When a C18 doesn′t give the desired separation, or your sample contains compounds that are known to be difficult to retain or resolve on a C18, consider changing to an Ascentis® Express C8 column. The Ascentis® Express C8 can be the ideal phase for non-polar compounds that are retained too strongly by a traditional C18 column.
The Fused-Core® particle technology of the Ascentis® Express C8 column enables high speed and high resolution separations on HPLC and UHPLC instruments. The column efficiency performs typically 40% higher in comparison to fully porous particulate columns with same particle size.
Our Ascentis® Express C8 high-speed, high-performance liquid chromatography column is based on a superficially porous Fused-Core® particle design. The Fused-Core® particle provides a thin porous shell of high-purity silica surrounding a solid silica core. This particle design exhibits very high column efficiency due to the shallow diffusion paths. Three different particle sizes are available for your specific needs:
2.0 µm particles
Best Fused-Core UHPLC Column
An optimized solution for high-throughput small molecule analysis
2.7 µm particles
Fast HPLC on ANY System
A practical solution that delivers UHPLC performance from any HPLC
5.0 µm particles
The Lab Work-Horse Column
True plug and play solution for improving existing 3 or 5 µm fully porous particle HPLC columns