their endogenous production in epithelial cells. The relaxing effects of bradykinin are known to be related to endogenous production of epithelial-derived hyperpolarizing factors (EpDHF).
Tomoaki Doi et al.
Prostaglandins, leukotrienes, and essential fatty acids, 87(2-3), 57-62 (2012-07-24)
We have previously shown that ristocetin, an activator of glycoprotein Ib/IX/V, induces release of soluble CD40 (sCD40) ligand via thromboxane (TX) A(2) production from human platelets. In the present study, we investigated the effect of antithrombin-III (AT-III), an anticoagulant, on
Nitin Puri et al.
Antioxidants & redox signaling, 18(5), 471-480 (2012-08-08)
Hydrogen peroxide (H(2)O(2)), a nonradical oxidant, is employed to ascertain the role of redox mechanisms in regulation of vascular tone. Where both dilation and constriction have been reported, we examined the hypothesis that the ability of H(2)O(2) to effect vasoconstriction
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