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Zhen Su et al.
American journal of physiology. Renal physiology, 312(6), F1128-F1140 (2017-04-07)
Chronic kidney disease (CKD) causes loss of lean body mass by multiple mechanisms. This study examines whether autophagy-mediated proteolysis contributes to CKD-induced muscle wasting. We tested autophagy in the muscle of CKD mice with plantaris muscle overloading to mimic resistance
Cindy Puente et al.
The Journal of biological chemistry, 291(11), 6026-6035 (2016-01-24)
Autophagy is a conserved catabolic process that utilizes a defined series of membrane trafficking events to generate a de novo double-membrane vesicle termed the autophagosome, which matures by fusing to the lysosome. Subsequently, the lysosome facilitates the degradation and recycling
Tuuli A Nissinen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(3), e21387-e21387 (2021-02-10)
Blocking of myostatin and activins effectively counteracts muscle atrophy. However, the potential interaction with physical inactivity and fasting in the regulation of muscle protein synthesis is poorly understood. We used blockade of myostatin and activins by recombinant adeno-associated virus (rAAV)-mediated
Hiroshi Itoh et al.
Journal of leukocyte biology, 98(1), 107-117 (2015-04-25)
Autophagy occurs in human neutrophils after the phagocytosis of multidrug-resistant bacteria and drug-sensitive strains, including Escherichia coli and Pseudomonas aeruginosa. The present study detected autophagy by immunoblot analysis of LC3B conversion, by confocal scanning microscopic examination of LC3B aggregate formation
Koji Yamano et al.
eLife, 7 (2018-01-24)
Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson's disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin ligase Parkin is important to trigger selective autophagy. Although
Yizhong Ren et al.
Journal of virology, 90(1), 591-598 (2015-10-16)
Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing
Scott P Holman et al.
Experimental neurology, 333, 113430-113430 (2020-08-04)
High-capacity mitochondrial calcium (Ca2+) uptake by the mitochondrial Ca2+ uniporter (MCU) is strategically positioned to support the survival and remyelination of axons in multiple sclerosis (MS) by undocking mitochondria, buffering Ca2+ and elevating adenosine triphosphate (ATP) synthesis at metabolically stressed
Yan-Bo Zhang et al.
Neuroscience bulletin, 24(3), 143-149 (2008-05-27)
To investigate changes of autophagy after traumatic brain injury (TBI) and its possible role. Rat TBI model was established by controlled cortical injury system. Autophagic double membrane structure was detected by transmission electronic microscope. Microtubule-associated protein 1 light chain 3
Ni Chen et al.
International journal of biological sciences, 11(7), 833-844 (2015-06-17)
Low-dose ionizing radiation (LDIR) can induce radio-resistance to following high dose radiation in various mammalian cells. The protective role of LDIR has been thought to be associated with the overall outcomes of cancer radiotherapy. NF-E2 related factor 2 (Nrf2) is
Xueping Wang et al.
Frontiers in microbiology, 9, 1091-1091 (2018-06-14)
Egg drop syndrome virus (EDSV) is an economically important pathogen with a broad host range, and it causes disease that leads to markedly decreased egg production. Although EDSV is known to induce apoptosis in duck embryo fibroblasts (DEFs), the interaction
Haijie Li et al.
American journal of physiology. Heart and circulatory physiology, 303(11), H1319-H1331 (2012-10-02)
Sonic hedgehog (Shh) is a morphogen critically involved in development that is reexpressed in atherosclerotic lesions. It also stimulates proliferation of vascular smooth muscle cells (SMCs). Autophagy in vascular SMCs is known to promote SMC survival and increase plaque stability.
Souad Amiar et al.
Cell reports, 30(11), 3778-3792 (2020-03-19)
Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine lipids from both host cell scavenging and de novo synthesis to maintain parasite propagation and survival within their human host. Major questions on the role and regulation of each
Aurore Claude-Taupin et al.
Nature cell biology, 23(8), 846-858 (2021-07-15)
The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad intracellular distribution and is present in numerous compartments, including the plasma membrane (PM). The reasons for the distribution of ATG9A to the PM and its
Yu Wu et al.
The FEBS journal, 287(15), 3184-3199 (2020-01-05)
The endo-lysosome system is involved in endocytosis, protein sorting, and degradation as well as autophagy. Numerous toxins and pathogens exploit this system to enter host cells and exert their deleterious effects. Modulation of host endo-lysosome pathway may restrict multiple toxins
Xin Zhu et al.
Experimental and therapeutic medicine, 13(5), 2348-2354 (2017-06-02)
The aim of the present study was to investigate the role of autophagy in celecoxib-induced apoptosis in human hormone-insensitive prostate cancer cell line PC3 cells and to explore the underlying molecular mechanism leading to autophagic activation. A cell viability assay
Karthikeyan Subburayan et al.
Translational oncology, 13(11), 100843-100843 (2020-08-18)
Ferroptosis is a novel form of programmed cell death characterized by an iron-dependent increase in reactive oxygen species (ROS). However, the role of ROS in the regulation of ferroptosis remains elusive. In this study, for the first time, we demonstrate
Michael P Nelson et al.
Acta neuropathologica communications, 2, 20-20 (2014-02-18)
Mutations in the gene for alpha-galactosidase A result in Fabry disease, a rare, X-linked lysosomal storage disorder characterized by a loss of alpha-galactosidase A enzymatic activity. The resultant accumulation of glycosphingolipids throughout the body leads to widespread vasculopathy with particular
Kai Liu et al.
Molecular cell, 68(2), 281-292 (2017-10-17)
Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. However, the mechanism is unclear. Here, we report that mitophagy, the selective removal of mitochondria by autophagy, positively regulates hepatic cancer stem cells (CSCs) by suppressing the
W Qiu et al.
Cell death & disease, 5, e1123-e1123 (2014-03-15)
Lysosomes are acidic organelles that have a crucial role in degrading intracellular macromolecules and organelles during the final stage of autophagy. Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, was reported as an autophagy activator. Here, in contrast with previous studies, we show
Maria A Gubbiotti et al.
The Journal of biological chemistry, 293(43), 16940-16950 (2018-07-28)
The extracellular matrix is a master regulator of tissue homeostasis in health and disease. Here we examined how the small, leucine-rich, extracellular matrix proteoglycan decorin regulates cardiomyocyte metabolism during fasting in vivo First, we validated in Dcn -/- mice that
Heme Induces BECN1/ATG5-Mediated Autophagic Cell Death via ER Stress in Neurons.
Yang, et al.
Neurotoxicity Research, 38, 1037-1048 (2020)
Valentina Naef et al.
International journal of molecular sciences, 22(16) (2021-08-28)
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a multisystem hereditary ataxia associated with mutations in SACS, which encodes sacsin, a protein of still only partially understood function. Although mouse models of ARSACS mimic largely the disease progression seen in
Seda Koyuncu et al.
Nature communications, 9(1), 2886-2886 (2018-07-25)
Induced pluripotent stem cells (iPSCs) undergo unlimited self-renewal while maintaining their potential to differentiate into post-mitotic cells with an intact proteome. As such, iPSCs suppress the aggregation of polyQ-expanded huntingtin (HTT), the mutant protein underlying Huntington's disease (HD). Here we
Guiping Luo et al.
International journal of molecular medicine, 43(5), 2033-2043 (2019-03-14)
Sirtuin 1 (Sirt1) exerts its cardioprotective effects in various cardiovascular diseases via multiple cellular activities. However, the therapeutic implications of Sirt1 in hypoxic cardiomyocytes and the underlying mechanisms remain elusive. The present study investigated whether Sirt1 regulates autophagy and apoptosis
Biserka Relic et al.
Oncotarget, 9(88), 35830-35843 (2018-12-12)
Phosphorylation of p62/SQSTM1 (p62) on Serine 349 (P-Ser349 p62) as well as proteasome dysfunction have been shown to activate the cell protective Keap1/Nrf2 pathway. We showed previously that BAY 11-7085-induced human synovial fibroblast cell death includes autophagy and p62 downregulation.
Shujuan Zhou et al.
Cellular & molecular biology letters, 26(1), 2-2 (2021-01-14)
Iron overload, which is common in patients with haematological disorders, is known to have a suppressive effect on haematogenesis. However, the mechanism for this effect is still unclear. The antioxidant curcumin has been reported to protect against iron overload-induced bone
Alberto Bresciani et al.
PloS one, 13(3), e0194423-e0194423 (2018-03-20)
Autophagy is a cellular mechanism that can generate energy for cells or clear misfolded or aggregated proteins, and upregulating this process has been proposed as a therapeutic approach for neurodegenerative diseases. Here we describe a novel set of LC3B-II and
Mads Skytte Rasmussen et al.
Autophagy, 13(5), 834-853 (2017-03-14)
The cysteine protease ATG4B cleaves off one or more C-terminal residues of the inactive proform of proteins of the ortholog and paralog LC3 and GABARAP subfamilies of yeast Atg8 to expose a C-terminal glycine that is conjugated to phosphatidylethanolamine during
David H Martínez-Puente et al.
Cell stress & chaperones, 24(1), 149-158 (2019-01-04)
Very promising results have been observed with a deoxyribonucleic acid (DNA) vaccine based on human papillomavirus type-16 (HPV-16) antigen retention and delivery system in the endoplasmic reticulum (ER). However, the mechanism by which these antigens are processed once they reach
Suzanne M Cloonan et al.
Nature medicine, 22(2), 163-174 (2016-01-12)
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have shown that IRP2 protein is increased in the lungs
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