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  • Self-aggregates of 3,6-O,O'-dimyristoylchitosan derivative are effective in enhancing the solubility and intestinal permeability of camptothecin.

Self-aggregates of 3,6-O,O'-dimyristoylchitosan derivative are effective in enhancing the solubility and intestinal permeability of camptothecin.

Carbohydrate polymers (2017-10-01)
Daniella S Silva, Andreia Almeida, Fabíola G Prezotti, William M Facchinatto, Luiz A Colnago, Sérgio P Campana-Filho, Bruno Sarmento
ABSTRACT

The aim of this work was to investigate the potential of a new 3,6-O,O'-dimyristoyl derivative amphiphilic chitosan (DMCh), in improving the solubility of camptothecin (CPT), a hydrophobic anticancer drug, and its potential oral delivery. FTIR,

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
8-Cyclopentyl-1,3-dimethylxanthine, ≥98% (HPLC), powder
Sigma-Aldrich
D-Glucose-12C6, 99.5 atom % 12C