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phr1007

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Hans Christian Helms et al.
The AAPS journal, 16(5), 1046-1055 (2014-06-18)
Efflux transporters of the ATP-binding cassette superfamily including breast cancer resistance protein (Bcrp/Abcg2), P-glycoprotein (P-gp/Abcb1) and multidrug resistance-associated proteins (Mrp's/Abcc's) are expressed in the blood-brain barrier (BBB). The aim of this study was to investigate if a bovine endothelial/rat astrocyte
Željka Vanić et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 443-454 (2014-06-15)
The purpose of this study was to develop a novel drug delivery system for challenging drugs with potential for scale-up manufacturing and controlled release of incorporated drug. Pre-liposomes powder containing metronidazole, lecithin and mannitol, prepared by spray-drying, was mixed with
Halinder S Mangat et al.
Journal of neurosurgery, 122(1), 202-210 (2014-11-08)
Increased intracranial pressure (ICP) in patients with traumatic brain injury (TBI) is associated with a higher mortality rate and poor outcome. Mannitol and hypertonic saline (HTS) have both been used to treat high ICP, but it is unclear which one
J-H La et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(12), 1730-1742 (2014-10-14)
A low-level inflammation has been hypothesized to mediate visceral hypersensitivity in functional bowel disorders that persist after or even in the absence of gut inflammation. We aimed to test the efficacy of a steroidal anti-inflammatory treatment, and identify local inflammatory
Soyoung Kwak et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(9), 779-787 (2014-06-14)
Fisetin, an active compound isolated from flowering plants in the family Fabaceae, was reported to have antiviral, neuroprotective, and anti-inflammatory effects. Vascular inflammatory processes have been suggested to play key roles in the initiation and progression of atherosclerosis, a major
R Bergeron et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(11), 774-781 (2014-07-02)
Studies on normoglycemic ovariectomized Sprague-Dawley rats have provided insights about the effects of estrogen deficiency on insulin resistance in lean individuals. It is not completely clear if subjects with pre-established obesity and insulin resistance are at greater risk of developing
Oluwatomide Adeoye et al.
Pharmaceutical development and technology, 19(8), 901-910 (2013-10-05)
Novel multifunctional excipients were prepared by coprocessing tapioca starch with mannitol using two methods viz; co-grinding and co-fusion. The flow, packing and compaction properties of the native and novel excipients were evaluated by using density, Hausner's ratio, angle of repose
Soraya Cherifi et al.
Annals of clinical microbiology and antimicrobials, 13, 20-20 (2014-06-06)
Staphylococcus epidermidis is a pathogen that is frequently encountered in the hospital environment. Healthcare workers (HCWs) can serve as a reservoir for the transmission of S. epidermidis to patients. The aim of this study was to compare and identify differences
A Kiyoshima et al.
Journal of chromatography. B, Biomedical sciences and applications, 758(1), 103-108 (2001-08-03)
A simple, reliable and sensitive gas chromatographic-mass spectrometric method was devised to determine the level of mannitol in various human brain tissues obtained at autopsy. Mannitol was extracted with 10% trichloroacetic acid solution which effectively precipitated brain tissues. The supernatant
J-M Serot et al.
Journal of neurology, neurosurgery, and psychiatry, 76(11), 1585-1587 (2005-10-18)
Homocysteine may be involved in the pathogenesis of late onset Alzheimer's disease. It is implicated in the metabolism of several important pathways in the brain. Methylmalonic acid (MMA) is related to the metabolism of branched chained amino acids and fatty
L-B Li et al.
Transplantation proceedings, 45(2), 523-527 (2013-03-19)
Clinically, donor hearts cannot be preserved for >6 hours between explantation and recipient implantation. A better approach is needed to preserve donor hearts for a longer time. We tested whether low-flow perfusion (LFP) could satisfactorily preserve isolated rat hearts with
Etiology and management of exercise-associated hyponatremic encephalopathy (EAHE).
Ian R Rogers et al.
The American journal of emergency medicine, 32(7), 806-807 (2014-04-29)
Overcoming the undesirable properties of dry-powder inhalers with novel engineered mannitol particles.
Ali Nokhodchi et al.
Therapeutic delivery, 4(8), 879-882 (2013-08-08)
Jill R Blankenship et al.
Eukaryotic cell, 13(11), 1403-1410 (2014-09-14)
Septin proteins are conserved structural proteins that often demarcate regions of cell division. The essential nature of the septin ring, composed of several septin proteins, complicates investigation of the functions of the ring, although careful analysis in the model yeast
Marie-Claire Arrieta et al.
Inflammatory bowel diseases, 21(1), 8-18 (2014-12-18)
Increased intestinal permeability is found in noninflamed portions of the gut of inflammatory bowel disease patients and in their first-degree relatives, suggesting that it is not a consequence of inflammation. Additionally, increased small intestinal permeability precedes colonic disease in animal
F Dreher et al.
Skin pharmacology and applied skin physiology, 15 Suppl 1, 31-39 (2002-12-12)
Human skin models, such as EpiDerm and Episkin, are not easily mounted into static or dynamic diffusion cells that are commonly used to perform bioavailability studies with human skin ex vivo. For various reasons, such as fragility, small sample size
Anja Verhulst et al.
PloS one, 10(3), e0121861-e0121861 (2015-03-11)
Zoledronic acid, a highly potent nitrogen-containing bisphosphonate used for the treatment of pathological bone loss, is excreted unmetabolized via the kidney if not bound to the bone. In cancer patients receiving high doses of the compound renal excretion may be
Katherine P Morgan et al.
The Annals of pharmacotherapy, 46(2), 276-281 (2012-02-03)
To review the efficacy and safety of concomitant mannitol administration with cisplatin therapy to reduce the incidence of nephrotoxicity. A literature search was performed via MEDLINE, PubMed, and the Cochrane Library (1945-August 2011) using the terms mannitol, cisplatin, nephrotoxicity, and
Jian-ping Jia et al.
Chinese medical journal, 117(8), 1161-1164 (2004-09-14)
An important aspect of Alzheimer's disease (AD) is loss or impairment of cholinergic neurons. It is controversial whether there is a similar cholinergic impairment and cerebral deficit of acetylcholine (ACh) in the case of vascular dementia (VD). The purpose of
Ivana R Sequeira et al.
PloS one, 9(6), e99256-e99256 (2014-06-06)
Lactulose mannitol ratio tests are clinically useful for assessing disorders characterised by changes in gut permeability and for assessing mixing in the intestinal lumen. Variations between currently used test protocols preclude meaningful comparisons between studies. We determined the optimal sampling
Da Jung Kim et al.
Amino acids, 46(10), 2333-2343 (2014-06-24)
Infected wounds cause delay in wound closure and impose significantly negative effects on patient care and recovery. Antimicrobial peptides (AMPs) with antimicrobial and wound closure activities, along with little opportunity for the development of resistance, represent one of the promising
Jayant Nirmalkar et al.
Environmental science and pollution research international, 22(2), 1220-1231 (2014-08-19)
Organic molecular markers are important atmospheric constituents. Their formation and sources are important aspects of the study of urban and rural air quality. We collected PM10 aerosol samples from the Mahanadi Riverside Basin (MRB), a rural part of eastern central
M A Lovell et al.
Archives of neurology, 58(3), 392-396 (2001-03-20)
Markers of oxidative stress are increased in cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), although none of those reported are appropriate diagnostic markers because of the overlap between patients with AD and control subjects. To determine the ratio
Satu Kalliola et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 113(2), 166-172 (2014-06-03)
Airway hyperresponsiveness (AHR) is a hallmark of asthma but its assessment is usually restricted to older children who are capable of performing the maneuvers involved in spirometry. In younger children, a feasible option to perform the lung function measurement is
A double-edged sword.
Prescrire international, 23(148), 91-91 (2014-05-27)
Hannah Kenward et al.
Experimental brain research, 232(8), 2685-2697 (2014-05-06)
Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated administration of cisplatin.
A Manoharan et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(10), 1240-1245 (2014-06-11)
Although airway hyperresponsiveness (AHR) is a defining feature of asthma pathophysiology, bronchial challenge testing is not routinely used in primary care asthma management. The aim of this study was to evaluate the potential role of direct (methacholine) and indirect (mannitol)
Srinath Tamirisa et al.
Journal of experimental botany, 65(17), 4769-4781 (2014-05-29)
A potent cold and drought regulatory protein-encoding gene (CcCDR) was isolated from the subtractive cDNA library of pigeonpea plants subjected to drought stress. CcCDR was induced by different abiotic stress conditions in pigeonpea. Overexpression of CcCDR in Arabidopsis thaliana imparted
Noriaki Nagai et al.
Experimental eye research, 132, 115-123 (2015-01-31)
The goal in the search for successful therapies for glaucoma is the reduction of intraocular pressure (IOP), and the search for effective eye drops that reduce IOP is a high priority. We previously reported the potential of a 2-hydroxypropyl-β-cyclodextrin (HPβCD)
Leena Thung et al.
PloS one, 8(3), e58503-e58503 (2013-03-23)
The heterotrimeric G-protein complex in Arabidopsis thaliana consists of one α, one ß and three γ subunits. While two of the γ subunits, AGG1 and AGG2 have been shown to provide functional selectivity to the Gßγ dimer in Arabidopsis, it
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