These 2 products are the same. LO4100 is the US version versus LO4200 is the International version.
LO4100
LOPAC®1280 - petite échelle
Synonyme(s) :
Library of Pharmacologically Active Compounds - small scale
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A propos de cet article
UNSPSC Code:
12352200
EC Number:
200-664-3
NACRES:
NA.77
Form:
liquid
Quality level:
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liquid
Quality Level
drug control
Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
shipped in
dry ice
storage temp.
−20°C
General description
Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).
LOPAC® 1280 is an extensively used library of pharmacologically active compounds. This library includes 1,280 marketed drugs, failed development candidates, and small molecules with well-characterized activities. LOPAC 1280 spans a broad molecular weight range, exhibits multiple mechanisms of action and interacts with a variety of biological receptors.[1]
Application
LOPAC® 1280 - Small Scale has been used:
- in sprouting assay to screen potential lymphangiogenic inhibitors and the signaling pathways involved in lymphangiogenesis[2][3]
- for identification of neuroactive compounds by measuring spontaneous activity within single zebrafish embryos by high-content screening assay[1]
- for high-throughput Screen for ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1; also known as CD39) and ecto-5′-nucleotidase (CD73) inhibitors[4]
Features and Benefits
Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:
- Apoptosis
- G Proteins & Cyclic Nucleotides
- Gene Regulation & Expression
- Ion Channels
- Lipid Signaling
- Multi-Drug Resistance
- Neurotransmission
- Phosphorylation
SDFile provided to construct a database containing:
- Structure
- Primary Name
- Secondary Name
- Pharmacological Activity
- Product Number
- Rack Position
Other Notes
For sale inside of the U.S. only. Customers outside the US should refer to Product Code LO4200.
Legal Information
LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany
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Danger
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2
Classe de stockage
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
188.6 °F
flash_point_c
87 °C
wgk
WGK 3
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Articles
Explore compound library screening options with our Pharmacologically Active Compounds portfolio.
Sara M Vliet et al.
Toxicology and applied pharmacology, 329, 241-248 (2017-06-18)
Spontaneous activity represents an early, primitive form of motor activity within zebrafish embryos, providing a potential readout for identification of neuroactive compounds. However, despite use as an endpoint in chemical screens around the world, the predictive power and limitations of
Roland E Kälin et al.
Blood, 114(5), 1110-1122 (2009-05-30)
Angiogenesis and lymphangiogenesis are essential for organogenesis but also play important roles in tissue regeneration, chronic inflammation, and tumor progression. Here we applied in vivo forward chemical genetics to identify novel compounds and biologic mechanisms involved in (lymph)angiogenesis in Xenopus
Miao Xu et al.
Nature medicine, 22(10), 1101-1107 (2016-08-30)
In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak and its link to microcephaly and other neurological conditions, we performed a drug repurposing screen of ∼6,000 compounds that included approved drugs, clinical trial drug
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| LO4100-1EA | 04061833967249 |
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What is the difference between the LOPAC1280 Products LO4100 and LO4200?
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Where can I find preparation instruction, storage and stability of the LOPAC 1280 - Small Scale Products LO4100 and LO4200?
1 answer-
The information is available in the datasheet of a similar product LO1280.
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What is the difference between the LOPAC®,1280 product numbers LO4100 and LO1280?
1 answer-
The compound per well in LO4100 is 25 ul at 10mM in DMSO versus 250 ul in the product LO1280
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Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 US approved?
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About 30% of the collection is made up of drugs approved for use in the US.
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Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 approved for therapeutic use?
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Although there are FDA approved drugs in the set, we market them based on their research application and not necessarily their therapeutic indications. All of the information we have is included on the CD that is received with the library. We do not include information from the Physician's Desk Reference.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Can I get a list of CAS numbers of the drugs sent with LOPAC 1280 - Small Scale Products LO4100 and LO4200?
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There is no CAS number list available.
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Is the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD shipped with the product?
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Yes, the CD is shipped with the product. If you do not receive it you should contact Sigma-Aldrich Technical Services at [email protected] or 1800-325-5832.
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What is on the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD?
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The CD contains the SDFile - provided to construct a database containing structure, primary name, secondary, Pharmacological Activity. Product number and Rack position.
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