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Regio- and stereo-selective hydroxylation of abietic acid derivatives by Mucor circinelloides and Mortierella isabellina.

Biotechnology letters (2005-10-11)
Koichi Mitsukura, Takeshi Imoto, Hirokazu Nagaoka, Toyokazu Yoshida, Toru Nagasawa
ABSTRACT

Mucor circinelloides and Mortierella isabellina hydroxylated dehydroabietic acid (DehA). DehA was converted regio- and stereo-selectively by whole cells of Mr. circinelloides to give 2alpha-hydroxydehydroabietic acid in a 75% molar conversion yield (11 mM from 14.7 mM DehA) after 72 h in the cultivation medium containing 3% (v/v) Tween 80. With cells of Ma. isabellina, under the same conditions, 20.5 mM (6.5 g l(-1)) 2-hydroxydehydroabietic acid (alpha/beta=81/19) was formed from 26.4 mM DehA.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Dehydroabietic acid, ≥95% (LC/MS-ELSD)