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Jason Brocato et al.
Journal of toxicology and environmental health. Part A, 77(13), 751-766 (2014-05-21)
Airborne particulate matter (PM) exposure is a major environmental health concern and is linked to metabolic disorders, such as cardiovascular diseases (CVD) and diabetes, which are on the rise in the Kingdom of Saudi Arabia. This study investigated changes in
Bing Lin et al.
Journal of ethnopharmacology, 155(1), 248-255 (2014-05-28)
Xanthium strumarium L. fruit (Xanthiu fruit) has been traditionally used as a medicinal herb in China for the treatment of many ailments including rheumatoid arthritis. However, the anti-arthritic activity of Xanthium strumarium fruit has still not been demonstrated. In the
Apelin attenuates oxidative stress in human adipocytes.
Than A
The Journal of Biological Chemistry, 289(6), 3763-3774 (2014)
Jean Gaschignard et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 59(2), 244-251 (2014-04-25)
About 10% of pediatric patients with invasive pneumococcal disease (IPD) die from the disease. Some primary immunodeficiencies (PIDs) are known to confer predisposition to IPD. However, a systematic search for these PIDs has never been carried out in children presenting
Katie May Slattery et al.
Medicine and science in sports and exercise, 46(6), 1114-1123 (2014-03-01)
This investigation examined the ergogenic effect of short-term oral N-acetylcysteine (NAC) supplementation and the associated changes in redox balance and inflammation during intense training. A double-blind randomized placebo-controlled crossover design was used to assess 9 d of oral NAC supplementation
Hui Xu et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(2), R138-R148 (2014-05-16)
We determined the contribution of vascular large conductance Ca2+-activated K+ (BK) and L-type Ca2+ channel dysregulation to exaggerated mortality in cecal ligation/puncture (CLP)-induced septic BK channel β1-subunit knockout (BK β1-KO, smooth muscle specific) mice. CLP-induced hemodynamic changes and mortality were
Aung Than et al.
The Journal of biological chemistry, 289(6), 3763-3774 (2013-12-24)
It has been recently recognized that the increased oxidative stress (ROS overproduction) in obese condition is a key contributor to the pathogenesis of obesity-associated metabolic diseases. Apelin is an adipocytokine secreted by adipocytes, and known for its anti-obesity and anti-diabetic
Soo Kyung Jeong et al.
International immunopharmacology, 22(2), 303-310 (2014-07-22)
Macrophages are capable of both inhibiting and promoting the growth and spread of cancers, depending on their activation state. Tumor-associated macrophages (TAM) are a kind of alternatively activated M2 macrophage, which may contribute to tumor progression. Following our previous study
Jan M Hughes-Austin et al.
Vascular medicine (London, England), 19(4), 264-271 (2014-06-08)
Adipokines regulate metabolic processes linked to coronary artery (CAC) and abdominal aorta calcification (AAC). Because adipokine and other adiposity-associated inflammatory marker (AAIM) secretions differ between visceral and subcutaneous adipose tissue, we hypothesized that central adiposity modifies associations between AAIMs and
Dan Guo et al.
Acta pharmacologica Sinica, 35(6), 770-778 (2014-04-22)
Cyclovirobuxinum D (CVB-D), an alkaloid isolated from the Chinese medicinal plant Buxus microphylla, has been found to be effective to treat cardiac insufficiency, arrhythmias and coronary heart disease. In the present study, we investigated the effects of CVB-D on the
Wenjing Cheng et al.
Molecular medicine reports, 10(4), 2172-2176 (2014-07-23)
Heat shock protein (HSP)60 is primarily a mitochondrial protein. Previous experiments have found that changes in the location of intracellular HSP60 have been associated with apoptosis. Extracellular HSP60 mediates apoptosis via its ligand, Toll‑like receptor (TLR)-4. TLR-4 is an important
Saori Nagao et al.
Biomaterials, 35(24), 6553-6562 (2014-05-09)
Carbon monoxide (CO) has potent anti-inflammatory and anti-oxidant effects. We report herein on the preparation of a nanotechnology-based CO donor, CO-bound hemoglobin-vesicles (CO-HbV). We hypothesized that CO-HbV could have a therapeutic effect on idiopathic pulmonary fibrosis (IPF), an incurable lung
Katherine M Baumgarner et al.
Behavioural brain research, 267, 33-41 (2014-03-25)
Obesity increases susceptibility for numerous diseases and neurological disorders including cardiovascular disease, metabolic syndrome, and dementia. One factor that may contribute to the increased risk for these conditions is the development of chronic inflammation. The current study evaluated whether diet-induced
ZhanTao Zhu et al.
Alcoholism, clinical and experimental research, 38(6), 1510-1519 (2014-05-07)
Alcoholic liver disease (ALD) continues to be a major cause of morbidity worldwide. The exact mechanisms for ALD pathogenesis are not fully understood. There is currently no known available drug for ALD. Previous studies have suggested that ethanol (EtOH)-induced hepatic
Paulette M Tamashiro et al.
Cancer cell international, 14(1), 76-76 (2014-09-10)
Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive loco-regional invasion. Sphingosine kinase1 (SphK1), an enzyme in sphingolipid metabolism, is emerging as a key player in HNSCC pathology. The observation that SphK1 is overexpressed in all HNSCC stages
Asma Shaikh-Kader et al.
Oxidative medicine and cellular longevity, 2021, 6667812-6667812 (2021-02-26)
Chemicals and signaling molecules released by injured cells at the beginning of wound healing prompt inflammation. In diabetes, prolonged inflammation is one of the probable causes for delayed wound healing. Increased levels of cyclooxygenase-2 (cox-2), interleukin-6 (IL-6), and tumour necrosis
Xuefang Jing et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 3055-3069 (2014-08-13)
Aberrant immune response and changes in the gut microflora are the main causes of inflammatory bowel disease (IBD). Peptidoglycan recognition proteins (Pglyrp1, Pglyrp2, Pglyrp3, and Pglyrp4) are bactericidal innate immunity proteins that maintain normal gut microbiome, protect against experimental colitis
Takuma Yoshizumi et al.
Nature communications, 5, 4713-4713 (2014-08-21)
Mitochondria contribute to cellular innate immunity against RNA viruses. Mitochondrial-mediated innate immunity is regulated by signalling molecules that are recruited to the mitochondrial membrane, and depends on the mitochondrial inner membrane potential (Δψm). Here we examine the physiological relevance of
K Hultman et al.
Journal of thrombosis and haemostasis : JTH, 12(5), 701-712 (2014-03-13)
Excess fibrin in blood vessels is cleared by plasmin, the key proteolytic enzyme in fibrinolysis. Neurological disorders and head trauma can result in the disruption of the neurovasculature and the entry of fibrin and other blood components into the brain
Sita Virakul et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 252(7), 1101-1109 (2014-05-31)
Graves' ophthalmopathy (GO) remains hard to treat. Excessive orbital fibroblast activation by platelet-derived growth factor (PDGF)-BB contributes to GO. The tyrosine kinase inhibitors (TKIs) imatinib mesylate and dasatinib both target PDGF-receptor tyrosine kinase activity, albeit with a different potency. We
Junrui Cheng et al.
Frontiers in nutrition, 8, 723480-723480 (2021-10-15)
Background: Carotenoids are naturally occurring pigments accounting for the brilliant colors of fruits and vegetables. They may display antioxidant and anti-inflammatory properties in humans besides being precursors to vitamin A. There is a gap of knowledge in examining their role
Cheng-Gui Miao et al.
Biochimie, 106, 149-156 (2014-09-10)
Rheumatoid arthritis (RA) is an autoimmune and progressive systemic disease of unknown etiology. Research shows that fibroblast-like synoviocytes (FLS) participate in the cartilage erosion, synovial hyperplasia, inflammatory cytokine secretion and suggests that fibroblast-like synoviocytes (FLS) display a crucial role in
Monika Bociąga-Jasik et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 23(4), 539-549 (2014-08-29)
Taking into consideration the aging of HIV infected individuals, changes in the metabolism aggravated by the antiretroviral therapy significantly impact their health. Mechanisms responsible for lipodystrophy, dyslipidemia and insulin resistance (IR) occurrence have not been completely understood. Only recently, the
Xiang Gao et al.
Journal of bioscience and bioengineering, 118(4), 476-481 (2014-04-12)
Trimethylamine N-oxide (TMAO) is an oxidation product of trimethylamine (TMA) and is present in many aquatic foods. Here, we investigated the effects of TMAO on glucose tolerance in high fat diet (HFD)-fed mice. Male C57BL/6 mice were randomly assigned to
Roland Schmitt et al.
Journal of immunology (Baltimore, Md. : 1950), 193(1), 317-326 (2014-05-23)
IgA nephropathy (IgAN) is characterized by mesangial cell proliferation and extracellular matrix expansion associated with immune deposits consisting of galactose-deficient polymeric IgA1 and C3. We have previously shown that IgA-binding regions of streptococcal M proteins colocalize with IgA in mesangial
Ana Hagiu et al.
Clinical oral investigations, 24(7), 2375-2383 (2019-10-28)
This in vitro study aimed to analyze the anti-inflammatory and wound healing potential of green tea extract (GTE) in human gingival epithelial keratinocytes (HGEK) treated with lipopolysaccharides (LPS). A cell viability assay was conducted using MTT to determine nontoxic levels
Ying Ju et al.
Vaccine, 32(23), 2703-2711 (2014-04-05)
The commonly used inactivated or split influenza vaccines induce only induce minimal T cell responses and are less effective in preventing heterologous virus infection. Thus, developing cross-protective influenza vaccines against the spread of a new influenza virus is an important
Christina Purnama et al.
European journal of immunology, 44(7), 2003-2012 (2014-04-02)
Alveolar macrophages (AMs), localized at the pulmonary air-tissue interface, are one of the first lines of defense that interact with inhaled airborne pathogens such as influenza viruses. By using a new CD169-DTR transgenic mouse strain we demonstrate that specific and
Frederick W McMahon et al.
Investigative ophthalmology & visual science, 55(10), 7019-7028 (2014-10-04)
A role for a bacterium, Bacillus oleronius, originally isolated from a Demodex mite, in the induction of ocular rosacea has been proposed. The aim of this work was to characterize the response of a corneal epithelial cell line to Bacillus
Stuart J Gallagher et al.
Pigment cell & melanoma research, 27(6), 1126-1137 (2014-06-14)
The transcription factor NF-kappaB (NF-kB) is a key regulator of cytokine and chemokine production in melanoma and is responsible for symptoms such as anorexia, fatigue, and weight loss. In addition, NF-kB is believed to contribute to progression of the disease
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