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Hamidreza Moghimi et al.
Iranian journal of pharmaceutical research : IJPR, 18(4), 2083-2092 (2020-03-19)
Nanoparticles are unique that enable many promising medical and technological applications in their physical, and chemical properties. It is widely accepted that nanoparticles should be thoroughly tested for health nanotoxicity, but a moderate risk analysis is currently prevented by a
Xiuya Yao et al.
Oxidative medicine and cellular longevity, 2020, 8348035-8348035 (2020-05-08)
Oxidative stress is an important factor of myocardial hypoxia/reoxygenation (H/R) injury. Our research focuses on how to reduce the cardiac toxicity caused by oxidative stress through natural plant extracts. Vanillic acid (VA) is a phenolic compound found in edible plants
Nasim Goudarzi et al.
Human cell, 33(2), 308-317 (2020-01-25)
There is a diverse population of stem cells in human breast milk that can be employed for therapeutic purposes as a reservoir of cells. The current study mainly aimed to determine the nature markers expressing on stem cells. For this
Yiyao Zhang et al.
Oncotarget, 6(12), 9999-10015 (2015-04-08)
Pancreatic ductal adenocarcinoma (PDA) is characterized by an extremely poor prognosis. An inflammatory microenvironment triggers the pronounced desmoplasia, the selection of cancer stem-like cells (CSCs) and therapy resistance. The anti-inflammatory drug aspirin is suggested to lower the risk for PDA
Somdeb BoseDasgupta et al.
FEBS letters, 588(21), 3898-3905 (2014-09-15)
Coronin 1 is a member of the evolutionarily conserved coronin protein family. Coronin proteins are characterized by the presence of a central WD repeat and a C-terminal coiled coil that in coronin 1 is responsible for trimerization. Coronin 1 was
Harshini Neelakantan et al.
Biochemical pharmacology, 163, 481-492 (2019-02-13)
Aging is accompanied by progressive declines in skeletal muscle mass and strength and impaired regenerative capacity, predisposing older adults to debilitating age-related muscle deteriorations and severe morbidity. Muscle stem cells (muSCs) that proliferate, differentiate to fusion-competent myoblasts, and facilitate muscle
Tobias Maetzig et al.
Molecular therapy. Methods & clinical development, 6, 54-65 (2017-07-01)
Tracking the behavior of leukemic samples both in vitro and in vivo plays an increasingly large role in efforts to better understand the leukemogenic processes and the effects of potential new therapies. Such work can be accelerated and made more efficient by
Yi Zhang et al.
Biochemical and biophysical research communications, 456(1), 139-144 (2014-12-03)
To evaluate the protective effect of the DPP IV inhibitor in STZ-induced islet injury and to identify the molecular events that protect islet against apoptosis. 4 diabetic monkeys were treated with streptozotocin (70 mg/kg) in the presence or absence of
Wonhwa Lee et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 26(6), 628-634 (2015-07-01)
Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain in physiological processes. However, there are limited modern data on its pharmacological effects and active components relating to its traditional use. Here, the anticoagulant and antiplatelet
Kuntal De et al.
Molecular cancer research : MCR, 17(7), 1519-1530 (2019-05-01)
Glioblastoma (GBM) is the most common and lethal primary brain tumor and remains incurable. This is in part due to the cellular heterogeneity within these tumors, which includes a subpopulation of treatment-resistant cells called cancer stem-like cells (CSC). We previously
Hao Meng et al.
Acta biomaterialia, 17, 160-169 (2015-02-14)
To decouple the extracellular oxidative toxicity of catechol adhesive moiety from its intracellular non-oxidative toxicity, dopamine was chemically bound to a non-degradable polyacrylamide hydrogel through photo-initiated polymerization of dopamine methacrylamide (DMA) with acrylamide monomers. Network-bound dopamine released cytotoxic levels of
Ingrid Cornax et al.
Microorganisms, 9(1) (2021-01-21)
Streptococcus canis is a common colonizing bacterium of the urogenital tract of cats and dogs that can also cause invasive disease in these animal populations and in humans. Although the virulence mechanisms of S. canis are not well-characterized, an M-like
Gábor Petővári et al.
Cancers, 12(9) (2020-09-10)
In spite of tremendous developments in breast cancer treatment, the relatively high incidence of relapsing cases indicates a great need to find new therapeutic strategies in recurrent, metastatic and advanced cases. The bioenergetic needs of growing tumours at the primary
Dandan Chen et al.
Biochimica et biophysica acta. Molecular basis of disease, 1865(6), 1253-1264 (2019-01-23)
NF-E2-related factor 2 (Nrf2) is a transcription factor playing cytoprotective effects in various pathological processes including oxidative stress and cardiac hypertrophy. Despite being a potential therapeutic target to treat several cardiomyopathies, the signaling underlying Nrf2-dependent cardioprotective action remains largely uncharacterized.
Hung-Jung Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(1), 279-284 (2013-12-18)
JMJD5, a Jumonji C domain-containing dioxygenase, is important for embryonic development and cancer growth. Here, we show that JMJD5 is up-regulated by hypoxia and is crucial for hypoxia-induced cell proliferation. JMJD5 interacts directly with pyruvate kinase muscle isozyme (PKM)2 to
Yu Sakuta et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 34(9), 1073-1078 (2018-05-29)
We have developed a microfluidic bioassay system that mimics glomerular filtration and tubular secretion in the kidney. The system consists of a peristaltic micropump (heart), a dialysis component (renal corpuscle), and a secretion component (renal proximal tubule). Analytes were separated
Vladimír Čermák et al.
Scientific data, 7(1), 160-160 (2020-05-29)
The plasticity of cancer cell invasion represents substantial hindrance for effective anti-metastatic therapy. To better understand the cancer cells' plasticity, we performed complex transcriptomic and proteomic profiling of HT1080 fibrosarcoma cells undergoing mesenchymal-amoeboid transition (MAT). As amoeboid migratory phenotype can
Franziska Greulich et al.
Cell reports, 34(6), 108742-108742 (2021-02-11)
Glucocorticoids (GCs) are effective anti-inflammatory drugs; yet, their mechanisms of action are poorly understood. GCs bind to the glucocorticoid receptor (GR), a ligand-gated transcription factor controlling gene expression in numerous cell types. Here, we characterize GR's protein interactome and find
Maya Idriss et al.
Biomolecules, 10(4) (2020-04-15)
Studies on tocotrienols have progressively revealed the benefits of these vitamin E isoforms on human health. Beta-tocotrienol (beta-T3) is known to be less available in nature compared to other vitamin E members, which may explain the restricted number of studies
Fanny Lebreton et al.
Diabetologia, 58(6), 1291-1299 (2015-03-20)
Ion fluxes constitute a major integrative signal in beta cells that leads to insulin secretion and regulation of gene expression. Understanding these electrical signals is important for deciphering the endogenous algorithms used by islets to attain homeostasis and for the
Eva Jover et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(8), 4459-4469 (2018-03-17)
Vascular smooth muscle cells (VSMCs) transdifferentiate into osteoblast-like cells during vascular calcification, inducing active remodeling and calcification of the extracellular matrix (ECM). Intracellular and extracellular enzymes, such as lysyl hydroxylase 1 (PLOD1) and lysyl oxidase (LOX), contribute to ECM maturation
Charlotte Vanacker et al.
The EMBO journal, 39(19), e104633-e104633 (2020-08-08)
Hypothalamic neurons expressing gonadotropin-releasing hormone (GnRH), the "master molecule" regulating reproduction and fertility, migrate from their birthplace in the nose to their destination using a system of guidance cues, which include the semaphorins and their receptors, the neuropilins and plexins
Stefano Di Biase et al.
PLoS biology, 15(3), e2001951-e2001951 (2017-03-31)
Fasting reduces glucose levels and protects mice against chemotoxicity, yet drugs that promote hyperglycemia are widely used in cancer treatment. Here, we show that dexamethasone (Dexa) and rapamycin (Rapa), commonly administered to cancer patients, elevate glucose and sensitize cardiomyocytes and
Marian Petrovic et al.
Cancer genomics & proteomics, 12(6), 347-358 (2015-11-07)
In the present article, we report on the semi-quantitative proteome analysis and related changes in protein expression of the MCF-7 breast cancer cell line following treatment with doxorubicin, using the precursor acquisition independent from ion count (PAcIFIC) mass spectrometry method.
Francesco Baino et al.
International journal of molecular sciences, 20(3) (2019-02-13)
Achieving the stable osteointegration of prosthetic implants is one of the great challenges of modern orthopedic surgery. The fixation of ceramic acetabular cups of hip joint prostheses is usually achieved using a metal shell provided with screws or pegs that
Jinyuan Li et al.
Life sciences, 224, 255-262 (2019-04-01)
To understand potential pro-oncological effects of lower dose paclitaxel treatment in cervical cancer cells, we investigated the potential roles of KRT17 on migration and proliferation of cervical cancer cells which might respond to cytoskeletal-based drugs treatments. We extracted the clinic
Areta M Czerwinska et al.
Cell cycle (Georgetown, Tex.), 15(21), 2931-2942 (2016-11-02)
The transcription factor Pax7 plays a key role during embryonic myogenesis and in adult organisms in that it sustains the proper function of satellite cells, which serve as adult skeletal muscle stem cells. Recently we have shown that lack of
Janine Aucamp et al.
Cellular and molecular life sciences : CMLS, 74(14), 2689-2707 (2017-03-21)
Although circulating DNA (cirDNA) analysis shows great promise as a screening tool for a wide range of pathologies, numerous stumbling blocks hinder the rapid translation of research to clinical practice. This is related directly to the inherent complexity of the
Dan Wei et al.
Life sciences, 247, 117414-117414 (2020-02-10)
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been reported to significantly reduce body weight. This study investigated whether SGLT2 inhibitors directly affect adipose tissues and the underlying mechanisms in vivo and in vitro. Male C57BL/6 mice were fed a normal diet
Jian-Long Xue et al.
Bioresource technology, 204, 130-138 (2016-01-17)
In this study, a co-production of two high value-added products, glucose and xylooligosaccharides (XOS), was investigated by utilizing sugarcane bagasse (SB) within a multi-product bio-refinery framework optimized by Box-Behnken design-based response surface methodology. The developed process resulted in a maximum
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