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Victoria-Elisabeth Gruber et al.
Neuropathology and applied neurobiology, 47(6), 812-825 (2021-06-27)
We aim to evaluate if the myelin pathology observed in epilepsy-associated focal cortical dysplasia type 2B (FCD2B) and-histologically indistinguishable-cortical tubers of tuberous sclerosis complex (TSC) is primarily related to the underlying malformation or constitutes a secondary phenomenon due to the
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Xi Chen et al.
Molecular neurobiology, 56(4), 3053-3067 (2018-08-09)
Radix Astragali (AR) is a commonly used medicinal herb for post-stroke disability in Traditional Chinese Medicine but its active compounds for promoting neurogenic effects are largely unknown. In the present study, we tested the hypothesis that Astragaloside VI could be
Xianzhu Zhang et al.
Biomaterials, 232, 119724-119724 (2020-01-10)
Changes in the stiffness of chondrocyte extracellular matrix (ECM) are involved in the pathological progression of osteoarthritis (OA). However, the downstream responses of cartilage ECM stiffness are still unclear. YAP (Yes-associated protein) has been extensively studied as a mechanotransducer, we
Kristine C Olson et al.
Cancer biology & therapy, 18(5), 290-303 (2016-10-08)
Large granular lymphocyte leukemia (LGLL) is a rare incurable chronic disease typically characterized by clonal expansion of CD3+ cytotoxic T-cells. Two signal transducer and activator of transcription factors, STAT1 and STAT3, are constitutively active in T-LGLL. Disruption of this activation
Bethany N Radford et al.
Pediatric research, 87(3), 450-455 (2019-06-12)
Intrauterine growth restriction (IUGR) is a pregnancy condition where fetal growth is reduced, and offspring from IUGR pregnancies are at increased risk for type II diabetes as adults. The liver is susceptible to fetal undernutrition experienced by IUGR infants and
Bo-Ruei Chen et al.
The Journal of cell biology, 218(7), 2113-2123 (2019-05-28)
XRCC4-like factor (XLF) is a non-homologous end joining (NHEJ) DNA double strand break repair protein. However, XLF deficiency leads to phenotypes in mice and humans that are not necessarily consistent with an isolated defect in NHEJ. Here we show that
Jessica A Jiménez et al.
Molecular autism, 11(1), 74-74 (2020-10-08)
Chromodomain helicase DNA-binding protein 8 (Chd8) is a high-confidence risk gene for autism spectrum disorder (ASD). However, how Chd8 haploinsufficiency impairs gene expression in the brain and impacts behavior at different stages of life is unknown. We generated a mutant
Josiah V Dungwa et al.
BMC cancer, 11, 390-390 (2011-09-14)
Overexpression of carbonic anhydrase (CA IX) is associated with poor survival in several adult-type cancers but its expression is undocumented in Wilms tumour (WT), the most common tumour of the paediatric kidney. CA9 expression was measured using polymerase chain reaction
Zachery R Belak et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 98(2), 178-190 (2019-09-04)
We previously demonstrated that genome reorganization, through chromosome territory repositioning, occurs concurrently with significant changes in gene expression in normal primary human fibroblasts treated with the drug rapamycin, or stimulated into quiescence. Although these events occurred concomitantly, it is unclear
Elizabeth A Bowling et al.
Cell, 184(2), 384-403 (2021-01-16)
Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs selectively kill cancers remain largely unknown. Herein, we discover that mis-spliced RNA itself is a molecular trigger for
Upayan Patra et al.
Oxidative medicine and cellular longevity, 2020, 7289120-7289120 (2020-04-24)
Eukaryotic cells adopt highly tuned stress response physiology under threats of exogenous stressors including viruses to maintain cellular homeostasis. Not surprisingly, avoidance of cellular stress response pathways is an essential facet of virus-induced obligatory host reprogramming to invoke a cellular
Madhukar B Kolli et al.
Biomaterials, 35(37), 9951-9962 (2014-09-17)
Cerium oxide (CeO2) nanoparticles have been posited to exhibit potent anti-oxidant activity which may allow for the use of these materials in biomedical applications. Herein, we investigate whether CeO2 nanoparticle administration can diminish right ventricular (RV) hypertrophy following four weeks
Wondossen Sime et al.
Cell death & disease, 9(5), 458-458 (2018-04-25)
BRCA1-associated protein 1 (BAP1) is a nuclear deubiquitinating enzyme that is associated with multiprotein complexes that regulate key cellular pathways, including cell cycle, cellular differentiation, cell death, and the DNA damage response. In this study, we found that the reduced
Helle Samdal et al.
The FEBS journal, 285(13), 2446-2467 (2018-05-04)
The omega-3 fatty acid docosahexaenoic acid (DHA) is known as an anticancer agent. Colorectal cancer (CRC) cells exhibit different sensitivity toward DHA, but the mechanisms involved are still unclear. Gene expression profiling of 10 CRC cell lines demonstrated a correlation
Hyun-Jung Kim et al.
Oncotarget, 8(4), 6608-6622 (2016-12-31)
Autophagy is the process of lysosome-mediated degradation and recycling that functions as an adaptive survival mechanism during anti-cancer therapy. Aberrant activation of the phosphoinositide-3-kinase (PI3K) pathway frequently occurs in solid tumors, including cervical cancer. However, single-agent PI3K inhibitors show modest
Sarah P Short et al.
Molecular cancer research : MCR, 17(4), 882-894 (2019-01-19)
Serine threonine kinase 17A (STK17A) is a ubiquitously expressed kinase originally identified as a regulator of apoptosis; however, whether it functionally contributes to colorectal cancer has not been established. Here, we have analyzed STK17A in colorectal cancer and demonstrated decreased
Jordan T Schmidt et al.
Neurotoxicology, 63, 1-12 (2017-08-29)
Mitochondria are sensitive targets of environmental chemicals. Dieldrin (DLD) is an organochlorine pesticide that remains a human health concern due to high lipid bioaccumulation, and it has been epidemiologically associated to an increased risk for Parkinson's disease (PD). As mitochondrial
Haider Inam et al.
iScience, 24(11), 103343-103343 (2021-11-27)
Genomic data can facilitate personalized treatment decisions by enabling therapeutic hypotheses in individual patients. Mutual exclusivity has been an empirically useful signal for identifying activating mutations that respond to single agent targeted therapies. However, a low mutation frequency can underpower
Masayuki Kaneko et al.
Journal of neuroscience research, 93(2), 370-379 (2014-10-07)
The loss of homeostasis of essential metals is associated with various diseases, including neurodegenerative diseases. Previous studies have shown that the levels of zinc (Zn) are significantly higher in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis (ALS). Zn
Nicholas J Eustace et al.
International journal of oncology, 54(6), 2039-2053 (2019-04-04)
Glioblastoma harbors frequent alterations in receptor tyrosine kinases, phosphatidylinositol‑3 kinase (PI3K) and phosphatase and tensin homolog (PTEN) that dysregulate phospholipid signaling driven tumor proliferation and therapeutic resistance. Myristoylated alanine‑rich C‑kinase substrate (MARCKS) is a 32 kDa intrinsically unstructured protein containing a polybasic (+13)
Grigory Ryzhakov et al.
Nature communications, 12(1), 6702-6702 (2021-11-20)
Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, and has a key pathogenic function in gut inflammation, but how IRF5 is modulated is still unclear. Having performed a kinase inhibitor library screening in macrophages, here we
Ji Zhang et al.
Scientific reports, 11(1), 2118-2118 (2021-01-24)
Lung fibrosis, or the scarring of the lung, is a devastating disease with huge unmet medical need. There are limited treatment options and its prognosis is worse than most types of cancer. We previously discovered that MK-0429 is an equipotent
Karen K L Chan et al.
Cancer cell international, 18, 65-65 (2018-05-11)
Ovarian cancer is the most lethal gynaecological malignancy. Chemotherapy is the main stay of treatment for metastatic disease, with modest response rates but significant side effects. Therefore, there is a need for alternative therapies that can control the disease while
David Y Barefield et al.
Journal of molecular and cellular cardiology, 129, 236-246 (2019-03-14)
Cardiac myosin binding protein-C (cMyBP-C) phosphorylation is essential for normal heart function and protects the heart from ischemia-reperfusion (I/R) injury. It is known that protein kinase-A (PKA)-mediated phosphorylation of cMyBP-C prevents I/R-dependent proteolysis, whereas dephosphorylation of cMyBP-C at PKA sites
Yulia Dzhashiashvili et al.
Neurobiology of disease, 127, 527-544 (2019-03-30)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by motor neuron death in the brain and spinal cord. Mutations in the Cu/Zn superoxide dismutase (SOD1) gene account for ~20% of all familial ALS forms, corresponding to 1%-2% of
Leivi Portugal et al.
Insect biochemistry and molecular biology, 80, 21-31 (2016-11-22)
Bacillus thuringiensis (Bt) bacteria produce Cry toxins that are able to kill insect pests. Different models explaining the mode of action of these toxins have been proposed. The pore formation model proposes that the toxin creates pores in the membrane
Charlie Y Huang et al.
Scientific reports, 10(1), 2865-2865 (2020-02-20)
Antibiotic persistence is a transient phenotypic state during which a bacterium can withstand otherwise lethal antibiotic exposure or environmental stresses. In Escherichia coli, persistence is promoted by the HipBA toxin-antitoxin system. The HipA toxin functions as a serine/threonine kinase that
Danielle Andrzejewski et al.
Endocrinology, 156(7), 2440-2450 (2015-05-12)
TGFβ superfamily ligands, receptors, and second messengers, including activins A and B, have been identified in pancreatic islets and proposed to have important roles regulating development, proliferation, and function. We previously demonstrated that Fstl3 (an antagonist of activin activity) null
Douglas W Van Pelt et al.
American journal of physiology. Endocrinology and metabolism, 313(4), E429-E439 (2017-07-07)
Although the rate of fatty acid release from adipose tissue into the systemic circulation is very high in most obese adults, some obese adults maintain relatively low rates of fatty acid release, which helps protect them against the development of
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