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Hyung Suk Oh et al.
mBio, 6(3), e00345-e00315 (2015-05-28)
We have shown previously that A-type lamins and intranuclear localization of the herpes simplex virus (HSV) genome are critical for the formation of the VP16 activator complex on HSV immediate-early (IE) gene promoters in murine cells, which implies a critical
Irene Gallina et al.
Nature communications, 6, 6533-6533 (2015-03-31)
DNA replication stress is a source of genomic instability. Here we identify changed mutation rate 1 (Cmr1) as a factor involved in the response to DNA replication stress in Saccharomyces cerevisiae and show that Cmr1--together with Mrc1/Claspin, Pph3, the chaperonin
Anne-Theres Henze et al.
Nature communications, 5, 5582-5582 (2014-11-26)
Solid tumours are exposed to microenvironmental factors such as hypoxia that normally inhibit cell growth. However, tumour cells are capable of counteracting these signals through mechanisms that are largely unknown. Here we show that the prolyl hydroxylase PHD3 restrains tumour
Evelyn E Newby et al.
International dental journal, 63 Suppl 2, 39-47 (2014-01-10)
To compare the effect of 40 seconds versus 2 minutes brushing on saliva and dental biofilm fluid fluoride in children ages 4-5 years over 1 hour. This was a single-blind, cross-over, randomised, two-period clinical study in healthy children. Three days
Shingo Shimada et al.
Surgery today, 45(7), 892-903 (2014-11-05)
Hydrogen sulfide (H2S) ameliorates hepatic ischemia and reperfusion injury (IRI), but the precise mechanism remains elusive. We investigated whether sodium hydrogen sulfide (NaHS), a soluble derivative of H2S, would ameliorate hepatic IRI, and if so, via what mechanism. Mice were
L N Munsie et al.
Human molecular genetics, 24(6), 1691-1703 (2014-11-25)
Vacuolar protein sorting 35 (VPS35) is a core component of the retromer complex, crucial to endosomal protein sorting and intracellular trafficking. We recently linked a mutation in VPS35 (p.D620N) to familial parkinsonism. Here, we characterize human VPS35 and retromer function
Patrick Scheiermann et al.
Scientific reports, 5, 8521-8521 (2015-02-18)
Overdosing of the analgesic acetaminophen (APAP, paracetamol) is a major cause of acute liver injury. Whereas toxicity is initiated by hepatocyte necrosis, course of disease is regulated by mechanisms of innate immunity having the potential to serve in complex manner
Huiqing Liang et al.
International journal of molecular sciences, 16(11), 27749-27756 (2015-11-28)
Gardenoside is one of the most important effective extractions of a herb for its hepatoprotective properties. The aim of this study was to address the mechanism of Gardenoside on HepG2 cellular steatosis induced by free fatty acids (FFAs). The model
Young-Eui Kim et al.
PLoS pathogens, 11(3), e1004785-e1004785 (2015-03-27)
Promyelocytic leukemia protein (PML), a major component of PML nuclear bodies (also known as nuclear domain 10), is involved in diverse cellular processes such as cell proliferation, apoptosis, gene regulation, and DNA damage response. PML also acts as a restriction
Yalan Xing et al.
Nature communications, 6, 7058-7058 (2015-05-12)
Many types of normal and cancer stem cells are resistant to killing by genotoxins, but the mechanism for this resistance is poorly understood. Here we show that adult stem cells in Drosophila melanogaster germline and midgut are resistant to ionizing
Bruna L B Pereira et al.
Nutrients, 7(11), 9640-9649 (2015-11-28)
The aim of this study was to evaluate the effects of tomato supplementation on the normal rat heart and the role of oxidative stress in this scenario. Male Wistar rats were assigned to two groups: a control group (C; n
Lenka Roubalová et al.
Bioorganic & medicinal chemistry, 23(17), 5402-5409 (2015-08-12)
Quercetin 3'-O-sulfate is one of the main metabolites of the natural flavonoid quercetin in humans. This study was designed to prepare quercetin 3'-O-sulfate (1), isoquercitrin 4'-O-sulfate (2) and taxifolin 4'-O-sulfate (3) by the sulfation of quercetin, isoquercitrin (quercetin 3-O-glucoside) and
Dominik Bogen et al.
Oncotarget, 6(34), 35247-35262 (2015-10-27)
Despite advances in multimodal treatment, neuroblastoma (NB) is often fatal for children with high-risk disease and many survivors need to cope with long-term side effects from high-dose chemotherapy and radiation. To identify new therapeutic targets, we performed an siRNA screen
J Juhasova et al.
Cellular and molecular neurobiology, 35(1), 57-70 (2014-12-10)
Expression of doublecortin (DCX), a 43-53 kDa microtubule binding protein, is frequently used as (i) an early neuronal marker to identify the stage of neuronal maturation of in vivo grafted neuronal precursors (NSCs), and (ii) a neuronal fate marker transiently
Frank Lippert et al.
Caries research, 49(5), 467-476 (2015-08-01)
The aims of this laboratory study were to compare the effects of lesion baseline severity, mineral distribution and substrate on remineralization and progression of caries lesions created in root dentin. Lesions were formed in dentin specimens prepared from human and
Jianwei Zuo et al.
Oncology reports, 33(3), 1388-1394 (2015-01-13)
The aim of the present study was to investigate whether pristimerin affects the bone metastasis, stem cell characteristics and epithelial-mesenchymal transition (EMT) of prostate cancer (PCa) PC-3 cells subjected to hypoxia. The PC-3 cells were cultured under hypoxia or normoxia
Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells via the regulation of Notch3
Zou B, et al.
Oncology Reports, 38(3), 1431-1441 (2017)
Lin Lin et al.
Biochemical and biophysical research communications, 463(3), 434-439 (2015-06-04)
Histamine and TGF-β, major mediators secreted by mast cells, are involved in skin inflammation and play critical roles in the pathogenesis of systemic sclerosis. However, the roles of signaling mechanisms in the development of skin fibrosis remain largely unclear. Here
Takuro Mizukami et al.
International journal of oncology, 47(2), 499-505 (2015-06-18)
Since the prognosis of unresectable advanced gastric cancer remains poor, novel therapeutic strategies are needed. Somatic MEK1 gene mutations have been reported as oncogenic activating mutations in gastric cancer, and MEK inhibitors can be effective against such gastric cancers. In
Harvey W Smith et al.
Nature communications, 10(1), 2901-2901 (2019-07-03)
Dysregulation of histone modifications promotes carcinogenesis by altering transcription. Breast cancers frequently overexpress the histone methyltransferase EZH2, the catalytic subunit of Polycomb Repressor Complex 2 (PRC2). However, the role of EZH2 in this setting is unclear due to the context-dependent
Ting-Fang Che et al.
Oncotarget, 6(35), 37349-37366 (2015-10-27)
Dysfunction of the mitochondria is well-known for being associated with cancer progression. In the present study, we analyzed the mitochondria proteomics of lung cancer cell lines with different invasion abilities and found that EGFR is highly expressed in the mitochondria
K P Sharma et al.
Indian journal of experimental biology, 50(12), 897-903 (2013-08-31)
Protective role of diet supplements (Spirulina, tamarind fruit pulp and their combination) on a freshwater fish G. affinis exposed at sublethal concentration of fluoride (F-) (10 ppm), Al(+3) (3 ppm) and aluminum fluoride (AlF3) (35.4 ppm) in the microcosms (15
Fei Niu et al.
Journal of cellular physiology, 230(9), 2212-2223 (2015-02-07)
Hypoxia is widely present in pancreatic cancer and subsequently causes the overexpression of hypoxia-inducible factor-1α (HIF-1α) and signal transducer and activator of transcription-3 (Stat3). HIF-1α and Stat3 function cooperatively to regulate a number of downstream genes that are implicated in
Partha S Ghosal et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 51(1), 86-96 (2015-11-10)
Response surface methodology was applied for the first time in the optimization of the preparation of layered double hydroxide (LDH) for defluoridation. The influence of three vital process parameters (viz. pH, molar ratio and calcination temperature) in the synthesis of
Robert J Huber et al.
PloS one, 9(10), e110544-e110544 (2014-10-21)
The neuronal ceroid lipofuscinoses (NCL) are a group of inherited, severe neurodegenerative disorders also known as Batten disease. Juvenile NCL (JNCL) is caused by recessive loss-of-function mutations in CLN3, which encodes a transmembrane protein that regulates endocytic pathway trafficking, though
Hyeon Soo Eom et al.
International journal of radiation biology, 91(7), 585-595 (2015-04-29)
The influence of ionizing radiation (IR) on neuronal differentiation is not well defined. In this study, we investigated the effects of IR on the differentiation of Neuro-2a mouse neuroblastoma cells and the involvement of tumor protein 53 (p53) and mitogen-activated
Youngsil Choi et al.
The Journal of biological chemistry, 290(27), 16943-16953 (2015-05-17)
Syndecans, a family of transmembrane heparansulfate proteoglycans, are known to interact through their transmembrane domains to form non-covalently linked homodimers, a process essential for their individual functions. Because all syndecan transmembrane domains are highly conserved and thus might mediate interactions
Wenxiao Jiang et al.
PloS one, 10(7), e0134142-e0134142 (2015-08-01)
Huntington disease (HD) represents a family of neurodegenerative diseases that are caused by misfolded proteins. The misfolded proteins accumulate in the affected brain regions in an age-dependent manner to cause late-onset neurodegeneration. Transgenic mouse models expressing the HD protein, huntingtin
Hagai Ligumsky et al.
Molecular cancer research : MCR, 13(10), 1398-1407 (2015-06-27)
Klotho is a transmembrane protein containing two internal repeats, KL1 and KL2, both displaying significant homology to members of the β-glycosidase family. Klotho is expressed in the kidney, brain, and various endocrine tissues, but can also be cleaved and act
Congshan Sun et al.
BMC developmental biology, 15, 3-3 (2015-01-23)
Dietary interventions during pregnancy alter offspring fitness. We have shown mouse maternal low protein diet fed exclusively for the preimplantation period (Emb-LPD) before return to normal protein diet (NPD) for the rest of gestation, is sufficient to cause adult offspring
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