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Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata.

Phytochemistry (2014-12-10)
Nguyen Tuan Hiep, Jaeyoung Kwon, Dong-Woo Kim, Bang Yeon Hwang, Hak-Ju Lee, Woongchon Mar, Dongho Lee
ABSTRACT

Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 μM.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Dimethyl sulfoxide-d6, 99.9 atom % D
Sigma-Aldrich
Curcumin, from Curcuma longa (Turmeric), powder
Sigma-Aldrich
Dimethyl sulfoxide-d6, 99.9 atom % D, contains 0.03 % (v/v) TMS
Sigma-Aldrich
Acetone-d6, 99.9 atom % D
Sigma-Aldrich
Dimethyl sulfoxide-d6, "100%", 99.96 atom % D
Sigma-Aldrich
Dimethyl sulfoxide-d6, 99.5 atom % D
Sigma-Aldrich
Acetone-d6, 99.9 atom % D
Sigma-Aldrich
Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin)
Supelco
Curcumin, analytical standard
Sigma-Aldrich
Acetone-d6, 99.9 atom % D, contains 0.03 % (v/v) TMS
Sigma-Aldrich
Dimethyl sulfoxide-d6, "100%", 99.96 atom % D, contains 0.03 % (v/v) TMS
Sigma-Aldrich
Dimethyl sulfoxide-d6, 99.9 atom % D, contains 1 % (v/v) TMS
Supelco
Curcumin, matrix substance for MALDI-MS, ≥99.5% (HPLC)
Sigma-Aldrich
Dimethyl sulfoxide-d6, anhydrous, 99.9 atom % D
USP
Curcumin, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Dimethyl sulfoxide-d6, "Special HOH", ≥99.9 atom % D
Sigma-Aldrich
Acetone-d6, "100%", 99.96 atom % D
Curcumin, primary reference standard
Sigma-Aldrich
Acetone-d6, 99.9 atom % D, contains 1 % (v/v) TMS
Sigma-Aldrich
Acetone-d6, 99.9 atom % D
Sigma-Aldrich
Dimethyl sulfoxide-d6, "100%", 99.96 atom % D
Sigma-Aldrich
Dimethyl sulfoxide-d6, "100%", 99.96 atom % D
Sigma-Aldrich
Acetone-d6, ≥99.9 atom % D, contains 0.03 % (v/v) TMS
Sigma-Aldrich
Acetone-d6, "100%", 99.96 atom % D
Sigma-Aldrich
Acetone-d6, 99.5 atom % D
Sigma-Aldrich
Acetone-d6, 99.9 atom % D