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Jingjing Li et al.
Neural plasticity, 2019, 7920540-7920540 (2019-03-27)
We investigated the effects of aerobic exercise on the expression of hippocampal synaptic plasticity-associated proteins in rats with type 2 diabetes and their possible mechanisms. A type 2 diabetes rat model was established with 8 weeks of high-fat diet combined
Amanda C Okolie et al.
Bioscience reports, 39(2) (2017-08-10)
Recent studies have shown that Type 2 diabetes (T2D) in rats can result through a synergy that links obesity to insulin resistance and β-cell dysfunction. The present study achieved T2D via high fructose (20%w/v, p.o.), streptozotocin single dose (40 mg/kg
Uddipak Rai et al.
Life sciences, 236, 116836-116836 (2019-09-08)
The present experiment was conceptualised to explore the therapeutic response of tetramethylpyrazine (TMP), a major active constituent of Ligusticum chuanxiong, a Chinese traditional medicinal plant, in high-fat diet (HFD)-streptozotocin (STZ)-induced diabetes in rats and to identify the possible mechanism of
Stella Maris Honoré et al.
Journal of obesity, 2018, 5341384-5341384 (2018-12-05)
Smallanthus sonchifolius (yacon), a native plant of South America, was observed to improve lipid profile in rodents and humans. This study aimed to investigate the antiobesity properties of yacon roots in a high-fat-diet (HFD) model and the underlying mechanisms. A
Gregory G Martin et al.
Lipids, 55(4), 309-327 (2020-04-22)
Ad libitum-fed diets high in fat and carbohydrate (especially fructose) induce weight gain, obesity, and nonalcoholic fatty liver disease (NAFLD) in humans and animal models. However, interpretation is complicated since ad libitum feeding of such diets induces hyperphagia and upregulates
David Rotter et al.
EMBO reports, 19(12) (2018-11-06)
Increasing non-shivering thermogenesis (NST), which expends calories as heat rather than storing them as fat, is championed as an effective way to combat obesity and metabolic disease. Innate mechanisms constraining the capacity for NST present a fundamental limitation to this
Tian Shen et al.
Experimental and therapeutic medicine, 16(4), 3121-3128 (2018-09-15)
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease. It is asymptomatic at presentation and is frequently identified among individuals with metabolic dysfunction, including obesity and diabetes. NAFLD is primarily characterized by the accumulation of triacylglycerol in the
Simone de Oliveira et al.
Obesity (Silver Spring, Md.), 29(1), 116-124 (2020-11-07)
The purpose of this study was to evaluate the effects of zinc (Zn) supplementation on metabolic and neuroinflammatory parameters in cafeteria diet (CAF)-induced obesity in Wistar rats. Animals were divided into four groups: control diet (CT); CT+Zn; CAF; CAF+Zn. The
Jingjing Li et al.
Behavioural brain research, 364, 447-456 (2017-11-09)
Diabetes could negatively affect the structures and functions of the brain, especially could cause the hippocampal dysfunction, however, the potential metabolic mechanism is unclear. The aim of this study was to investigate the changes of glucose metabolism in hippocampus of
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