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Effective and safe gene-based delivery of GLP-1 using chitosanplasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes.
Jean M, Alameh M, Buschmann MD, Merzouki A.
Gene Therapy null
Daisuke Yabe et al.
Journal of diabetes investigation, 3(1), 70-79 (2012-02-20)
Aims/Introduction:  The effectiveness of incretin-based therapies in Asian type 2 diabetes requires investigation of the secretion and metabolism of glucose-dependent insulinotropic polypepide (GIP) and glucagon-like peptide 1 (GLP-1). Plasma extractions have been suggested to reduce variability in intact GLP-1 levels among individuals
A D Duncan et al.
Diabetic medicine : a journal of the British Diabetic Association, 37(10), 1705-1714 (2019-02-09)
To conduct a mixed-methods feasibility study of the effectiveness and acceptability of an individualized diet and physical activity intervention designed to reduce the risk of Type 2 diabetes experienced by people living with HIV. Participants with impaired fasting glucose and
Lorène J Lebrun et al.
Cell reports, 21(5), 1160-1168 (2017-11-02)
Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity. Here, we demonstrate that plasma GLP-1 levels are rapidly increased by lipopolysaccharide
Jae Woong Jeong et al.
International journal of molecular sciences, 21(11) (2020-06-03)
Glucagon-like peptide-1 (GLP-1) is a well-known incretin hormone secreted from enteroendocrinal L cells in response to nutrients, such as glucose and dietary fat, and controls glycemic homeostasis. However, the detailed intracellular mechanisms of how L cells control GLP-1 secretion in
Activity-induced GLP-1 release in lean and obese subjects.
Tanja C M Adam, Margriet S Westerterp-Plantenga
Physiology & Behavior null
Boris Le Nevé et al.
Regulatory peptides, 167(1), 14-20 (2010-11-13)
Enteroendocrine cells in the intestine sense the luminal contents and have been shown to respond to not only fatty acids, proteins, and monosaccharides but also artificial sweeteners and bitter compounds. Secretion of hormones such as CCK and GLP-1 from these
A Hochstenbach-Waelen et al.
Physiology & behavior, 101(2), 237-244 (2010-05-12)
In the short-term, gelatin showed stronger hunger suppression and less energy intake compared with other proteins. This study investigated if a supra-sustained gelatin-milk protein (GMP) diet improves weight maintenance (WM) compared with a sustained milk protein (SMP) diet and supra-sustained
Tomonori Hasegawa et al.
Journal of diabetes investigation, 10(2), 302-308 (2018-07-12)
It is reported that interfering substances in the blood might influence the value for measurement of active glucagon-like peptide-1 (GLP-1) in human plasma. Solid phase extraction (SPE) pretreatment is recommended to reduce their influence, but it requires a lot of
PPAR?/? Activation Induces Enteroendocrine L Cell GLP-1 Production.
Daoudi M, Hennuyer N, Borland MG, Touche V, Duhem C, Gross B, Caiazzo R, Kerr-Conte J et al.
Gastroenterology null
Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber.
Manuela P G M Lejeune, Klaas R Westerterp, Tanja C M Adam, Natalie D Luscombe-Marsh et al.
American Journal of Clinical Nutrition null
Effects of a supra-sustained gelatin-milk protein diet compared with (supra-)sustained milk protein diets on body-weight loss.
Ananda Hochstenbach-Waelen,Stijn Soenen,Klaas R Westerterp,Margriet S Westerterp-Plantenga
The British Journal of Nutrition null
Effects of high and normal soyprotein breakfasts on satiety and subsequent energy intake, including amino acid and 'satiety' hormone responses.
Margriet A B Veldhorst,Arie G Nieuwenhuizen,Ananda Hochstenbach-Waelen,Klaas R Westerterp et al.
European Journal of Nutrition null
Roger Reidelberger et al.
Physiological reports, 4(10) (2016-05-22)
Glucagon-like peptide-1 (GLP-1), peptide YY (3-36) [PYY(3-36)], amylin, ghrelin, insulin, and leptin are thought to act as hormonal signals from periphery to brain to control food intake. Here, we determined the effects of solid-phase extraction of plasma in measuring these
Decreased glucagon-like peptide 1 release after weight loss in overweight/obese subjects.
Tanja C M Adam, Johan Jocken, Margriet S Westerterp-Plantenga
Obesity Research null
Pimnapanut Sridonpai et al.
Journal of nutritional science, 10, e49-e49 (2021-07-23)
Postprandial hyperglycaemia is recognised as an important target in type 2 diabetes management. Dietary pattern, meal composition, and amount of food intake are major factors for maintaining postprandial blood glucose levels. The aim of this study was to investigate the
M van Avesaat et al.
International journal of obesity (2005), 39(2), 235-243 (2014-06-25)
Activation of the ileal brake, by infusing lipid directly into the distal part of the small intestine, alters gastrointestinal (GI) motility and inhibits food intake. The ileal brake effect on eating behavior of the other macronutrients is currently unknown. The
Parweez Koehestanie et al.
Endoscopy international open, 2(1), E21-E27 (2014-03-01)
Endoscopic implantation of a duodenal-jejunal bypass liner (DJBL) is a novel bariatric technique to induce weight loss and remission of type 2 diabetes mellitus. Placement of the DJBL mimics the bypass component of the Roux-en-Y gastric bypass (RYGB) procedure. In
Effects of oral fat perception by modified sham feeding on energy expenditure, hormones and appetite profile in the postprandial state.
Astrid J Smeets,Manuela P Lejeune,Margriet S Westerterp-Plantenga
The British Journal of Nutrition null
Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers.
T E Adrian,S Gariballa,K A Parekh,S A Thomas,H Saadi,J Al Kaabi,N Nagelkerke,B Gedulin,A A Young
Diabetologia null
Joanne M Donkers et al.
Cellular and molecular gastroenterology and hepatology, 10(3), 451-466 (2020-04-25)
Bile acids are important metabolic signaling molecules. Bile acid receptor activation promotes body weight loss and improves glycemic control. The incretin hormone GLP-1 and thyroid hormone activation of T4 to T3 have been suggested as important contributors. Here, we identify
Benjamin S Maciejewski et al.
World journal of gastrointestinal pathophysiology, 8(4), 161-175 (2017-12-01)
To examine the role that enzyme Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) plays in postprandial gut peptide secretion and signaling. The standard experimental paradigm utilized to evaluate the incretin response was a lipid challenge. Following a lipid challenge, plasma was collected via cardiac
Richard D Mattes et al.
Physiology & behavior, 120, 173-181 (2013-08-21)
Chewing reportedly contributes to satiation and satiety signals. Attempts to document and quantify this have led to small and inconsistent effects. The present trial manipulated oral processing effort though required chewing of gums of different hardness and measured appetitive sensations
Remi Kamakura et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 144, 132-138 (2019-09-16)
Novel treatment methods for obesity are urgently needed due to the increasing global severity of the problem. Gastrointestinal hormones, such as GLP-1 and PYY, are secreted by the enteroendocrine cells, playing a critical role in regulating food intake. Digested nutrients
Regular consumption of pulses for 8 weeks reduces metabolic syndrome risk factors in overweight and obese adults.
R C Mollard,B L Luhovyy,S Panahi,M Nunez,A Hanley,G H Anderson
The British Journal of Nutrition null
Shirley Vien et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 42(3), 302-310 (2017-02-09)
The effect of beverages commonly consumed by children in-between or with meals on short-term food intake (FI) and glycemic control has received little attention. Therefore, 2 experiments were conducted in 9- to 14-year-old children following a randomized repeated-measures design. Experiment
Ki-Suk Kim et al.
Scientific reports, 7(1), 13978-13978 (2017-10-27)
Odorants are non-nutrients. However, they exist abundantly in foods, wines, and teas, and thus can be ingested along with the other nutrients during a meal. Here, we have focused on the chemical-recognition ability of these ORs and hypothesized that the
Lulu Sun et al.
Nature medicine, 24(12), 1919-1929 (2018-11-07)
The anti-hyperglycemic effect of metformin is believed to be caused by its direct action on signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently, metformin was reported to alter the gut microbiota community in humans, suggesting that the hyperglycemia-lowering
Emily W Sun et al.
Diabetes, 66(8), 2144-2149 (2017-04-08)
Intestinal glucose stimulates secretion of the incretin hormone glucagon-like peptide 1 (GLP-1). The mechanisms underlying this pathway have not been fully investigated in humans. In this study, we showed that a 30-min intraduodenal glucose infusion activated half of all duodenal
Pim W Gilijamse et al.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 17(8), 1440-1448 (2021-06-05)
Glucagon-like peptide-1 (GLP-1) receptor agonist treatment is beneficial for the human glucose metabolism, and GLP-1 secretion is greatly enhanced following Roux-en-Y gastric bypass (RYGB). To elucidate the relationship between GLP-1 concentrations and insulin sensitivity in subjects with class II/III obesity
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