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MDQ1

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Luciane Tsukamoto Kagohara et al.
Future oncology (London, England), 11(2), 233-249 (2014-07-30)
The aim of the study was to evaluate the use of global and gene-specific DNA methylation changes as potential biomarkers for gallbladder cancer (GBC) in a cohort from Chile. DNA methylation was analyzed through an ELISA-based technique and quantitative methylation-specific...
Marjan M Tajrishi et al.
The Journal of biological chemistry, 289(29), 19985-19999 (2014-06-05)
The TWEAK-fibroblast growth factor-inducible 14 (Fn14) system is a critical regulator of denervation-induced skeletal muscle atrophy. Although the expression of Fn14 is a rate-limiting step in muscle atrophy on denervation, mechanisms regulating gene expression of Fn14 remain unknown. Methylation of...
Puleng Matatiele et al.
Journal of biomedical science, 22, 34-34 (2015-05-20)
Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are systemic autoimmune connective tissue diseases that share overlapping clinico-pathological features. It is highly probable that there is an overlap in epigenetic landscapes of both diseases. This study aimed to identify similarities...
Cristina Sanchez-Fernandez et al.
Cell death & disease, 10(5), 347-347 (2019-04-27)
The primordium of the limb contains a number of progenitors far superior to those necessary to form the skeletal components of this appendage. During the course of development, precursors that do not follow the skeletogenic program are removed by cell...
Rafael Guerrero-Preston et al.
Epigenetics, 5(6), 539-546 (2010-06-05)
Environmental exposures in-utero may alter the epigenome, thus impacting chromosomal stability and gene expression. We hypothesized that in utero exposures to maternal smoking and perfluoroalkyl compounds (PFCs) are associated with global DNA hypomethylation in umbilical cord serum. Our objective was...
Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis.
Lanlan Shen et al.
BioTechniques, 42(1), 48-48 (2007-02-03)
Dina Bellizzi et al.
Epigenomics, 4(1), 17-27 (2012-02-16)
In the present study, we investigated whether global DNA methylation levels are affected by mitochondrial DNA (mtDNA) variants, which are known to modulate mitochondrial functions. Global DNA methylation levels were evaluated in peripheral blood DNA collected from adult subjects and...
Alison G Greene et al.
Experimental eye research, 201, 108349-108349 (2020-11-15)
Pseudoexfoliation syndrome (PXF) is the most common cause of secondary open angle glaucoma worldwide. Single nucleotide polymorphisms (SNPs) in the gene Lysyl oxidase like 1 (LOXL1) are strongly associated with the development of pseudoexfoliation glaucoma (PXFG). However, these SNPs are...
Fiona McDonnell et al.
PloS one, 11(4), e0153354-e0153354 (2016-04-29)
Fibrosis and a hypoxic environment are associated with the trabecular meshwork (TM) region in the blinding disease glaucoma. Hypoxia has been shown to alter DNA methylation, an epigenetic mechanism involved in regulating gene expression such as the pro-fibrotic transforming growth...
Magdalena Gryzinska et al.
Biochemical genetics, 51(7-8), 554-563 (2013-04-05)
DNA methylation is an epigenetic modification that plays an important role in the normal development and function of organisms. The level of DNA methylation is species-, tissue-, and organelle-specific, and the methylation pattern is determined during embryogenesis. DNA methylation has...
Resistance training and redox homeostasis: Correlation with age-associated genomic changes
Dimauro I, et al.
Redox Biology, 10, 34-44 (2016)
L V Toffoli et al.
Behavioural brain research, 265, 142-147 (2014-03-04)
Fluoxetine is an antidepressant that has been largely used for treatment of depression in pregnancy. In the present study we evaluated the effects of the exposure to fluoxetine during gestation and lactation on DNA methylation of rat brain regions. Female...
Gelson M Rodrigues et al.
Behavioural brain research, 279, 123-128 (2014-12-03)
The vulnerability of epigenetic marks of brain cells to environmental stimuli and its implication for health have been recently debated. Thus, we used the rat model of acute restraint stress (ARS) to evaluate the impact of stress on the global...
Nayana A Patil et al.
International journal of nanomedicine, 11, 4509-4519 (2016-09-24)
Titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles (NPs) are promising candidates for numerous applications in consumer products. This will lead to increased human exposure, thus posing a threat to human health. Both these types of NPs have been studied...
Aneta Strachecka et al.
PloS one, 12(4), e0176539-e0176539 (2017-04-28)
We examined age-related biochemical and histological changes in the fat bodies and hemolymph of Osmia rufa males and females. We analysed solitary bees during diapause, in October and in April; as well as the flying insects following diapause, in May...
Francesca Pirini et al.
Oncotarget, 8(24), 38501-38516 (2017-04-19)
Clinically useful molecular tools to triage gastric cancer patients are not currently available. We aimed to develop a molecular tool to predict gastric cancer risk in endoscopy-driven biopsies obtained from high-risk gastric cancer clinics in low resource settings.We discovered and...
Vitalina M Komashko et al.
Epigenetics, 5(3), 229-240 (2010-03-23)
Methylation of DNA in combination with histone modifications establishes an epigenetic code that ensures the proper control of gene expression. Although DNA methyltransferases have been shown to interact with histone methyltransferases such as EZH2 (which methylates histone H3 on lysine...
Claudia Pisanu et al.
Pharmacogenomics, 19(2), 129-143 (2017-12-05)
Mood stabilizers are the cornerstone in treatment of mood disorders, but their use is characterized by high interindividual variability. This feature has stimulated intensive research to identify predictive biomarkers of response and disentangle the molecular bases of their clinical efficacy....
INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program
Pirini F, et al.
Molecular Medicine Reports, 17(1), 1699-1709 (2018)
Martina Chiacchiarini et al.
Pharmacology & therapeutics, 219, 107708-107708 (2020-10-23)
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor comprising hereditary or sporadic form with frequent mutations in the rearranged during transfection (RET) or RAS genes. Diagnosis is based on the presence of thyroid tumor mass with altered levels of...
Kazuhisa Nakano et al.
Journal of immunology (Baltimore, Md. : 1950), 190(3), 1297-1303 (2013-01-02)
Rheumatoid arthritis (RA) is a chronic inflammatory disease in which fibroblast-like synoviocytes (FLS) exhibit an aggressive phenotype. Although the mechanisms responsible are not well defined, epigenetic determinants such as DNA methylation might contribute. DNA methyltransferases (DNMTs) are critical enzymes that...
Céline Jousse et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(9), 3271-3278 (2011-06-15)
Transient environmental influences, such as perinatal nutritional stress, may induce deleterious metabolic symptoms that last for the entire life of individuals, implying that epigenetic modifications play an important role in this process. We have investigated, in mice, the consequences of...
Global DNA methylation profile in medullary thyroid cancer patients
Ceolin L, et al.
Experimental and Molecular Pathology (2018)
Isabela Tatiana Sales de Arruda et al.
Genetics and molecular biology, 36(4), 490-493 (2014-01-05)
DNA methylation is mediated by DNA methyltransferases (DNMTs) that add a methyl group to the 5'-carbon of cytosine. The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the rate-limiting step of the cycle involving the methyl...
Simone Altmann et al.
Epigenetics, 7(3), 239-252 (2012-03-21)
Recent evidence indicates that maternal nutrition during pregnancy influences gene expression in offspring through epigenetic alterations. In the present study we evaluated the effect of protein excess and deficiency during porcine pregnancy on offspring hepatic and skeletal muscular expression patterns...
Pooja Sagvekar et al.
The Journal of clinical endocrinology and metabolism, 102(4), 1396-1405 (2017-03-23)
Altered global DNA methylation is indicative of epigenomic instability concerning chronic diseases. Investigating its incidence and association with polycystic ovary syndrome (PCOS) is essential to understand the etiopathogenesis of this disorder. We assessed global DNA methylation differences in peripheral blood...
Felicitas Thol et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(18), 2499-2506 (2011-05-18)
To study the incidence and prognostic impact of mutations in Additional sex comb-like 1 (ASXL1) in a large cohort of patients with myelodysplastic syndrome (MDS). Overall, 193 patients with MDS and 65 healthy volunteers were examined for ASXL1 mutations by...
Ana Torroglosa et al.
Genetics in medicine : official journal of the American College of Medical Genetics, 16(9), 703-710 (2014-03-01)
Hirschsprung disease (OMIM 142623) is a neurocristopathy attributed to a failure of cell proliferation or migration and/or failure of the enteric precursors along the gut to differentiate during embryonic development. Although some genes involved in this pathology are well characterized...
Mounira Krifa et al.
Journal of experimental & clinical cancer research : CR, 32, 30-30 (2013-05-22)
Several reports have described the potential effects of natural compounds as anti-cancer agents in vitro as well as in vivo. The aim of this study was to evaluate the anti-cancer effect of Limoniastrum guyonianum aqueous gall extract (G extract) and...
Maiko Suzuki et al.
Molecular medicine reports, 1(4), 465-471 (2008-07-01)
Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis in oral squamous cell carcinoma (OSCC). In this study, we used the novel DNA methyltransferase inhibitor zebularine (Zeb) to investigate epigenetic influences on the secretion of VEGF-A in the...
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