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Interleukin-2 augments natural killer cell activity.
Henney CS
Nature, 291, 335-338 (1981)
Shuang Guan et al.
Immunopharmacology and immunotoxicology, 36(4), 290-296 (2014-06-27)
Abstract Alpinetin, a flavonoid compound extracted from the seeds of Alpinia katsumadai Hayata, has been known to possess antibacterial, anti-inflammatory and other important therapeutic activities. In the current study, we investigated alpinetin for its immunosuppressive effect on activation and cytokines
Olivia M Kenny et al.
Life sciences, 92(13), 775-782 (2013-03-05)
The potato glycoalkaloids, α-chaconine, α-solanine and solanidine, along with potato peel extracts were investigated for potential anti-inflammatory effects in vitro. Their potential to reduce two biomarkers of inflammation, cytokine and nitric oxide (NO) productions, were assessed in the stimulated Jurkat
Associations of IL-2 and IL-4 Expression and Polymorphisms With the Risks of Mycoplasma pneumoniae Infection and Asthma in Children.
Wang RS
Archivos de bronconeumologia, 51, 571-578 (2015)
Azita Haddadi et al.
Nanotechnology, 25(35), 355101-355101 (2014-08-15)
Mannan (MN) is the natural ligand for mannose receptors, which are widely expressed on dendritic cells (DCs). The purpose of this study was to assess the effect of formulation parameters on the immunogenicity of MN-decorated poly (D, L-lactide-co-glycolide) (PLGA) nanoparticles
Chen Liu et al.
Molecular medicine reports, 10(3), 1323-1328 (2014-07-26)
Melatonin, a widespread physiological mediator, has been demonstrated to exhibit a dose‑dependent immunoregulatory effect in vitro and in vivo, including mediating physiological circadian rhythms, neutralizing free radicals and exerting antisenescence actions. In the present study, the efficacy and mechanism of
Michael Weber et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20(11), 1696-1704 (2014-08-19)
Graft-versus-host disease (GVHD) is a frequent life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT) and induced by donor-derived T cells that become activated by host antigen-presenting cells. To address the relevance of host dendritic cell (DC) populations in this
Annemie Deiteren et al.
Gut, 63(12), 1873-1882 (2014-02-25)
Substantial evidence implicates mast cells and their main constituent histamine in the pathogenesis of visceral hypersensitivity. We explored the specific contribution of histamine H4 (H4R) and H1 (H1R) receptors to visceral hypersensitivity in a postinflammatory rat model. Trinitrobenzenesulfonic acid (TNBS)-colitis
Ning Zhao et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34(4), 1359-1372 (2014-10-11)
Acacetin, a natural flavonoid compound, has been proven to exert anti-inflammatory and immunomodulatory effects. Kv1.3 channels, highly expressed in human T cells, are attractive therapeutic targets to treat inflammatory and immunological disorders. The present study was designed to characterize the
BbvI & RsaI Restriction of AR-DBD, IL-6, IL-8, and SPF Discriminate Prostate Cancer
Hessien M, et al.
Biomedica : Revista del Instituto Nacional de Salud, 34(4), 236-236 (2018)
Microarray analysis of potential genes in the pathogenesis of recurrent oral ulcer.
Han J
International Journal of Clinical and Experimental Pathology, 8, 12419-12427 (2015)
Overview of interleukin-2 function, production and clinical applications.
Gaffen SL and Liu KD
Cytokine, 28(3), 109-123 (2004)
Yujo Kawashita et al.
Radiation research, 182(2), 191-200 (2014-06-28)
Hepatocellular carcinoma (HCC) often presents as a diffuse or multifocal tumor making it difficult to control by surgery or radiation. Radio-inducible herpes simplex virus thymidine kinase (HSV-TK) gene therapy has been shown to enhance local tumor control after radiation therapy
Lauriane Padet et al.
Immunobiology, 219(9), 687-694 (2014-05-31)
Allograft rejection and graft-versus-host disease (GvHD) are frequent complications following solid organ or stem cell transplantation in which T cell activation plays a central role. Despite the development of new immunosuppressive drugs that improve the success rate of transplantation, allograft
Jinxu Wang et al.
Journal of ethnopharmacology, 155(1), 405-415 (2014-06-21)
Shenqi Fuzheng Injection (SFI) is an injectable traditional Chinese herbal formula comprised of two Chinese herbs, Radix codonopsis and Radix astragali, which were commonly used to improve immune functions against chronic diseases in an integrative and holistic way in China
IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation.
Liao W
Current Opinion in Immunology, 23, 598-604 (2011)
Stacey X Xu et al.
Infection and immunity, 82(9), 3588-3598 (2014-06-11)
Staphylococcus aureus is a versatile bacterial pathogen that produces T cell-activating toxins known as superantigens (SAgs). Although excessive immune activation by SAgs can induce a dysregulated cytokine storm as a component of what is known as toxic shock syndrome (TSS)
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization.
Setoguchi R
The Journal of Experimental Medicine, 201, 723-735 (2005)
Sandeep Sharma et al.
Tuberculosis (Edinburgh, Scotland), 94(4), 389-396 (2014-06-02)
Piperine a trans-trans isomer of 1-piperoyl-piperidine was evaluated for its immunomodulatory activity to enhance the efficacy of rifampicin in a murine model of Mycobacterium tuberculosis infection. In-vitro immunomodulation of piperine was tested on mouse splenocytes for lymphocyte proliferation, cytokine production
Song Gao et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(6), 441-450 (2014-02-06)
CD200 is expressed on various cell types, including T cells, while the CD200 receptor (CD200R) is expressed on myeloid cells such as monocytes-derived macrophages (MDMs). The CD200-CD200R interaction has been shown to play an important role in the prevention of
The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.
Bamford RN
Proceedings of the National Academy of Sciences of the USA, 91, 4940-4944 (1994)
Igor Maricic et al.
Journal of immunology (Baltimore, Md. : 1950), 193(9), 4580-4589 (2014-09-28)
Lipids presented by the MHC class I-like molecule, CD1d, are recognized by NK T (NKT) cells, which can be broadly categorized into two subsets. The well-characterized type I NKT cells express a semi-invariant TCR and can recognize both α- and
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