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phr1533
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Enrique F Schisterman et al.
The Journal of clinical endocrinology and metabolism, 99(8), 2786-2794 (2014-05-23)
A role of lipids in human fecundity is hypothesized as cholesterol is the main substrate for steroid synthesis and has also been shown to affect the hormonal milieu and steroidogenesis in both men and women. The objective of the study
Charles P Najt et al.
Biochemistry, 53(45), 7051-7066 (2014-10-23)
Although perilipin 2 (Plin2) has been shown to bind lipids with high affinity, the Plin2 lipid binding site has yet to be defined. This is of interest since Plin2's affinity for lipids has been suggested to be important for lipid
Andrés Castellanos-Martín et al.
Genome biology, 16, 40-40 (2015-04-09)
An essential question in cancer is why individuals with the same disease have different clinical outcomes. Progress toward a more personalized medicine in cancer patients requires taking into account the underlying heterogeneity at different molecular levels. Here, we present a
Daniel E Platt et al.
Journal of thrombosis and thrombolysis, 39(1), 15-22 (2014-05-03)
A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk factor for coronary artery disease
Espen Rostrup et al.
European journal of preventive cardiology, 21(10), 1292-1299 (2013-03-22)
To better understand how prolonged electrical muscle stimulation can improve cardiorespiratory risk markers in obese subjects, we investigated the effect of prolonged combined thermal and electrical muscle stimulation (cTEMS) on peak oxygen consumption (VO2peak) and body composition with subsequent lipolytic
Hakan Uçar et al.
Scandinavian journal of clinical and laboratory investigation, 75(1), 7-12 (2014-09-03)
Gamma glutamyl transferase (GGT) is involved in the pathophysiologic process of coronary atherosclerosis. GGT activity plays a role in the catabolism of glutathione which is known as one of the major antioxidants. However, there is a lack of research on
Ana M Cardoso et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 347-356 (2014-12-17)
Gemini surfactants have been extensively used for in vitro gene delivery. Amino acid-derived gemini surfactants combine the special aggregation properties characteristic of the gemini surfactants with high biocompatibility and biodegradability. In this work, novel serine-derived gemini surfactants, differing in alkyl
Laskarina-Maria Korou et al.
Scientific reports, 4, 6806-6806 (2014-10-29)
Hyperlipidemia and stress are important factors affecting cardiovascular health in middle-aged individuals. We investigated the effects of N-acetylcysteine (NAC) and sesame oil on the lipidemic status, liver architecture and the hypothalamic-pituitary-adrenal (HPA) axis of middle-aged mice fed a cholesterol-enriched diet.
Philipp Rein et al.
Atherosclerosis, 240(1), 21-25 (2015-03-10)
People with chronic kidney disease frequently experience cardiovascular events. This study sought to investigate whether the presence of albuminuria displays a vascular risk equivalent to that in patients with prior myocardial infarction. Albuminuria was defined as a urinary albumin to
Muthukumaran Jayachandran et al.
Molecular and cellular biochemistry, 398(1-2), 39-53 (2014-09-15)
Hyperlipidemia is a major, modifiable risk factor for atherosclerosis and cardiovascular disease. In the present study, we have focused on the effect of different doses of geraniol (GOH) on the lipid profile and lipid metabolizing enzymes in atherogenic diet (AD)
K S Petersen et al.
Atherosclerosis, 238(2), 175-181 (2014-12-22)
To determine the dietary predictors of central blood pressure, augmentation index and pulse wave velocity (PWV) in subjects with type 1 and type 2 diabetes. Participants were diagnosed with type 1 or type 2 diabetes and had PWV and/or pulse
Fang Liu et al.
PloS one, 9(6), e97044-e97044 (2014-06-28)
ATP-binding cassette transporter G1 (ABCG1) is a transmembrane cholesterol transporter involved in macrophage sterol homeostasis, reverse cholesterol transport (RCT), and atherosclerosis. The role of ABCG1 in atherosclerosis remains controversial, especially in animal models. Our previous study showed that single nucleotide
S Maynard et al.
Acta physiologica (Oxford, England), 213(1), 156-170 (2014-04-08)
To examine associations of DNA damage, cardiovascular risk factors and physical performance with vitality, in middle-aged men. We also sought to elucidate underlying factors of physical performance by comparing physical performance parameters to DNA damage parameters and cardiovascular risk factors.
Eung Ju Kim et al.
PloS one, 9(6), e97841-e97841 (2014-06-06)
Although triglyceride accumulation in the liver causes non-alcoholic fatty liver disease (NAFLD), hypercholesterolemia is also a main cause of NAFLD as well as atherosclerosis. However, NAFLD and atherosclerosis have not been investigated simultaneously in animal models fed a high-cholesterol diet.
Shigehiko Karino et al.
Atherosclerosis, 238(2), 153-158 (2014-12-17)
Previous studies have reported an association between total and differential white blood cell (WBC) counts and incident coronary heart disease (CHD), but data from elderly populations are scarce. The purpose of this study was to examine the association between total
Hanna Johnsson et al.
Annals of the rheumatic diseases, 73(8), 1495-1499 (2013-05-30)
Raised total cholesterol (TC) and reduced high-density lipoprotein (HDL) cholesterol levels are established cardiovascular disease (CVD) risk factors. However, in autoimmune conditions the lipid-CVD association appears paradoxical, with inflammation as a potential confounding factor. We therefore sought to model the
Motohiro Sekiya et al.
Journal of lipid research, 55(10), 2082-2092 (2014-06-04)
An excess of cholesterol and/or oxysterols induces apoptosis in macrophages, contributing to the development of advanced atherosclerotic lesions. In foam cells, these sterols are stored in esterified forms, which are hydrolyzed by two enzymes: neutral cholesterol ester hydrolase 1 (Nceh1)
Evaluation of size-based distribution of drug and excipient in amphotericin B liposomal formulation.
Desiree Van Haute et al.
International journal of pharmaceutics, 569, 118603-118603 (2019-08-12)
Conventional quantitation of drug content in the liposome formulation involves the breakdown of bulk liposomes, which ignores details on the distribution of the active pharmaceutical ingredient (API) and excipients in liposomes of different sizes. The objective of this study is
Joseph Fomusi Ndisang et al.
Experimental biology and medicine (Maywood, N.J.), 240(1), 45-57 (2014-07-24)
Oxidative stress and inflammation are implicated in tissue remodeling, hypertrophy, and organ malfunction. Since heme-oxygenase (HO) is a cytoprotective enzyme with effects against oxidative stress and inflammation, we investigated the effects of upregulating HO with hemin on adipocyte hypertrophy, proteins
Caroline Damico Candido et al.
Journal of pharmaceutical sciences, 103(10), 3297-3301 (2014-08-08)
The incorporation of doxorubicin (DOX) in a microemulsion (DOX-ME) has shown beneficial consequences by reducing the cardiotoxic effects of DOX. The aim of this study was to determine the distribution of DOX-ME in Ehrlich solid tumor (EST) and the heart
Shunsuke Kanno et al.
Journal of immunology (Baltimore, Md. : 1950), 194(2), 773-780 (2014-12-10)
Atherosclerosis is essentially a vascular inflammatory process in the presence of an excess amount of lipid. We have recently reported that oral administration of a nucleotide-binding oligomerization domain (Nod)-1 ligand, FK565, induced vascular inflammation in vivo. No studies, however, have
Xiaobo He et al.
Environmental research, 137, 458-466 (2015-02-14)
Electronic waste (e-waste) has created a worldwide environmental and health problem, by generating a diverse group of hazardous compounds such as persistent organic pollutants (POPs). Our previous studies demonstrated that populations from e-waste exposed region have a significantly higher level
S Riedel et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 78, 96-104 (2015-02-07)
Changes in lipid metabolism have been associated with tumor promotion in rat liver. Similarities and differences of lipid parameters were investigated using the mycotoxin fumonisin B1 (FB1) and the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) treatments as cancer promoters in rat liver. A
Qian Ma et al.
Molecular pharmaceutics, 12(3), 665-674 (2015-01-15)
Probucol (PB), an antioxidant drug, is commonly used as a lipid concentration lowering drug to reduce blood plasma cholesterol levels in the clinic. However, the therapeutic effects of this drug are negatively impacted by its poor water solubility and low
Diana M Shih et al.
Journal of lipid research, 56(1), 22-37 (2014-11-08)
We performed silencing and overexpression studies of flavin containing monooxygenase (FMO) 3 in hyperlipidemic mouse models to examine its effects on trimethylamine N-oxide (TMAO) levels and atherosclerosis. Knockdown of hepatic FMO3 in LDL receptor knockout mice using an antisense oligonucleotide
Yannan Zhao et al.
Journal of lipid research, 55(10), 2053-2063 (2014-07-01)
We have observed that molecular constructs based on multiple apoA-I mimetic peptides attached to a branched scaffold display promising anti-atherosclerosis functions in vitro. Building on these promising results, we now describe chronic in vivo studies to assess anti-atherosclerotic efficacy of
Sheida Shariat et al.
Cancer letters, 355(1), 54-60 (2014-09-17)
Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based
Zachary B Armstrong et al.
The Canadian journal of cardiology, 30(9), 1096-1103 (2014-04-15)
Aortic valve sclerosis (AVS) is a chronic progressive disease involving lipid infiltration, inflammation, and tissue calcification. Despite its high prevalence, there are currently no clinically approved pharmaceuticals for the management of AVS. The objective of the current study was to
You-Cheol Hwang et al.
Acta diabetologica, 51(6), 941-946 (2014-05-13)
The association between atherogenic dyslipidemia (AD) and incident type 2 diabetes (T2D) in the low-risk group for T2D has not yet been determined. The aims of this study were to investigate whether AD, characterized by increased serum apoB and non-HDL
Jiang Ma et al.
Journal of ethnopharmacology, 162, 61-68 (2015-01-06)
Polygoni Multiflori Radix (PMR) has been traditionally used as a tonic and an anti-aging remedy for centuries; however, hepatic lesions linked to PMR have been frequently reported. This work attempted to investigate the hepatotoxic potential of PMR extract and the
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