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Yoshiyuki Morishima et al.
American journal of clinical pathology, 143(2), 241-247 (2015-01-18)
Edoxaban, an oral direct factor Xa inhibitor, does not require routine monitoring. However, assessment of the anticoagulant effects may be required in certain situations. We investigated the effects of edoxaban on prothrombin time (PT), activated partial thromboplastin time (aPTT), and...
Jung-Heun Ha et al.
The Journal of nutrition, 144(6), 799-806 (2014-04-05)
Inflammation and endoplasmic reticulum (ER) stress are common denominators for vision-threatening diseases such as diabetic retinopathy and age-related macular degeneration. Based on our previous study, supplementation with muscadine grape polyphenols (MGPs) alleviated systemic insulin resistance and proinflammatory responses. In this...
R Cozzi et al.
Environmental and molecular mutagenesis, 26(3), 248-254 (1995-01-01)
Naturally occurring antimutagenic compounds are extensively analyzed for their capacity to protect cells from induced damage. We selected two agents, taurine and ellagic acid, treated in the literature as antioxidants, but whose activity is insufficiently known. This paper reports on...
Tony K McGhie et al.
Food & function, 3(11), 1170-1175 (2012-08-18)
We report the detection of JAK2 inhibitory activity in a Boysenberry (Rubus loganbaccus x R. baileyanus Britt.) drink using a combination of analytical-scale high performance liquid chromatography (HPLC) with a high-sensitivity time-resolved fluorescence coupled with fluorescence resonance energy transfer (TR-FRET)...
Bahaderjeet Singh et al.
Journal of ethnopharmacology, 194, 450-456 (2016-10-11)
Tinospora cordifolia (Willd. Hook. f. & Thomson; family: Menispermaceae), has a long history of use in various traditional medicinal systems including "Ayurveda". It is reported to possess anticancer, antidiabetic, antimicrobial, antispasmodic, and antiinflammatory activities. T. cordifolia has also been well...
Bing Tang et al.
International journal of cardiology, 180, 134-141 (2014-12-02)
Pulmonary artery hypertension (PAH) is characterized by vascular remodeling, high pulmonary blood pressure, and right ventricular hypertrophy. Oxidative stress, inflammation and pulmonary artery remodeling are important components in PAH. Ellagic acid (EA) is a phenolic compound with anti-oxidative, anti-inflammatory, and...
Coskun Usta et al.
International journal of food sciences and nutrition, 64(7), 907-913 (2013-05-25)
In recent years, the therapeutic use of non-drug substances such as herbal and medicinal foods is increasing progressively. Of these substances, Punica granatum L., which is an ancient and highly distinctive fruit, has been proposed for treatment of several different...
José Antonio Curiel et al.
Journal of agricultural and food chemistry, 57(14), 6224-6230 (2009-07-16)
Tannase is an enzyme with important biotechnological applications in the food industry. Previous studies have identified the tannase encoding gene in Lactobacillus plantarum and also have reported the description of the purification of recombinant L. plantarum tannase through a protocol...
V Arulmozhi et al.
Colloids and surfaces. B, Biointerfaces, 110, 313-320 (2013-06-05)
Ellagic acid (EA), a naturally occurring polyphenolic compound is well documented for its anticancer property in numerous pre-clinical models. The properties like poor water solubility and limited oral bio-availability of ellagic acid has hampered its clinical applications. The present study...
Patrice Njomnang Soh et al.
PloS one, 7(9), e45906-e45906 (2012-10-03)
The search for new antimalarial chemotherapy has become increasingly urgent due to parasite resistance to current drugs. Ellagic acid (EA) is a polyphenol, recently found in various plant products, that has effective antimalarial activity in vitro and in vivo without...
A Constantinou et al.
Nutrition and cancer, 23(2), 121-130 (1995-01-01)
Ellagic acid and 12 related agents have been tested for their ability to inhibit the activities of human DNA topoisomerase (topo) I and II. Using specific in vitro assays, we found ellagic acid and flavellagic acid to be potent inhibitors...
Sonia Trombino et al.
Anticancer research, 33(11), 4847-4854 (2013-11-14)
The aim of the present study was to prepare a hydrogel, based on ellagic acid and glycine, embedded with folic acid, as a subcutaneous implant for the treatment of breast cancer. The function of folic acid is to selectively and...
Tomoaki Haraguchi et al.
Journal of agricultural and food chemistry, 62(24), 5589-5594 (2014-05-27)
This study demonstrated that 0.5% dietary rutin, ellagic acid, or curcumin markedly increased cecal succinate levels in rats fed a high-fat diet, whereas catechin, caffeic acid, and quercetin did not. Other organic acids were modestly or hardly affected by polyphenols....
Shuang Zhang et al.
Molecules (Basel, Switzerland), 17(12), 13917-13922 (2012-11-28)
Four phenolic compounds were isolated from the roots of Sanguisorba officinalis L. by silica gel column chromatography and preparative HPLC. On the basis of chemical and spectroscopic methods, their structures were identified as methyl 4-O-β-D-glucopyranosy-5-hydroxy-3-methoxylbenzoate (1), 3,3′,4′-tri-O-methylellagic acid (2), fisetinidol-(4α-8)-catechin...
Saar Aharoni et al.
BioFactors (Oxford, England), 41(1), 44-51 (2015-02-05)
It was documented that pomegranate has anti-inflammatory effects. In this study, we investigated a direct effect of pomegranate juice (PJ) and its polyphenols on macrophage inflammatory phenotype. In vitro, PJ and its major polyphenols dose-dependently attenuated macrophage response to M1...
Xun Sun et al.
Food & function, 11(2), 1334-1348 (2020-02-12)
Huntington's disease (HD) is a genetic neurodegenerative disorder caused by a highly polymorphic CAG trinucleotide repeat expansion encoding an extended polyglutamine (polyQ) tract at the N-terminus of huntingtin protein (HTT). The polyQ tract promotes the formation of toxic oligomers and...
Ammar Altemimi et al.
Chemistry Central journal, 9, 39-39 (2015-06-25)
The use of medicinal plants has been reported throughout human history. In the fight against illnesses, medicinal plants represent the primary health care system for 60 % of the world's population. Flavonoids are polyphenolic compounds with active anti-microbial properties; they are...
Jieping Yang et al.
Food chemistry, 194, 1300-1303 (2015-10-17)
We investigated the effect of mixing soy protein isolate and pomegranate juice (PJ) on the bioavailability and metabolism of ellagitannins (ETs) in healthy volunteers. Eighteen healthy volunteers consumed PJ alone or PJ premixed with soy protein isolate (PJSP). The concentration...
Luciane de Lira Teixeira et al.
Journal of agricultural and food chemistry, 63(22), 5417-5427 (2015-05-21)
The grumixama (Eugenia brasiliensis Lam.), also known as Brazilian cherry, is a fruit native to Brazil. This study identified the flavonoids in the flesh and seeds and ellagitannin in the flesh of purple and yellow varieties. The physicochemical characteristics and...
Jing Zhao et al.
Food chemistry, 194, 167-174 (2015-10-17)
A total of 77 jujube, longan and chaste honey samples were collected from 18 different areas of China. Thirteen types of phenolic acids in the honey samples were analysed using high-performance liquid chromatography with electrochemical detection (HPLC-ECD). Moreover, HPLC-ECD fingerprints...
Amanda Dahl et al.
Journal of drugs in dermatology : JDD, 12(1), 52-58 (2013-02-05)
Hydroquinone (HQ) is the benchmark prescription agent for skin lightening. However, HQ use is recently banned in Europe and in parts of Asia because of potential long-term consequences, including carcinogenesis when orally consumed. This has resulted in development of alternative...
Yukihiro Yoshimura et al.
Biochemical and biophysical research communications, 434(3), 486-491 (2013-04-16)
Ellagic acid (EA) is a polyphenol found in a wide variety of plant foods that not only exhibits free radical-scavenging activity, but also confers protective effects against liver injury. Previously, we reported that pomegranate fruit extract (PFE) had an inhibitory...
N Al-Kharusi et al.
European review for medical and pharmacological sciences, 17(3), 299-310 (2013-02-22)
The anticancerdrug cisplatin (CP) causes nephrotoxicity through different mechanisms, including generation of free radicals. Ellagic acid (EA) is a polyphenolic antioxidant found in fruits and nuts. This study aimed to investigate the ability of different doses of EA to ameliorate...
C Kluft et al.
Thrombosis research, 135(1), 198-204 (2014-12-04)
It has recently been reported that factor XIa can activate factor X directly and can bypass factors VIII-IX. We evaluated the consequences for factor analysis with the one-stage APTT. APTT was performed with the Actin FS reagent with ellagic acid...
Ellagic acid protects against cisplatin-induced nephrotoxicity in rats: a dose-dependent study.
H Nasri
European review for medical and pharmacological sciences, 17(6), 849-850 (2013-04-24)
Yulin Ren et al.
Journal of medicinal chemistry, 49(9), 2829-2837 (2006-04-28)
The rapid increase of obesity-associated diabetes has created urgent demands for more effective antidiabetic therapies and pharmaceuticals that are able to address the problems of hyperglycemia and weight gain simultaneously. Our previous studies indicated that the alpha- and beta-anomers of...
Jatinder Rana et al.
Journal of cosmetic science, 64(6), 445-453 (2014-01-09)
Current efforts to develop effective skin lightening products through the inhibition of melanin production have focused on compounds that inhibit the function and activity of tyrosinase, the rate-limiting enzyme in the melanin biosynthesis pathway. Synthetic tyrosinase inhibitors, such as hydroquinone...
Bin Li et al.
Carbohydrate polymers, 92(2), 1443-1450 (2013-02-13)
Structurally varied, carboxyl-containing cellulose derivatives were evaluated for their ability to form amorphous solid dispersions (ASD) with ellagic acid (EA), in order to improve the solubility of this high-melting, poorly bioavailable, but highly bioactive natural flavonoid compound. ASDs of EA...
Rocío García-Villalba et al.
Journal of agricultural and food chemistry, 63(29), 6555-6566 (2015-07-15)
Pomegranates are one of the main highly valuable sources of ellagitannins. Despite the potential health benefits of these compounds, reliable data on their content in pomegranates and derived extracts and food products is lacking, as it is usually underestimated due...
Hyun Jik Lee et al.
Cell death and differentiation, 28(1), 184-202 (2020-07-25)
Hyperglycemia in diabetes mellitus (DM) patients is a causative factor for amyloidogenesis and induces neuropathological changes, such as impaired neuronal integrity, neurodegeneration, and cognitive impairment. Regulation of mitochondrial calcium influx from the endoplasmic reticulum (ER) is considered a promising strategy...
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