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Robert Dalton et al.
International journal of molecular sciences, 22(3) (2021-01-31)
Dendritic cells (DCs) are professional antigen presenting cells with a great capacity for cross-presentation of exogenous antigens from which robust anti-tumor immune responses ensue. However, this function is not always available and requires DCs to first be primed to induce
Ashlee J Tipton et al.
American journal of physiology. Renal physiology, 313(4), F847-F853 (2017-07-07)
Female spontaneously hypertensive rats (SHR) have more renal regulatory T cells (Tregs) than males, and greater levels of Tregs in female SHR are dependent on blood pressure (BP). However, the molecular mechanism responsible for greater Tregs in female SHR is
Mattias K Andersson et al.
Oncogenesis, 9(1), 5-5 (2020-02-01)
Adenoid cystic carcinoma (ACC) is a rare cancer that preferentially occurs in the head and neck, breast, as well as in other sites. It is an aggressive cancer with high rates of recurrence and distant metastasis. Patients with advanced disease
Hyun-Jung Kim et al.
Cellular and molecular life sciences : CMLS, 79(3), 155-155 (2022-02-27)
Cellular senescence is closely related to tissue aging including bone. Bone homeostasis is maintained by the tight balance between bone-forming osteoblasts and bone-resorbing osteoclasts, but it undergoes deregulation with age, causing age-associated osteoporosis, a main cause of which is osteoblast
Manuel Kaulich et al.
Scientific reports, 11(1), 14736-14736 (2021-07-21)
During early G1 phase, Rb is exclusively mono-phosphorylated by cyclin D:Cdk4/6, generating 14 different isoforms with specific binding patterns to E2Fs and other cellular protein targets. While mono-phosphorylated Rb is dispensable for early G1 phase progression, interfering with cyclin D:Cdk4/6
Etienne Delangre et al.
Cell death & disease, 12(12), 1136-1136 (2021-12-09)
Glucocorticoids (GCs) are widely prescribed for their anti-inflammatory and immunosuppressive properties as a treatment for a variety of diseases. The use of GCs is associated with important side effects, including diabetogenic effects. However, the underlying mechanisms of GC-mediated diabetogenic effects
Irene Zorzan et al.
Nature communications, 11(1), 2364-2364 (2020-05-14)
Human pluripotent stem cells (hPSCs) have the capacity to give rise to all differentiated cells of the adult. TGF-beta is used routinely for expansion of conventional hPSCs as flat epithelial colonies expressing the transcription factors POU5F1/OCT4, NANOG, SOX2. Here we
Martin Khan et al.
Head & neck, 42(4), 625-635 (2020-01-11)
MET has emerged as target in head and neck squamous cell carcinoma (HNSCC). However, clinical data on MET inhibition in HNSCC are limited. HNSCC biopsies and cell lines were tested for MET activity. The response of cell lines to BAY-853474
Åsa M E Winther et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(44), 14756-14770 (2015-11-06)
Many endocytic proteins accumulate in the reserve pool of synaptic vesicles (SVs) in synapses and relocalize to the endocytic periactive zone during neurotransmitter release. Currently little is known about their functions outside the periactive zone. Here we show that in
Shihyin Tsai et al.
The Journal of clinical investigation, 125(8), 2952-2964 (2015-06-30)
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) is a key downstream effector of mTOR complex 1 (mTORC1) that represses cap-dependent mRNA translation initiation by sequestering the translation initiation factor eIF4E. Reduced mTORC1 signaling is associated with life span extension
Małgorzata Maksymowicz et al.
Cell communication and signaling : CCS, 18(1), 176-176 (2020-11-06)
Lymphotoxin β receptor (LTβR) is a member of tumor necrosis factor receptor (TNFR) superfamily which regulates the immune response. At the cellular level, upon ligand binding, the receptor activates the pro-inflammatory NF-κB and AP-1 pathways. Yet, the intracellular distribution of
Christian W Johnson et al.
Cell reports, 28(6), 1538-1550 (2019-08-08)
Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas-driven colorectal cancers, while observed only rarely in HRas or
Yipeng Sui et al.
Environmental health perspectives, 129(12), 127001-127001 (2021-12-02)
Exposure to plastic-associated endocrine disrupting chemicals (EDCs) has been associated with an increased risk of cardiovascular disease (CVD) in humans. However, the underlying mechanisms for this association are unclear. Many EDCs have been shown to function as ligands of the
Mirja Tamara Prentzell et al.
Cell, 184(3), 655-674 (2021-01-27)
Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components of stress granules (SGs). We report that G3BPs reside at the cytoplasmic surface of lysosomes. They act in a non-redundant manner to anchor
Grigory Ryzhakov et al.
Nature communications, 12(1), 6702-6702 (2021-11-20)
Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, and has a key pathogenic function in gut inflammation, but how IRF5 is modulated is still unclear. Having performed a kinase inhibitor library screening in macrophages, here we
Emanuele Gabellieri et al.
European journal of medicinal chemistry, 204, 112615-112615 (2020-08-11)
The compound screening was initiated with a direct staining assay to identify compounds binding to Tau aggregates and not Abeta plaques using human brain sections derived from late stage Alzheimer's disease donors. The binding of Tau aggregate selective compounds was
Anna Preisner et al.
Acta neuropathologica, 130(2), 247-261 (2015-05-07)
Multiple sclerosis is the most frequent demyelinating disease in the CNS that is characterized by inflammatory demyelinating lesions and axonal loss, the morphological correlate of permanent clinical disability. Remyelination does occur, but is limited especially in chronic disease stages. Despite
Darren M Gordon et al.
Archives of biochemistry and biophysics, 672, 108072-108072 (2019-08-20)
Obesity is the predominant cause of non-alcoholic fatty liver disease (NAFLD), which is associated with insulin resistance and diabetes. NAFLD includes a spectrum of pathologies that starts with simple steatosis, which can progress to non-alcoholic steatohepatitis (NASH) with the commission
Cellular proteostasis decline in human senescence.
Sabath, et al.
Proceedings of the National Academy of Sciences of the USA, 117, 31902-31913 (2021)
Vandana Rai et al.
The Journal of biological chemistry, 292(8), 3099-3111 (2017-01-06)
Non-muscle myosin II (NMII) is a conserved force-producing cytoskeletal enzyme with important but poorly understood roles in cell migration. To investigate myosin heavy chain (MHC) phosphorylation roles in 3D migration, we expressed GFP-tagged NMIIA wild-type or mutant constructs in cells
Shashank Rai et al.
Autophagy, 15(4), 599-612 (2018-11-08)
Macroautophagy/autophagy delivers damaged proteins and organelles to lysosomes for degradation, and plays important roles in maintaining tissue homeostasis by reducing tissue damage. The translocation of LC3 to the limiting membrane of the phagophore, the precursor to the autophagosome, during autophagy
Jacob R Mann et al.
Neuron, 102(2), 321-338 (2019-03-04)
TDP-43 proteinopathy is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within degenerating regions of patient postmortem tissue. The mechanism by which TDP-43 aggregates has remained elusive due to technological limitations, which
Wondossen Sime et al.
Cell death & disease, 9(5), 458-458 (2018-04-25)
BRCA1-associated protein 1 (BAP1) is a nuclear deubiquitinating enzyme that is associated with multiprotein complexes that regulate key cellular pathways, including cell cycle, cellular differentiation, cell death, and the DNA damage response. In this study, we found that the reduced
Matthew Cannon et al.
Journal of clinical medicine, 9(7) (2020-07-28)
Sickle-cell disease (SCD) is a debilitating hematological disorder with very few approved treatment options. Therapeutic reactivation of fetal hemoglobin (HbF) is one of the most pursued methods for ameliorating the systemic manifestations of SCD. Despite this, very few pharmacological agents
P P Mahesh et al.
Scientific reports, 6, 21526-21526 (2016-02-16)
Mycobacterium tuberculosis persists primarily in macrophages after infection and manipulates the host defence pathways in its favour. 2D gel electrophoresis results showed that vimentin, an intermediate filament protein, is downregulated in macrophages infected with live Mycobacterium tuberculosis H37Rv when compared
Prabin Dhangada Majhi et al.
Environmental health perspectives, 128(1), 17002-17002 (2020-01-16)
Endocrine-disrupting chemicals have been shown to have broad effects on development, but their mutagenic actions that can lead to cancer have been less clearly demonstrated. Physiological levels of estrogen have been shown to stimulate DNA damage in breast epithelial cells
Ronit Shapira et al.
Aging, 13(17), 20935-20961 (2021-09-10)
Vascular dysfunction is entwined with aging and in the pathogenesis of Alzheimer's disease (AD) and contributes to reduced cerebral blood flow (CBF) and consequently, hypoxia. Hyperbaric oxygen therapy (HBOT) is in clinical use for a wide range of medical conditions.
Andrea Leonardi et al.
Epigenetics, 15(10), 1121-1138 (2020-04-19)
The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins. Using Alkbh8 deficient (Alkbh8def) mice, we have investigated the importance of
Jose V Moyano et al.
Molecular biology of the cell, 21(21), 3654-3668 (2010-09-17)
Laminin (LM)-332 is an extracellular matrix protein that plays a structural role in normal tissues and is also important in facilitating recovery of epithelia from injury. We have shown that expression of LM-332 is up-regulated during renal epithelial regeneration after
Hila Ben-Moshe et al.
Journal of molecular neuroscience : MN, 70(1), 32-44 (2019-09-07)
The ɛ4 allele of apolipoprotein E (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease. ApoE4 is also associated with poor recovery and functional outcome following traumatic brain injury. This study examined the effects of the apoE genotype
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