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Limonoids from the Seeds of Swietenia macrophylla and Their Anti-Inflammatory Activities.

Molecules (Basel, Switzerland) (2015-10-17)
Li-Chai Chen, Hsiang-Ruei Liao, Pei-Yu Chen, Wen-Lung Kuo, Tsung-Hsien Chang, Ping-Jyun Sung, Zhi-Hong Wen, Jih-Jung Chen
ABSTRACT

A new limonoid, swietemacrophin (1), was isolated from the seeds of Swietenia macrophylla, together with five known compounds 2-6. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Swietemacrophin (1), humilinolide F (2), 3,6-O,O-diacetylswietenolide (3), 3-O-tigloylswietenolide (4), and swietemahonin E (5) exhibited inhibition (IC50 values≤45.44 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP). Compounds 1, 4, 5, and swietenine (6) showed potent inhibition with IC50 values≤36.32 μM, against lipopolysaccharide (LPS)-induced nitric oxide (NO) generation.

MATERIALS
Product Number
Brand
Product Description

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