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Curcumin effects on cell proliferation, angiogenesis and metastasis in colorectal cancer.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology (2019-10-28)
Gizem Calibasi-Kocal, Ahu Pakdemirli, Serdar Bayrak, Nazli Mert Ozupek, Tolga Sever, Yasemin Basbinar, Hulya Ellidokuz, Turkan Yigitbasi
ABSTRACT

Curcumin is a natural phytopolyphenol compound isolated from the root of turmeric (Curcuma longa) and possesses a wide range of biological properties. The purpose of this study was to evaluate the antiproliferative, wound healing, anti-invasive and anti-migrative effects of curcumin on HCT-116 and LoVo colorectal cancer cell lines. The antiproliferative activity of 2.5-75 µM curcumin was tested on HCT-116 and LoVo colorectal cell lines and the viability of the cells was tested with WST-1 reagent by using ELISA plate reader at 450 nm. xCELLigence RTCA DP system was used for the detection of anti-invasive and anti-migrative effects of curcumin. The IC50 of curcumin was 10±0.03 for HCT-116 and 20±0.05 µM for LoVo cell lines. The IC50 of curcumin (10µM for HCT-116 and 20 µM for LoVo) showed anti-metastatic activity on these cell lines. This study showed that curcumin could be evaluated as a promising anti-cancer agent for human colorectal cancer.

MATERIALS
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Brand
Product Description

Sigma-Aldrich
Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin)