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Prateek Kakar et al.
Journal of controlled release : official journal of the Controlled Release Society, 319, 428-437 (2020-01-11)
Traditional patches are most successful in transdermal delivery of low-dose hydrophobic drugs. Week-long transdermal delivery of high-dose hydrophilic drugs remains a big challenge. This study explored ablative fractional laser (AFL) to assist 3-day to week-long sustained transdermal delivery of powder
Wioleta Chajęcka-Wierzchowska et al.
Food microbiology, 46, 222-226 (2014-12-06)
The aim of this work was to study the pheno- and genotypical antimicrobial resistance profile of coagulase negative staphylococci (CoNS) isolated from 146 ready-to-eat food of animal origin (cheeses, cured meats, sausages, smoked fishes). 58 strains were isolated, they were
Qian Wang et al.
Biomaterials, 35(29), 8385-8393 (2014-07-06)
Microparticle-based vaccine delivery systems are known to promote enhanced immune responses to protein antigens and can elicit TH1-biased responses when used in combination with Toll-like receptor (TLR) agonists. It is important to understand the kinetics of the immune responses to
Isabel Silva et al.
The Journal of urology, 194(4), 1146-1154 (2015-05-26)
Deregulation of purinergic bladder signaling may contribute to persistent detrusor overactivity in patients with bladder outlet obstruction. Activation of uridine diphosphate sensitive P2Y6 receptors increases voiding frequency in rats indirectly by releasing adenosine triphosphate from the urothelium. To our knowledge
Mie Kristensen et al.
The AAPS journal, 17(5), 1200-1209 (2015-05-21)
Penetratin is a widely used carrier peptide showing promising potential for mucosal delivery of therapeutic proteins. In the present study, the importance of specific penetratin residues and pH was investigated with respect to complexation with insulin and subsequent transepithelial insulin
J A Davis et al.
Letters in applied microbiology, 59(1), 1-8 (2014-04-16)
Antimicrobial-resistant staphylococci have been associated with wounded or ill companion animals, but little is known about the prevalence of resistant staphylococci among healthy animals. In this study, 276 healthy dogs and cats from veterinary clinics were tested for the presence
Norisuke Shibuya et al.
Oncology, 88(5), 309-319 (2015-01-17)
Glycolysis and the pentose phosphate pathway (PPP) are preferentially activated in cancer cells. Accumulating evidence indicated the significance of the altered glucose metabolism in cancer, but the implication for oncotherapy remains unclear. Here we report that the synthesis of glycolytic
Filipa I Baptista et al.
Experimental eye research, 127, 91-103 (2014-07-30)
Diabetic retinopathy is a leading cause of vision loss and blindness. Disruption of axonal transport is associated with many neurodegenerative diseases and might also play a role in diabetes-associated disorders affecting nervous system. We investigated the impact of type 1
Ibukun Afolami et al.
PloS one, 16(9), e0253436-e0253436 (2021-09-21)
This study aimed to uncover the effect of voided urinary volume on small intestine permeability ratios in healthy children. We assessed small intestine permeability in 155 apparently healthy children, aged 3-5 years old, without any visible symptoms of disease, in
Coupling of energy to D-mannitol transport in Escherichia coli.
G R Jacobson
Research in microbiology, 141(3), 365-368 (1990-03-01)
Ying-Lien Chen et al.
PloS one, 10(1), e0116974-e0116974 (2015-01-21)
ScOpi1p is a well-characterized transcriptional repressor and master regulator of inositol and phospholipid biosynthetic genes in the baker's yeast Saccharomyces cerevisiae. An ortholog has been shown to perform a similar function in the pathogenic fungus Candida glabrata, but with the
Trevor M Nolan et al.
Developmental cell, 41(1), 33-46 (2017-04-12)
Plants encounter a variety of stresses and must fine-tune their growth and stress-response programs to best suit their environment. BES1 functions as a master regulator in the brassinosteroid (BR) pathway that promotes plant growth. Here, we show that BES1 interacts
Sebastian Koob et al.
Biochimica et biophysica acta, 1853(7), 1551-1563 (2015-03-15)
Mitochondrial membrane architecture is important for organelle function. Alterations thereof are linked to a number of human disorders including diabetes and cardiomyopathy. The MICOS complex was recently reported to be a central player determining cristae structure and formation of crista
Francisco J Prado-Prado et al.
Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27)
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability with which a drug is active against
Noriaki Nagai et al.
Journal of oleo science, 64(7), 743-750 (2015-07-03)
We investigated the protective effects of mannitol on corneal damage caused by benzalkonium chloride (BAC), which is used as a preservative in commercially available timolol maleate eye drops, using rat debrided corneal epithelium and a human cornea epithelial cell line
Rostyslav R Panchuk et al.
Free radical biology & medicine, 106, 134-147 (2017-02-13)
Landomycin E (LE) is an angucycline antibiotic produced by Streptomyces globisporus. Previously, we have shown a broad anticancer activity of LE which is, in contrast to the structurally related and clinically used anthracycline doxorubicin (Dx), only mildly affected by multidrug
Pär Matsson et al.
Journal of medicinal chemistry, 48(2), 604-613 (2005-01-22)
The influence of different drug transport routes in intestinal drug permeability screening assays was studied. Three experimental models were compared: the small-intestine-like 2/4/A1 cell model, which has a leaky paracellular pathway, the Caco-2 cell model, which has a tighter paracellular
Marie Guhmann et al.
Drug development and industrial pharmacy, 41(4), 540-551 (2014-02-06)
Fast onset of action is prerequisite for acute pain medication. A palatable orodispersible medicine of diclofenac providing rapid analgesic effect should improve patient compliance and treatment. In the present study, diclofenac taste-masked orodispersible tablets (ODTs) with fast release characteristics were
Valeria Velasco et al.
PloS one, 9(5), e97617-e97617 (2014-05-23)
The aim of this study was to compare a real-time PCR assay, with a conventional culture/PCR method, to detect S. aureus, mecA and Panton-Valentine Leukocidin (PVL) genes in animals and retail meat, using a two-step selective enrichment protocol. A total
Tie Yi Kiew et al.
International journal of pharmaceutics, 484(1-2), 115-123 (2015-03-01)
While the supersaturation generation capability of amorphous nanopharmaceuticals (NPs) in their aqueous suspension form has been well established, their supersaturation generation is adversely affected after drying. Herein we investigated the effects of freeze drying on the supersaturation generation capability of
T Narender et al.
Bioorganic & medicinal chemistry letters, 21(21), 6393-6397 (2011-09-21)
In continuation of our drug discovery program on metabolic diseases, we identified an alkaloidal amide, that is, Aegeline (V) from the plant Aegle marmelos leaves as a dual acting agent (antihyperlipidemic and antihyperglycemic). We therefore synthesized a series of alkaloidal
Hjalte Trnka et al.
Pharmaceutical development and technology, 20(1), 65-73 (2014-01-15)
Freeze-drying in presence of excipients is a common practice to stabilize biomacromolecular formulations. The composition of this formulation is known to affect the quality of the final product. The aim of this study was to evaluate freeze-drying in well-plates as
Lene Myhren et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(1), 186-193 (2014-04-22)
Despite recent advances in chemotherapy against acute myeloid leukaemia (AML), the disease still has high mortality, particularly for patients who tolerate extensive chemotherapy poorly. Nano-formulations have potential to minimise the adverse effects of chemotherapy. We present here a liposomal formulation
Roberto Rangel et al.
Nature protocols, 8(10), 1916-1939 (2013-09-14)
Techniques that are largely used for protein interaction studies and the discovery of intracellular receptors, such as affinity-capture complex purification and the yeast two-hybrid system, may produce inaccurate data sets owing to protein insolubility, transient or weak protein interactions or
Hjalte Trnka et al.
Journal of pharmaceutical sciences, 103(9), 2839-2846 (2014-03-26)
Evaluation of freeze-dried biopharmaceutical formulations requires careful analysis of multiple quality attributes. The aim of this study was to evaluate the use of near-infrared (NIR) imaging for fast analysis of water content and related physical properties in freeze-dried formulations. Model
Takalani Theka et al.
Urolithiasis, 41(2), 111-117 (2013-03-19)
It is well established that calcium oxalate stones may be caused by colonic or ileum oxalate (Ox) hyperabsorption (secondary to intestinal dysfunction). Studies have reported that increased intestinal permeability (IP) can cause hyperabsorption of nutrients culminating in passive diffusion of
Simonetta Visintin et al.
International journal of food microbiology, 216, 69-78 (2015-10-02)
Yeast, lactic acid bacteria (LAB) and acetic acid bacteria (AAB) populations, isolated from cocoa bean heap and box fermentations in West Africa, have been investigated. The fermentation dynamicswere determined by viable counts, and 106 yeasts, 105 LAB and 82 AAB
Juerg Barben et al.
Pediatric pulmonology, 36(6), 490-494 (2003-11-18)
Our objective was to determine the repeatability of bronchial responsiveness to mannitol dry powder (MDP) as an objective marker of asthma in children. MDP challenge was performed in children with stable asthma at the same time of the day on
Matthias Erber et al.
International journal of pharmaceutics, 495(2), 692-700 (2015-09-24)
A cryopellet formulation of the diagnostic protein ecarin has been developed that is suitable for use to monitor blood coagulation via in vitro thromboelastometry. The coagulation activity of the ecarin was measured by thromelastometry using whole blood. In aqueous solution
Kim Tardif et al.
Cardiovascular diabetology, 13, 119-119 (2014-08-21)
Nestin was reported to directly contribute to cell proliferation and the intermediate filament protein was detected in vascular smooth muscle cells. In experimental type I diabetes, nestin downregulation in the heart was identified as an incipient pathophysiological event. The following
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