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Merck

ACLY

ATP citrate lyase

Sinonimi:
ACL, ATPCL, CLATP
Specie:
ID UniProtKB:
ID gene:
  • Human(47) Summary: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(104112) ATP citrate lyase
  • Rat(24159) ATP citrate lyase
  • chicken(395373) ATP citrate lyase
  • naked mole-rat(101700349) ATP citrate lyase
  • domestic guinea pig(100714933) ATP citrate lyase
  • dog(607852) ATP citrate lyase
  • Horse(100053195) ATP citrate lyase
  • domestic cat(100422779) ATP citrate lyase
  • cow(511135) ATP citrate lyase
  • sheep(654404) ATP citrate lyase

Custom & Knockdown Gene Products

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-ACLY antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human, mouse, rat
Applicazione
immunofluorescence
immunohistochemistry

western blot
Anti-ACLY, clone 5F8D11 Antibody, clone 5F8D11, from mouse,
Reattività con
human, monkey, mouse
Applicazione
ELISA
flow cytometry

immunofluorescence

immunohistochemistry

western blot
Anti-ACLY Antibody, clone 1B16 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human, mouse, rat
Applicazione
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-ACLY antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Reattività con
human, mouse, rat
Applicazione
immunofluorescence
immunohistochemistry

western blot
Anti-ACLY antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human, mouse, rat
Applicazione
immunohistochemistry
western blot

Proteins

Numero di prodotto
Descrizione
Specie
ATP Citrate Lyase Active human, recombinant, expressed in baculovirus, ≥90% (SDS-PAGE),
Specie
human

esiRNA

Numero di prodotto
Descrizione
Specie
MISSION® esiRNA, targeting human ACLY,
Specie
human
MISSION® esiRNA, targeting mouse Acly,
Specie
mouse