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Jasper M A de Jong et al.
American journal of physiology. Endocrinology and metabolism, 308(12), E1085-E1105 (2015-04-23)
The nature of brown adipose tissue in humans is presently debated: whether it is classical brown or of brite/beige nature. The dissimilar developmental origins and proposed distinct functions of the brown and brite/beige tissues make it essential to ascertain the
Agnes Schröder et al.
Immunology and cell biology, 99(1), 84-96 (2020-09-06)
Myeloid cells regulate bone density in response to increased salt (NaCl) intake via the osmoprotective transcription factor, nuclear factor of activated T cells-5 (NFAT-5). Because orthodontic tooth movement (OTM) is a pseudoinflammatory immunological process, we investigated the influence of NaCl
Eleanor C Warren et al.
Cells, 10(11) (2021-11-28)
Ketogenic diets, used in epilepsy treatment, are considered to work through reduced glucose and ketone generation to regulate a range of cellular process including autophagy induction. Recent studies into the medium-chain triglyceride (MCT) ketogenic diet have suggested that medium-chain fatty
Agnes Schröder et al.
Mediators of inflammation, 2020, 5802435-5802435 (2020-08-25)
Apart from periodontal ligament fibroblasts, immune cells like macrophages also play an important mediating role in orthodontic tooth movement (OTM). Upon orthodontic force application to malpositioned teeth, macrophages in the periodontal ligament get exposed to both mechanical strain and hypoxic
Andrew L Eamens et al.
RNA (New York, N.Y.), 15(12), 2219-2235 (2009-10-29)
In Arabidopsis thaliana (Arabidopsis), DICER-LIKE1 (DCL1) functions together with the double-stranded RNA binding protein (dsRBP), DRB1, to process microRNAs (miRNAs) from their precursor transcripts prior to their transfer to the RNA-induced silencing complex (RISC). miRNA-loaded RISC directs RNA silencing of
Agnes Schröder et al.
BMC oral health, 21(1), 405-405 (2021-08-20)
Many adult orthodontic patients suffer from periodontitis, which is caused by oral pathogens such as the gram-negative Aggregatibacter actinomycetemcomitans (Agac). Like orthodontic tooth movement, periodontitis is associated with inflammation and alveolar bone remodelling thereby affecting orthodontic treatment. Interactions of both
Estrella Luna et al.
Plant physiology, 158(2), 844-853 (2011-12-08)
Systemic acquired resistance (SAR) is a plant immune response to pathogen attack. Recent evidence suggests that plant immunity involves regulation by chromatin remodeling and DNA methylation. We investigated whether SAR can be inherited epigenetically following disease pressure by Pseudomonas syringae
Rathindra N Bose et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(47), 18314-18319 (2008-11-21)
DNA is believed to be the molecular target for the cytotoxic activities of platinum (Pt) anticancer drugs. We report here a class of platinum(II)- and platinum(IV)-pyrophosphato complexes that exhibit cytotoxicity comparable with and, in some cases, better than cisplatin in
Mathew S Box et al.
Plant methods, 7, 7-7 (2011-03-15)
Many experiments in modern plant molecular biology require the processing of large numbers of samples for a variety of applications from mutant screens to the analysis of natural variants. A severe bottleneck to many such analyses is the acquisition of
Alonso J Pardal et al.
PLoS pathogens, 17(5), e1009572-e1009572 (2021-05-21)
Perception of microbes by plants leads to dynamic reprogramming of the transcriptome, which is essential for plant health. The appropriate amplitude of this transcriptional response can be regulated at multiple levels, including chromatin. However, the mechanisms underlying the interplay between
Francesco Paonessa et al.
Cell reports, 26(3), 582-593 (2019-01-17)
The neuronal microtubule-associated protein tau, MAPT, is central to the pathogenesis of many dementias. Autosomal-dominant mutations in MAPT cause inherited frontotemporal dementia (FTD), but the underlying pathogenic mechanisms are unclear. Using human stem cell models of FTD due to MAPT
Wei Wei et al.
Cell proliferation, 53(1), e12722-e12722 (2019-11-19)
The mechanisms underlying the effects of Toll-like receptor 9 (TLR9) and autophagy on rheumatoid arthritis (RA)-aggravated periodontitis are unclear. We aimed to explore a novel target, cathepsin K (Ctsk)-mediated TLR9-related autophagy, during the progress of periodontitis with RA. DBA/J1 mouse
Shane C Dillon et al.
Molecular microbiology, 76(5), 1250-1265 (2010-05-07)
The conjugative IncHI1 plasmid pSfR27 from Shigella flexneri 2a strain 2457T encodes the Sfh protein, a paralogue of the global transcriptional repressor H-NS. Sfh allows pSfR27 to be transmitted to new bacterial hosts with minimal impact on host fitness, providing
Karim Sorefan et al.
Nature, 459(7246), 583-586 (2009-05-30)
Local hormone maxima are essential for the development of multicellular structures and organs. For example, steroid hormones accumulate in specific cell types of the animal fetus to induce sexual differentiation and concentration peaks of the plant hormone auxin direct organ
Issei S Shimada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(23), 7926-7940 (2012-06-08)
In response to stroke, subpopulations of cortical reactive astrocytes proliferate and express proteins commonly associated with neural stem/progenitor cells such as glial fibrillary acidic protein (GFAP) and Nestin. To examine the stem cell-related properties of cortical reactive astrocytes after injury
Julia Tischler et al.
The EMBO journal, 38(1) (2018-09-28)
An intricate link is becoming apparent between metabolism and cellular identities. Here, we explore the basis for such a link in an in vitro model for early mouse embryonic development: from naïve pluripotency to the specification of primordial germ cells (PGCs).
Rachy Abraham et al.
Journal of proteomics, 120, 126-141 (2015-03-19)
Global re-emergence of Chikungunya virus (CHIKV) has renewed the interest in its cellular pathogenesis. We subjected CHIKV-infected Human Embryo Kidney cells (HEK293), a widely used cell-based system for CHIKV infection studies, to a high throughput expression proteomics analysis by Liquid
Gensheng Wang et al.
Journal of andrology, 30(3), 338-348 (2009-01-13)
Testosterone acting through the androgen receptor (AR) maintains the arrest of spermatogonial differentiation in juvenile spermatogonial depletion (jsd mutation in the Utp14b gene) mutant adult male mice. It is not known which of the somatic cell types expressing AR mediates
Temporal dynamics of myelination in the zebrafish spinal cord
Buckley C E, et al.
Glia, 58(7), 802-812 (2010)
Deron R Herr et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(6), 1474-1478 (2007-02-09)
Hearing requires the transduction of vibrational forces by specialized epithelial cells in the cochlea known as hair cells. The human ear contains a finite number of terminally differentiated hair cells that, once lost by noise-induced damage or toxic insult, can
Jennifer L Lucitti et al.
American journal of physiology. Heart and circulatory physiology, 309(7), H1141-H1150 (2015-08-16)
The number and diameter of native collaterals in tissues of healthy mice vary widely, resulting in large differences in tissue injury in occlusive diseases. Recent studies suggest similar variation may exist in humans. Collateral variation in mice is determined by
Benoit Guillemette et al.
PLoS genetics, 7(3), e1001354-e1001354 (2011-04-13)
Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification whose role in the regulation of gene expression has been extensively studied. In contrast, the function of H3K4 acetylation (H3K4ac) has received little attention because of a lack
Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington?s disease transgenic mice
Pang TYC, et al.
Neuroscience, 141(2), 569-584 (2006)
Rosemari Otton et al.
Frontiers in nutrition, 8, 715859-715859 (2021-09-07)
The potential ability of nutritional compounds to induce or enhance the browning of adipocytes has attracted large interest as a workable means of combatting the obesity epidemic. Green tea compounds are discussed as such inducers of an enhanced thermogenic capacity
Xiang Li et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 4764-4782 (2020-02-07)
Damage or degeneration of inner ear spiral ganglion neurons (SGNs) causes hearing impairment. Previous in vitro studies indicate that cochlear glial cells can be reprogrammed into SGNs, however, it remains unknown whether this can occur in vivo. Here, we show
Alonso J Pardal et al.
PLoS pathogens, 17(5), e1009572-e1009572 (2021-05-21)
Perception of microbes by plants leads to dynamic reprogramming of the transcriptome, which is essential for plant health. The appropriate amplitude of this transcriptional response can be regulated at multiple levels, including chromatin. However, the mechanisms underlying the interplay between
Ayman E El-Sahar et al.
The international journal of neuropsychopharmacology, 24(2), 158-169 (2020-10-31)
Endotoxin-induced neuroinflammation plays a crucial role in the pathogenesis and progression of various neurodegenerative diseases. A growing body of evidence supports that incretin-acting drugs possess various neuroprotective effects that can improve learning and memory impairments in Alzheimer's disease models. Thus
Chih-Yao Chung et al.
Nature communications, 12(1), 6409-6409 (2021-11-06)
Mutations of the mitochondrial genome (mtDNA) cause a range of profoundly debilitating clinical conditions for which treatment options are very limited. Most mtDNA diseases show heteroplasmy - tissues express both wild-type and mutant mtDNA. While the level of heteroplasmy broadly
Jasper M A de Jong et al.
American journal of physiology. Endocrinology and metabolism, 312(6), E508-E518 (2017-02-23)
Brown and brite/beige adipocytes are attractive therapeutic targets to treat metabolic diseases. To maximally utilize their functional potential, further understanding is required about their identities and their functional differences. Recent studies with β
Nataly Naser Al Deen et al.
Scientific reports, 11(1), 2626-2626 (2021-01-31)
mRNA-circRNA-miRNAs axes have been characterized in breast cancer, but not as risk-assessment axes for tumor initiation in early-onset breast cancer that is increasing drastically worldwide. To address this gap, we performed circular RNA (circRNA) microarrays and microRNA (miRNA) sequencing on
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