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Gabriel E Bertolesi et al.
Pigment cell & melanoma research, 28(5), 559-571 (2015-06-23)
How skin colour adjusts to circadian light/dark cycles is poorly understood. Melanopsin (Opn4) is expressed in melanophores, where in vitro studies suggest it regulates skin pigmentation through a 'primary colour response' in which light photosensitivity is translated directly into pigment
Yang Cheng et al.
Microbes and infection, 16(5), 419-428 (2014-02-25)
The newly identified GPI-anchored Plasmodium vivax merozoite surface protein 1 paralog (MSP1P) has a highly antigenic C-terminus that binds erythrocytes. To characterize the antigenicity and immunogenicity of two regions (PvMSP1P-19 and -33) of the highly conserved C-terminus of MSP1P relative
Junhyoung Ahn et al.
Biosensors & bioelectronics, 71, 115-120 (2015-04-22)
The aim of the study was to develop a simple and rapid immunoassay using fluorescent microbeads and enzyme-substrate reactions to measure alpha-fetal protein (AFP) concentrations. We demonstrated the functionality of the fluorescent immunosensor using antibody-conjugated fluorescent latex beads (AB-FLBs) and
Konstanze Scheller et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(9), 1601-1601 (2013-05-07)
The pathogenesis and prevention of cleft lip and palate (CL/P) have been studied mainly in clinical and animal experiments. A prophylactic poly-B-vitamin substitution during the first months of pregnancy has provided the most encouraging results for the prevention of CL/P
Li Zhang et al.
PloS one, 10(2), e112716-e112716 (2015-02-19)
Apert syndrome (AS) is a type of autosomal dominant disease characterized by premature fusion of the cranial sutures, severe syndactyly, and other abnormalities in internal organs. Approximately 70% of AS cases are caused by a single mutation, S252W, in fibroblast
Akif Hakan Kurt et al.
Oncology letters, 10(5), 3177-3182 (2016-01-02)
Estrogen mediates fast signal responses or transcriptional events via G protein-coupled estrogen receptor 1 (GPER1). However, there is no data on the effect of GPER1 on lung cancer cell proliferation and apoptosis. The present study aimed to analyze the anticancer
Xiaomin Liu et al.
International journal of molecular medicine, 45(2), 519-531 (2019-12-04)
Ginsenoside Rb3 (G‑Rb3) has been demonstrated to alleviate myocardial ischemia reperfusion injury (MIRI); however, it is difficult to separate G‑Rb2 from its isomer G‑Rb3. The current study aimed to compare the cardioprotective effects of G‑Rb3 and the concomitant use of
Li Huang et al.
Autophagy, 15(3), 407-422 (2018-09-14)
Glucose produced from photosynthesis is a key nutrient signal regulating root meristem activity in plants; however, the underlying mechanisms remain poorly understood. Here, we show that, by modulating reactive oxygen species (ROS) levels, the conserved macroautophagy/autophagy degradation pathway contributes to
Yoshimitsu Kuwabara et al.
The Journal of endocrinology, 224(1), 49-59 (2014-10-30)
Osteopontin (OPN), a secreted glycoprotein, has multiple physiological functions. This study investigated the regulation and roles of OPN in the mouse ovary during the periovulatory stages. Immature female mice were treated with pregnant mare serum gonadotropin (PMSG) and human chorionic
Valentina Cianfanelli et al.
Nature cell biology, 17(1), 20-30 (2014-12-02)
Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-dependent cell processes are largely unknown. Here we show that the
Valentina Vacca et al.
Toxins, 12(8) (2020-08-06)
Botulinum neurotoxin type A (BoNT/A) is a major therapeutic agent that has been proven to be a successful treatment for different neurological disorders, with emerging novel therapeutic indications each year. BoNT/A exerts its action by blocking SNARE complex formation and
Jin Liu et al.
Bone, 78, 203-211 (2015-05-12)
Hypophosphatasia (HPP) is an inborn-error-of-metabolism disorder characterized by deficient bone and tooth mineralization due to loss-of function mutations in the gene (Alpl) encoding tissue-nonspecific alkaline phosphatase (TNAP). Alpl(-/-) mice exhibit many characteristics seen in infantile HPP including long bone and
Claudio Laquatra et al.
Cell death & disease, 12(5), 434-434 (2021-05-03)
The mitochondrial paralog of the Hsp90 chaperone family TRAP1 is often induced in tumors, but the mechanisms controlling its expression, as well as its physiological functions remain poorly understood. Here, we find that TRAP1 is highly expressed in the early
Osamu Sakai et al.
Investigative ophthalmology & visual science, 56(1), 538-543 (2015-01-13)
The purpose of the present study was to investigate the role of glutathione peroxidase 4 (GPx4) in conjunctival epithelial cells. An immortalized human conjunctival epithelial cell line was used. Cells were transfected with catalase, GPx1, GPx4, SOD1, SOD2, or control
Drought- and salt-tolerant plants result from overexpression of the AVP1 H+-pump.
Gaxiola RA et al.
Proceedings of the National Academy of Sciences of the USA, 98, 11444-11444 (2001)
Hubert Sytykiewicz et al.
PloS one, 9(11), e111863-e111863 (2014-11-05)
The purpose of this report was to evaluate the expression patterns of selected glutathione transferase genes (gst1, gst18, gst23 and gst24) in the tissues of two maize (Zea mays L.) varieties (relatively resistant Ambrozja and susceptible Tasty Sweet) that were
Takashi Kasukabe et al.
International journal of oncology, 46(2), 841-848 (2014-11-19)
Arsenic trioxide (ATO) is an approved treatment for acute promyelocytic leukemia (APL). It has also shown potential for treatment of multiple myeloma and various solid tumors including breast cancer. The requirement of high, toxic concentrations for the induction of apoptosis
Kayoko Katayama et al.
Nihon eiseigaku zasshi. Japanese journal of hygiene, 66(3), 573-581 (2011-06-28)
In this study, we investigated the relationships of neutrophil functions with lifestyle factors (namely, subjective stress, exercise habits, smoking habits, alcohol-drinking habits, and self-perceived status health) and health behavior in the Chinese urban elderly. We performed a health survey of
John P Sundberg et al.
Experimental and molecular pathology, 97(3), 525-528 (2014-12-03)
Alopecia areata (AA), a cell mediated autoimmune disease, is the second most common form of hair loss in humans. While the autoimmune disease is responsible for the underlying pathogenesis, the alopecia phenotype is ultimately due to hair shaft fragility and
K J Taylor et al.
Parasite immunology, 37(1), 23-31 (2014-11-08)
Translationally controlled tumour protein (TCTP) may play an important role in the establishment or maintenance of parasitemia in a malarial infection. In this study, the potential of TCTP as a malaria vaccine was investigated in two trials. In the initial
Mathieu Quesnel-Vallières et al.
Genes & development, 29(7), 746-759 (2015-04-04)
Alternative splicing (AS) generates vast transcriptomic complexity in the vertebrate nervous system. However, the extent to which trans-acting splicing regulators and their target AS regulatory networks contribute to nervous system development is not well understood. To address these questions, we
J Gu et al.
European review for medical and pharmacological sciences, 19(13), 2354-2358 (2015-07-28)
The correlation of the embryo matrix metalloproteinase-9 (MMP-9) secretion, embryonic development and clinical pregnancy was investigated. The embryo culture from in vitro fertilization-embryo transfer (IVF-ET) patients were collected in the Xuzhou Central Hospital from January 2013 to September 2014. At
Xin-Wei Liu et al.
Neuroscience letters, 595, 74-80 (2015-04-14)
Melatonin plays a neuroprotective role in different CNS injuries. However, the molecular mechanisms underlying neuroprotection by melatonin are not well understood. Here, we studied the effects of melatonin in hypoxia-induced N2a cells and our results demonstrated that melatonin not only
Marjolaine A Pelissier-Rota et al.
The international journal of biochemistry & cell biology, 65, 239-256 (2015-06-24)
Nicotine, one of the active components in cigarette smoke, has been described to contribute to the protective effect of smoking in ulcerative colitis (UC) patients. Furthermore, the nicotinic acetylcholine receptor α7 subunit (α7nAChR) expressed on immune cells, is an essential
Masatoshi Komatsu et al.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 20(4), 708-716 (2015-05-20)
Osteoarthritis (OA) and rheumatoid arthritis (RA) are widespread disabling joint disorders that are considered to be polygenic in nature. This study investigated the spatial expression patterns of all six known human CCN genes using end-stage OA and RA joint samples.
Jian Wu et al.
Cell research, 25(5), 621-633 (2015-04-25)
Programmed cell death (PCD) is of fundamental importance to development and defense in animals and plants. In plants, a well-recognized form of PCD is hypersensitive response (HR) triggered by pathogens, which involves the generation of reactive oxygen species (ROS) and
Ileana Soto et al.
PLoS biology, 13(10), e1002279-e1002279 (2015-10-30)
Aging is the major risk factor for neurodegenerative diseases such as Alzheimer's disease, but little is known about the processes that lead to age-related decline of brain structures and function. Here we use RNA-seq in combination with high resolution histological
A Bolekova et al.
European journal of histochemistry : EJH, 55(3), e23-e23 (2011-11-11)
The purpose of this study was to analyze the nicotinamide adenine dinucleotide phosphate - diaphorase (NADPH-d) activity in the rat jejunum after a mesenteric ischemia/reperfusion injury. Nitric oxide, synthetised from L-arginine by the enzyme nitric oxide synthase, is a nonadrenergic
Anne Czechanski et al.
Developmental biology, 402(2), 253-262 (2015-04-01)
Genome integrity in the developing germ line is strictly required for fecundity. In proliferating somatic cells and in germ cells, there are mitotic checkpoint mechanisms that ensure accurate chromosome segregation and euploidy. There is growing evidence of mitotic cell cycle
Sheng Su et al.
Investigative ophthalmology & visual science, 55(12), 7848-7861 (2014-11-20)
To identify differential changes in proteins and metabolites underlying "fast" type 1 (T1DC) and "slow" type 2 (T2DC) diabetic cataract (DC) formation in rat. Rat models of types 1 and 2 diabetes consisted of streptozotocin injection without and with high-fat
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