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Weiyang He et al.
Autophagy, 8(12), 1811-1821 (2012-10-12)
Although it is known that tumor necrosis factor-related apoptosis-inducing ligand (TNFSF10/TRAIL) induces autophagy, the mechanism by which autophagy is activated by TNFSF10 is still elusive. In this report, we show evidence that TRAF2- and RIPK1-mediated MAPK8/JNK activation is required for
Elias Adriaenssens et al.
Scientific reports, 10(1), 8755-8755 (2020-05-31)
Three missense mutations targeting the same proline 209 (Pro209) codon in the co-chaperone Bcl2-associated athanogene 3 (BAG3) have been reported to cause distal myopathy, dilated cardiomyopathy or Charcot-Marie-Tooth type 2 neuropathy. Yet, it is unclear whether distinct molecular mechanisms underlie
Shaojin Zhang et al.
The British journal of nutrition, 106(2), 213-217 (2011-04-28)
Autophagy, a catabolic process responsible for the degradation of cytosolic components and the preservation of cellular homeostasis in virtually all eukaryotic organisms, is up-regulated when nutrient supplies are limited. However, whether early weaning induces autophagy in infants is not completely
Fan Zhang et al.
Journal of experimental & clinical cancer research : CR, 37(1), 135-135 (2018-07-05)
Expression of COP9 signalosome subunit 3 (COPS3), an oncogene overexpressed in osteosarcoma, has been demonstrated to be significantly correlated with tumor metastasis. However, the underlying mechanism by which COPS3 promotes metastasis of osteosarcoma and its role in autophagy remain unknown.
Kosmas Daskalakis et al.
Endocrine, 68(2), 438-447 (2020-03-03)
We assessed the levels of autophagy and mitophagy, that are linked to cancer development and drug resistance, in well differentiated pancreatic neuroendocrine neoplasms (PanNENs) and correlated them with clinico-pathological parameters. Fluorescent immunostaining for the autophagy markers LC3Β and p62/or LAMP1
Serena Castelli et al.
Journal of experimental & clinical cancer research : CR, 40(1), 94-94 (2021-03-13)
In the last decades, the concept of metabolic rewiring as a cancer hallmark has been expanded beyond the "Warburg effect" and the importance of other metabolic routes, including lipid metabolism, has emerged. In cancer, lipids are not only a source
Jacqueline Schmuckli-Maurer et al.
PloS one, 12(8), e0183797-e0183797 (2017-08-26)
Selective autophagy and related mechanisms can act as variable defense mechanisms against pathogens and can therefore be considered as intracellular immune responses. When in hepatocytes, Plasmodium parasites reside in a parasitophorous vacuole (PV) and the PV membrane (PVM) is the
Satoshi Tsukamoto et al.
Scientific reports, 4, 4533-4533 (2014-04-01)
Embryo quality is a critical parameter in assisted reproductive technologies. Although embryo quality can be evaluated morphologically, embryo morphology does not correlate perfectly with embryo viability. To improve this, it is important to understand which molecular mechanisms are involved in
Rui-Qiong Ba et al.
Neurological research, 42(4), 308-318 (2020-03-11)
Objectives: miR-199a can regulate autophagy, its underlying mechanisms remain unknown. The purpose of this study was to investigate the mechanisms of miR-199a involved in regulating autophagy in a 1-methyl-4-phenylpyridine (MPP+)-induced in vitro model of PD.Methods: PC12 cells were incubated in
Chih-Wen Shu et al.
Diagnostics (Basel, Switzerland), 11(2) (2021-03-07)
To investigate the association of autophagy-related gene expression with age-related macular degeneration (AMD). Patients with AMD were recruited for analysis by conjunctival impression cytology. mRNA was assessed by real-time polymerase chain reaction (RT-PCR) to evaluate whether the expression of 26
Chengyu Li et al.
Development (Cambridge, England), 147(13) (2020-07-06)
In mammalian growing follicles, oocytes are arrested at the diplotene stage (which resembles the G2/M boundary in mitosis), while the granulosa cells (GCs) continue to proliferate during follicular development, reflecting a cell cycle asynchrony between oocytes and GCs. Hypoxanthine (Hx)
Donghwi Bae et al.
The Journal of cell biology, 218(4), 1118-1127 (2019-02-23)
Cells respond to stress in the ER by initiating the widely conserved unfolded protein response. Activation of the ER transmembrane nuclease IRE1 leads to the degradation of specific mRNAs, but how this pathway affects the ability of cells to recover
Neale T Hanke et al.
Journal of cancer research and clinical oncology, 144(7), 1317-1327 (2018-05-17)
We previously showed that carfilzomib (CFZ) has potent anti-proliferative and cytotoxic activity in a broad range of lung cancer cell lines. Here we investigate possible mechanisms of CFZ acquired resistance in lung cancer cell lines. CFZ-resistant non-small cell lung cancer
H Lin et al.
Antimicrobial agents and chemotherapy, 63(1) (2018-10-31)
Nucleoside reverse transcriptase inhibitors (NRTI), such as zidovudine (AZT), are constituents of HIV-1 therapy and are used for the prevention of mother-to-child transmission. Prolonged thymidine analogue exposure has been associated with mitochondrial toxicities to heart, liver, and skeletal muscle. We
Rokeya Sultana Rekha et al.
Autophagy, 11(9), 1688-1699 (2015-07-29)
LL-37 is a human antimicrobial peptide (AMP) of the cathelicidin family with multiple activities including a mediator of vitamin D-induced autophagy in human macrophages, resulting in intracellular killing of Mycobacterium tuberculosis (Mtb). In a previous trial in healthy volunteers, we
Andrea Farini et al.
Frontiers in physiology, 11, 403-403 (2020-06-09)
Pentraxin 3 (PTX3) is a main component of the innate immune system by inducing complement pathway activation, acting as an inflammatory mediator, coordinating the functions of macrophages/dendritic cells and promoting apoptosis/necrosis. Additionally, it has been found in fibrotic regions co-localizing
Nuno Figueiredo et al.
Immunity, 39(5), 874-884 (2013-11-05)
Severe sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options in addition to organ support measures. Here we show that the clinically approved group of anthracyclines acts therapeutically at a low dose regimen
Sweta Sikder et al.
The FEBS journal, 286(22), 4422-4442 (2019-06-07)
Multifunctional human transcriptional positive co-activator 4 (PC4) is a bona fide nonhistone component of the chromatin and plays a pivotal role in the process of chromatin compaction and functional genome organization. Knockdown of PC4 expression causes a drastic decompaction which leads
Huiwen Song et al.
Autophagy, 15(8), 1419-1437 (2019-03-15)
N6-methyladenosine (m6A) mRNA modifications play critical roles in various biological processes. However, no study addresses the role of m6A in macroautophagy/autophagy. Here, we show that m6A modifications are increased in H/R-treated cardiomyocytes and ischemia/reperfusion (I/R)-treated mice heart. We found that
Yuan Peng et al.
Autophagy, 12(11), 2167-2182 (2016-11-02)
Autophagy critically contributes to metabolic reprogramming and chromosomal stability. It has been reported that monoallelic loss of the essential autophagy gene BECN1 (encoding BECN1/Beclin 1) promotes cancer development and progression. However, the mechanism by which BECN1 is inactivated in malignancy
Y Sun et al.
Cell death & disease, 5, e979-e979 (2014-01-05)
The transcription factor glioma-associated oncogene 1 (Gli1) has been recognized as a very important nuclear executor at the distal end of the Hedgehog (Hh) signal pathway, which has crucial roles in regulating many developmental processes, such as pattern formation, differentiation
Yan Shi et al.
PloS one, 7(11), e51076-e51076 (2012-12-12)
Oxaliplatin is included in a number of effective combination regimens used as first and subsequent lines of therapy for metastatic colorectal cancer. Accumulating evidence indicates that autophagy plays a significant role in response to cancer therapy. However, the role of
Weston W Blakeslee et al.
Journal of molecular and cellular cardiology, 112, 74-82 (2017-09-10)
Class I histone deacetylase (HDAC) inhibitors block hypertrophy and fibrosis of the heart by suppressing pathological signaling and gene expression programs in cardiac myocytes and fibroblasts. The impact of HDAC inhibition in unstressed cardiac cells remains poorly understood. Here, we
Hai-Yang Zheng et al.
Cancer biology & medicine, 9(2), 105-110 (2013-05-22)
To investigate LC3B-II and active caspase-3 expression in human colorectal cancer to elucidate the role of autophagy, and to explore the relationship of autophagy with apoptosis in human colorectal cancer. LC3B expression was detected by immunohistochemistry in 53 human colorectal
Zhe-Wei Zhang et al.
The Tohoku journal of experimental medicine, 246(2), 87-96 (2018-10-20)
MicroRNAs (miRNAs) are small noncoding RNA molecules that participate in normal B cell lineage development through posttranscriptional gene regulation. Antibody-mediated renal allograft rejection (ABMR) is emerging as one of the most common serious threats to renal transplant patients. In this
Renyan Li et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(1), 29-41 (2018-07-12)
The effects of exposure to radiofrequency electromagnetic fields (RF-EMFs) on the male reproductive system have raised public concern and studies have shown that exposure to RF-EMFs can induce DNA damage and autophagy. However, there are no related reports on the
Jamal Alfaisal et al.
Biology of the cell, 111(12), 308-318 (2019-10-20)
Autophagy is induced during HIV-1 entry into CD4 T cells by the fusion of the membranes triggered by the gp41 envelope glycoprotein. This anti-HIV-1 mechanism is inhibited by the viral infectivity factor (Vif) neosynthesized after HIV-1 integration to allow viral replication.
Lele Wang et al.
Reproductive sciences (Thousand Oaks, Calif.), 27(8), 1665-1672 (2020-05-21)
The purpose of this study was to analyze the autophagy of the human uterine myometrium during the labor. We collected uterine myometrium strips from term, singleton, nulliparous healthy women undergoing cesarean delivery before labor (nonlabor group, n = 10) or
José A Martina et al.
Science signaling, 7(309), ra9-ra9 (2014-01-23)
The discovery of a gene network regulating lysosomal biogenesis and its transcriptional regulator transcription factor EB (TFEB) revealed that cells monitor lysosomal function and respond to degradation requirements and environmental cues. We report the identification of transcription factor E3 (TFE3)
Guoyuan Pan et al.
Life sciences, 243, 117279-117279 (2020-01-12)
Treadmill exercise is a beneficial treatment following childhood stroke. Thus, studies focusing on the neuroprotective mechanism of exercise training during postischemic treatment in children with ischemic stroke are urgently needed. We evaluated the effects of treadmill exercise on autophagy after
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