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Hepatoprotective constituents from the roots and stems of Erycibe hainanesis.

Journal of natural products (2010-01-23)
Shuang Song, Yixiu Li, Ziming Feng, Jianshuang Jiang, Peicheng Zhang
ABSTRACT

Eleven new diglycosides, erycibosides A-K (1-11), four new chlorogenic acid derivatives (14-17), and a new bis-coumarin (18), together with 21 known compounds, have been isolated from an EtOH extract of the roots and stems of Erycibe hainanesis. Their structures were elucidated by means of spectroscopic methods and chemical evidence. Inhibitory activities of some of the compounds on d-galactosamine-induced cytotoxicity in WB-F344 rat hepatic epithelial stem-like cells were screened, and compounds 2, 6, 10, 18, and 32 showed potent hepatoprotective activities at concentrations of 1 x 10(-5) to 1 x 10(-4) M.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3,4-Dihydroxybenzoic acid, ≥97.0% (T)
Supelco
Caffeic acid, matrix substance for MALDI-MS, ≥99.0% (HPLC)
Sigma-Aldrich
Caffeic acid, ≥98.0% (HPLC)
Sigma-Aldrich
Chlorogenic acid, ≥95% (titration)
Sigma-Aldrich
Vanillic acid, 97%
Sigma-Aldrich
Vanillic acid, purum, ≥97.0% (HPLC)
Sigma-Aldrich
Vanillic acid, ≥97%, FG
Chlorogenic acid, primary reference standard