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Benping Zhang et al.
Pharmaceutical biology, 53(4), 503-511 (2014-11-08)
Mangiferin (2-C-β-d-gluco-pyranosyl-1,3,6,7-tetrahydroxyxanthone) is a well-known natural antioxidant distributed in various plants of the Anacardiaceae and Gentianaceae families. Mangiferin can inhibit carcinogen-induced lung or colon tumor formation in experimental animals. However, the molecular mechanisms of its chemopreventive activity remain unexplored. This...
Theresa Beelders et al.
Journal of agricultural and food chemistry, 63(22), 5518-5527 (2015-05-15)
Degradation of the major benzophenones, iriflophenone-3-C-glucoside-4-O-glucoside and iriflophenone-3-C-glucoside, and the major xanthones, mangiferin and isomangiferin, of Cyclopia genistoides followed first-order reaction kinetics during high-temperature oxidation of the plant material at 80 and 90 °C. Iriflophenone-3-C-glucoside-4-O-glucoside was shown to be the...
Mani Kavitha et al.
Chemico-biological interactions, 206(2), 239-247 (2013-10-08)
Mangiferin, a polyphenol compound of C-glucoside, is well-known for its anti-inflammatory, antioxidant, anticancer, antidiabetic and cognitive enhancement properties. In this study, we investigated the neuroprotective effect of mangiferin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD), which is most...
Siddaruda M Biradar et al.
European journal of pharmacology, 683(1-3), 140-147 (2012-03-20)
The present study was conducted to evaluate the neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines along with its antioxidant status. Scopolamine and natural aging were employed as an experimental amnesia inducing agents. The tested dose of...
Bin Wang et al.
International immunopharmacology, 25(1), 148-154 (2014-12-07)
Ischemia reperfusion injury (IRI) is a leading cause of acute kidney injury, which is associated with high morbidity. The aims of the present study were to examine whether mangiferin attenuates renal IRI in an animal model and to identify the...
Susanna Phoboo et al.
Phytotherapy research : PTR, 27(2), 227-235 (2012-04-24)
The crude extract of Swertia chirayita, an important medicinal plant of Nepal, is locally used for many diseases including type 2 diabetes. In this study, crude aqueous and 12% ethanol solution extracts of S. chirayita collected from nine districts of Nepal...
Jiajia Wang et al.
Journal of agricultural and food chemistry, 63(45), 10013-10021 (2015-10-22)
Prevention of the occurrence and development of inflammation is a vital therapeutic strategy for treating acute lung injury (ALI). Increasing evidence has shown that a wealth of ingredients from natural foods and plants have potential anti-inflammatory activity. In the present...
Hui-Seong Kim et al.
European journal of pharmacology, 689(1-3), 38-44 (2012-06-12)
Chronic exposure of human skin to solar ultraviolet (UV) radiation causes photoaging. Naturally occurring phytochemicals are known to have anti-photoaging effects. The present study examined the effect of mangiferin isolated from Anemarrhena asphodeloides on wrinkle formation, skin thickness, and changes...
Bosai He et al.
Journal of mass spectrometry : JMS, 47(10), 1333-1340 (2012-09-29)
Suan-Zao-Ren (SZR) decoction, consisting of Ziziphi Spinosae Semen, Poria, Chuanxiong Rhizoma, Anemarrhenae Rhizoma and Glycyrrhizae Radix Et Rhizoma, is a Traditional Chinese Medicine prescription, clinically used for the treatment of insomnia. The objective of this study was to develop a...
Prajapati Kasbe et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 31, 107-112 (2015-05-26)
Mangiferin is a phytochemical primarily present in the stem, leaves and bark of Mangifera indica. It offers neuroprotection mainly through inhibition of oxidative stress, and decreasing proinflammatory cytokines level in the brain. Aluminium has been reported to cause oxidative stress-associated...
Xiaoli Wang et al.
Drug development and industrial pharmacy, 39(9), 1408-1413 (2012-07-24)
The therapeutic efficiency of mangiferin is restricted by its low intestinal permeability. In order to improve the oral absorption of mangiferin, potential of enhancers, including TPGS, sodium deoxycholate and Carbopol 974P, were investigated in a series of in vivo experiments....
Jian-Min Shen et al.
International journal of pharmaceutics, 427(2), 400-409 (2012-02-22)
In this work, the chitosan-based luminescent/magnetic (CLM) nanomaterials were synthesized by direct gelation of chitosan, CdTe and superparamagnetic iron oxide into the hybrid nanogels. The morphology, sizes and properties of the nanogels prepared with different chitosan/QD/MNP ratios and under different...
Zulfaqar Dudhia et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(5), 401-408 (2013-02-23)
The stems, leaves and flowers of Cyclopia have been consumed as a herbal tea 'honeybush tea' to treat various medical ailments since the 19th century. Plant polyphenols are reported to inhibit adipogenesis in cell and animal models of obesity. The...
Jinsong Xiao et al.
Oncology reports, 33(6), 2815-2820 (2015-04-23)
Mangiferin, a flavonoid extracted from the leaves of the Anacardiaceae plant, the mango tree, has physiological activity and pharmacological effects in many aspects. The present study aimed to clarify the effect of mangiferin on proliferation and apoptosis of glioma cells...
Md Shamim Rahman et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 141, 111415-111415 (2020-05-18)
Mangiferin (MF) from Mangifera indica has been serendipitously found to ameliorate obesity and is used as an antioxidant, anti-inflammatory, antimicrobial, and anticancer agent. Nonetheless, the mechanism of MF-induced brown-adipose-tissue activation has not been studied. Therefore, we investigated the effect of...
Yang Luo et al.
Molecular medicine reports, 12(5), 7132-7138 (2015-09-02)
Mangiferin has antioxidant, antiviral, apoptosis regulating, anti‑inflammatory, antitumor and antidiabetic effects, which can also inhibit osteoclast formation and bone resorption. However, whether mangiferin ameliorates the neurological pain of spinal cord injury (SCI) in ratS remains to be elucidated. The present...
Extraction of mangiferin from Mangifera indica leaves using three phase partitioning coupled with ultrasound
Kulkarni VM and Rathod VK
Industrial Crops and Products, 52, 292-297 (2014)
Dezhi Zheng et al.
Pharmacology, 90(1-2), 78-87 (2012-07-05)
The purpose of this study was to clarify the protective role of mangiferin on postinfarction myocardial remodeling and potential mechanisms. The myocardial infarction (MI) model was established by ligating the left anterior descending coronary artery. Cardiac function, myocardial apoptosis and...
Rui Liu et al.
Journal of pharmaceutical sciences, 101(10), 3833-3844 (2012-07-07)
The aim of this study was to develop a novel nanostructured lipid carriers (NLCs) system to improve ocular bioavailability of mangiferin (MGN) for the potential treatment of cataract. The physicochemical properties of MGN-loaded NLC (MGN-NLC) formulation were characterized by particle...
Mieczyslaw Pokorski et al.
Advances in experimental medicine and biology, 758, 373-380 (2012-10-20)
Reactive oxygen species favor the reductive state of iron. Antioxidation, by depleting biologically active ferrous iron, could then have a stabilizing effect, akin to hypoxia, on HIF-1α; the process which controls the genetic responses to hypoxia. However, the influence of...
M Mortimer et al.
PloS one, 10(7), e0132950-e0132950 (2015-07-25)
The genus Cyclopia, an indigenous South African fynbos plant used to prepare honeybush tea, contains phytoestrogenic compounds. An extract from C. subternata, SM6Met, displays three desirable estrogenic attributes for future development of a phytoestrogenic nutraceutical, namely, ERα antagonism, ERβ agonism...
Claudine Campa et al.
Annals of botany, 110(3), 595-613 (2012-06-16)
The phenolic composition of Coffea leaves has barely been studied, and therefore this study conducts the first detailed survey, focusing on mangiferin and hydroxycinnamic acid esters (HCEs). Using HPLC, including a new technique allowing quantification of feruloylquinic acid together with...
Joydeep Das et al.
Toxicology and applied pharmacology, 260(1), 35-47 (2012-02-09)
Mangiferin, a xanthone glucoside, is well known to exhibit antioxidant, antiviral, antitumor, anti-inflammatory and gene-regulatory effects. In the present study, we isolated mangiferin from the bark of Mangifera indica and assessed its beneficial role in galactosamine (GAL) induced hepatic pathophysiology....
Jun Hou et al.
Pharmacology, 90(3-4), 177-182 (2012-09-06)
In this study, we combined the dipeptidyl peptidase-4 inhibitor sitagliptin with the antidiabetic drug mangiferin to examine the effects on active glucagon-like peptide-1 (GLP-1) and glucose tolerance in streptozotocin-diabetic rats. Active GLP-1 levels were measured by an ELISA kit. Insulin...
Fuchsia Gold-Smith et al.
Nutrients, 8(7) (2016-07-02)
Mangiferin, a bioactive compound derived primarily from Anacardiaceae and Gentianaceae families and found in mangoes and honeybush tea, has been extensively studied for its therapeutic properties. Mangiferin has shown promising chemotherapeutic and chemopreventative potential. This review focuses on the effect...
Periyar Selvam Sellamuthu et al.
Pakistan journal of pharmaceutical sciences, 27(1), 161-167 (2014-01-01)
Salacia chinensis L. is a traditional Southeast Asian herbal medicine and used in the treatment of diabetes. To investigate the antidiabetic properties of mangiferin from Salacia chinensis and its beneficial effect on toxicological and hematological parameters in streptozotocin induced diabetic...
Gorawit Yusakul et al.
Journal of food science, 77(4), C414-C419 (2012-03-08)
An enzyme-linked immunosorbent assay (ELISA) was developed for determining mangiferin content in plant samples using a polyclonal antibody (PAb) against mangiferin. The developed ELISA showed a full measurement range from 0.12 to 31.25 μg/mL mangiferin with a relative standard deviation...
Jixiao Lei et al.
Journal of cellular biochemistry, 113(8), 2633-2642 (2012-03-17)
Recent studies suggest that mangiferin aglycone (norathyriol) has great potential as a novel radioprotector without any known toxic side effects. In this study, we assessed the protective effects of mangiferin aglycone against radiation-induced injuries on normal human intestinal epithelial cells...
Junna Song et al.
Metabolism: clinical and experimental, 64(3), 428-437 (2014-12-17)
Endothelial dysfunction is tightly associated with cardiovascular complications in diabetic patients. This study aims to investigate the effects of mangiferin on the regulation of endothelial homeostasis under endoplasmic reticulum stress (ER stress) conditions. High glucose (25 mmol/L) exposure induced ER...
Xiao-yu Xuan et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(9), 1508-1511 (2013-03-05)
To study formulation of self-microemulsifying drug delivery system (SMEDDS) of mangiferin phospholipid complex and improve dissolution and bioavailability of mangiferin. Ternary phase diagram was applied to optimize the prescription of self-microemulsifying drug delivery system of mangiferin phospholipid complex, and the...
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