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W4502

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Panagiotis A Vorkas et al.
International journal of cardiology, 197, 192-199 (2015-07-05)
Controversy exists concerning the beneficial or harmful effects of the presence of ectopic calcification in the coronary arteries. Additionally, further elucidation of the exact pathophysiological mechanism is needed. In this study, we sought to identify metabolic markers of vascular calcification...
Adam Mechler et al.
Biochimica et biophysica acta, 1838(11), 2939-2946 (2014-08-17)
Lipid-mimetic metallosurfactant based luminophores are promising candidates for labeling phospholipid membranes without altering their biophysical characteristics. The metallosurfactants studied exhibit high structural and physicochemical similarity to phospholipid molecules, designed to incorporate into the membrane structure without the need for covalent...
Yanli Cui et al.
Carbohydrate research, 407, 51-54 (2015-02-24)
We herein report an efficient synthesis of β-glycosyl 1-ester in room-temperature ionic liquids (RTILs) promoted via silver salt and quaternary ammonium salt (PTC) with good or excellent yields. All products were isolated exclusively as the β-anomers. Four different RTILs, eight...
Francisco Miguel Cardoso et al.
Journal of virology, 88(15), 8278-8296 (2014-05-16)
Influenza virus neuraminidase (NA) is an interesting target of small-molecule antiviral drugs. We isolated a set of H5N1 NA-specific single-domain antibodies (N1-VHHm) and evaluated their in vitro and in vivo antiviral potential. Two of them inhibited the NA activity and...
Paola Stiuso et al.
Molecular therapy. Nucleic acids, 4, e233-e233 (2015-03-18)
Hepatocellular carcinoma (HCC) is the third cause of cancer-related deaths worldwide. Sorafenib is the only approved drug for patients with advanced HCC but has shown limited activity. microRNAs (miRs) have been involved in several neoplasms including HCC suggesting their use...
Thuy Nguyen et al.
Bioorganic & medicinal chemistry, 23(9), 2195-2203 (2015-03-24)
A series of substituted 1H-indole-2-carboxamides structurally related to compounds Org27569 (1), Org29647 (2) and Org27759 (3) were synthesized and evaluated for CB1 allosteric modulating activity in calcium mobilization assays. Structure-activity relationship studies showed that the modulation potency of this series...
Min-Soo Kim et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 62(9), 979-987 (2015-04-15)
Volume-controlled ventilation with a prolonged inspiratory to expiratory ratio (I:E ratio) has been used to optimize gas exchange and respiratory mechanics in various surgical settings. We hypothesized that, when compared with an I:E ratio of 1:2, a prolonged I:E ratio...
Morgan Solliec et al.
Rapid communications in mass spectrometry : RCM, 29(24), 2361-2373 (2015-11-14)
Swine manure can contain a wide range of veterinary antibiotics, which could enter the environment via manure spreading on agricultural fields. A suspect and non-target screening method was applied to swine manure samples to attempt to identify veterinary antibiotics and...
Faiezah A A Mohamed et al.
Drug development and industrial pharmacy, 41(1), 70-78 (2013-10-19)
The particle size of HPMC is a critical factor that can influence drug release rate from hydrophilic matrix systems. Percolation theory is a statistical tool which is used to study the disorder of particles in a lattice of a sample....
Hussein M Salahdeen et al.
Indian journal of experimental biology, 50(12), 883-888 (2013-08-31)
Tridax procumbens leaf extract induced aortic relaxation in a concentration-dependent manner, for both phenylephrine (PE) and KCl- induced contractions in isolated rat aortic rings. The relaxation effect of the extract on PE-induced contraction was 57% greater than that on KCl-...
Hyoung Woon Song et al.
Journal of the Air & Waste Management Association (1995), 64(12), 1384-1389 (2015-01-08)
The purpose of this study is to quantify the thermal conductivity of sewage sludge related to reaction temperature for the optimal design of a thermal hydrolysis reactor. We continuously quantified the thermal conductivity of dewatered sludge related to the reaction...
Arnaud M Wolfer et al.
Analytical chemistry, 87(23), 11721-11731 (2015-10-27)
Lipid mediators, highly bioactive compounds synthesized from polyunsaturated fatty acids (PUFAs), have a fundamental role in the initiation and signaling of the inflammatory response. Although extensively studied in isolation, only a limited number of analytical methods offer a comprehensive coverage...
Yasuhito Funahashi et al.
The Prostate, 75(4), 381-389 (2014-12-03)
Prostatic inflammation is reportedly associated with the development of prostatic hyperplasia. We investigated the effects of prostatic inflammation on expression levels of androgen-responsive genes and growth factors in the rat prostate. Prostatic inflammation was induced by Escherichia coli (strain 1677)...
Luca Mazzei et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(6), 1021-1037 (2015-07-25)
Helicobacter pylori (Hp) is a carcinogen that relies on Ni(II) to survive in the extreme pH conditions of the human guts. The regulation of genes coding for Ni(II) enzymes and proteins is effected by the nickel-responsive transcription factor NikR, composed...
Andreas Brink et al.
Rapid communications in mass spectrometry : RCM, 28(24), 2695-2703 (2014-11-08)
Analytical methods to assess glutathione (GSH) conjugate formation based on mass spectrometry usually take advantage of the specific fragmentation behavior of the glutathione moiety. However, most methods used for GSH adduct screening monitor only one specific neutral loss or one...
Zafar Khan Ghouri et al.
Scientific reports, 5, 16695-16695 (2015-11-17)
In this study, CoCu alloy nanoparticles-incorporated carbon nanofibers are introduced as effective non precious electrocatalyst for methanol oxidation in alkaline medium. The introduced electrocatalyst has been synthesized by simple and effective process; electrospinning. Typically, calcination, in nitrogen atmosphere, of electrospun...
Joanna A Majchrzykiewicz-Koehorst et al.
Journal of virological methods, 213, 75-83 (2014-12-17)
The rapid identification of existing and emerging respiratory viruses is crucial in combating outbreaks and epidemics. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid and reliable identification method in bacterial diagnostics, but has not been used in...
Marie-Laurence Tremblay et al.
Scientific reports, 5, 11502-11502 (2015-06-27)
Spiders store spidroins in their silk glands as high concentration aqueous solutions, spinning these dopes into fibres with outstanding mechanical properties. Aciniform (or wrapping) silk is the toughest spider silk and is devoid of the short amino acid sequence motifs...
Yadong Ge et al.
Biotechnology and applied biochemistry, 62(3), 300-308 (2015-03-19)
Citrate synthase (CS) is a key enzyme of the tricarboxylic acid cycle and is widely distributed among prokaryotes and eukaryotes. Here, we report for the first time, the cloning, expression, and characterization of a novel CS from Streptomyces diastaticus No....
Natália N Saraiva et al.
Natural product research, 29(16), 1545-1550 (2014-12-24)
A fungal strain of Aspergillus sp. (BRF 030) was isolated from the sediments collected in the northeast coast of Brazil, and the cytotoxic activity of its secondary metabolites was investigated against HCT-116 tumour cell line. The cytotoxicity-guided fractionation of the...
Qiang Zhang et al.
Food & function, 6(5), 1518-1525 (2015-03-31)
Flavonoids have been reported to exhibit prooxidant cytotoxicity against cancer cells, but the underlying mechanism is still poorly understood. Here we investigated the potential mechanism that p53-inducible gene 3 (PIG3), a NADPH:quinone oxidoreductase, mediated the prooxidant cytotoxicity of flavonoids on...
Nathalie Matusiak et al.
Bioorganic & medicinal chemistry, 23(1), 192-202 (2014-12-03)
Numerous clinical studies have shown a correlation between increased matrix metalloproteinase (MMP)/a disintegrin and metalloproteinase (ADAM) activity and poor outcome of cancer. Various MMP inhibitors (MMPIs) have been developed for therapeutic purposes in oncology. In addition, molecular imaging of MMP/ADAM...
Katsuhito Kondo et al.
Langmuir : the ACS journal of surfaces and colloids, 31(26), 7427-7434 (2015-06-14)
In addition to serving as an energy source for microbial growth, iron sulfides are proposed to act as naturally occurring electrical wires that mediate long-distance extracellular electron transfer (EET) and bridge spatially discrete redox environments. These hypothetical EET reactions stand...
Fabrice Gritti et al.
Journal of chromatography. A, 1356, 96-104 (2014-07-08)
Computer calculations of gradient chromatograms were performed by taking into account the adsorption behavior of the strong eluent in RPLC and the true Henry constant of the analytes. This improves the accuracy of classical gradient calculations, which all assume no...
I Imre et al.
Journal of fish biology, 84(5), 1490-1502 (2014-04-30)
Using semi-natural enclosures, this study investigated (1) whether adult sea lamprey Petromyzon marinus show avoidance of damage-released conspecific cues, damage-released heterospecific cues and predator cues and (2) whether this is a general response to injured heterospecific fishes or a specific...
Francisco Moral et al.
Water environment research : a research publication of the Water Environment Federation, 85(7), 632-642 (2013-08-16)
Andalusia's lowland countryside has a network of small geographically isolated playa lakes scattered across an area of 9000 km2 whose watersheds are mostly occupied by clayey rocks. The hydrological model proposed by the authors seeks to find equilibrium among usefulness...
Wenxin Yang et al.
Proteome science, 13, 19-19 (2015-08-01)
Vibrio parahaemolyticus is a common pathogen infecting humans and marine animals; this pathogen has become a major concern of marine food products and trade. In this study, V. parahaemolyticus isolated from sewage was exposed to different culture conditions and analyzed...
Tissue electrolytes in dehydrated children.
Nutrition reviews, 25(7), 205-207 (1967-07-01)
Juan Zhou et al.
Clinical and translational gastroenterology, 6, e101-e101 (2015-07-17)
Colorectal cancer initially lies dormant as dysplasia, a premalignant state that provides an opportunity for early cancer detection. Dysplasia can be flat in morphology, focal in size, and patchy in distribution, and thus it appears "invisible" on conventional wide-field endoscopy....
Xiuping Zhu et al.
Applied and environmental microbiology, 81(11), 3863-3868 (2015-03-31)
Microbial electrosynthesis (MES) systems with mixed cultures often generate a variety of gaseous and soluble chemicals. Methane is the primary end product in mixed-culture MES because it is the thermodynamically most favorable reduction product of CO2. Here, we show that...
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