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Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks.

Current opinion in biotechnology (2013-04-02)
Yun Chen, Jens Nielsen
ABSTRACT

Bio-based production of chemical building blocks from renewable resources is an attractive alternative to petroleum-based platform chemicals. Metabolic pathway and strain engineering is the key element in constructing robust microbial chemical factories within the constraints of cost effective production. Here we discuss how the development of computational algorithms, novel modules and methods, omics-based techniques combined with modeling refinement are enabling reduction in development time and thus advance the field of industrial biotechnology. We further discuss how recent technological developments contribute to the development of novel cell factories for the production of the building block chemicals: adipic acid, succinic acid and 3-hydroxypropionic acid.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Adipic acid, ≥99.5%
Sigma-Aldrich
Succinic acid, BioXtra, BioRenewable, ≥99.0%
Sigma-Aldrich
Succinic acid, BioReagent, BioRenewable, suitable for cell culture, suitable for insect cell culture
Sigma-Aldrich
Succinic acid, ReagentPlus®, BioRenewable, ≥99.0%
Supelco
Adipic acid, certified reference material, TraceCERT®
Supelco
Succinic acid, certified reference material, TraceCERT®
Sigma-Aldrich
Succinic acid, purum p.a., ≥99.0% (T)
Sigma-Aldrich
Succinic acid, ACS reagent, ≥99.0%
Sigma-Aldrich
Adipic acid, 99%
Sigma-Aldrich
Adipic acid, BioXtra, ≥99.5% (HPLC)
Sigma-Aldrich
Succinic acid, puriss. p.a., ACS reagent, ≥99.5% (T)