CHEK1
checkpoint kinase 1
Sinonimi:
CHK1
Specie:
Human CHEK1 (1111), Mouse Chek1 (12649), Rat Chek1 (140583), naked mole-rat Chek1 (101701035), sheep CHEK1 (101111403), domestic guinea pig Chek1 (100719613), Zebrafish chek1 (393162), domestic cat CHEK1 (101083365), dog CHEK1 (609767), Horse CHEK1 (100064353)
ID UniProtKB:
ID gene:
- Human(1111) Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
- Mouse(12649) checkpoint kinase 1
- Rat(140583) checkpoint kinase 1
- naked mole-rat(101701035) checkpoint kinase 1
- sheep(101111403) checkpoint kinase 1
- domestic guinea pig(100719613) checkpoint kinase 1
- Zebrafish(393162) CHK1 checkpoint homolog (S. pombe)
- domestic cat(101083365) checkpoint kinase 1
- dog(609767) checkpoint kinase 1
- Horse(100064353) checkpoint kinase 1
- cow(513678) CHK1 checkpoint homolog (S. pombe)
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Antibodies
Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-Chk1 antibody, Mouse monoclonal, ~2 mg/mL, clone DCS-310, purified from hybridoma cell culture,
Reattività con
human
Applicazione
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
immunoprecipitation (IP)
microarray
western blot
Anti-phospho-Chk1 (pSer345) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry
immunohistochemistry
Anti-CHEK1 antibody produced in rabbit, affinity isolated antibody,
Reattività con
dog, horse, human, mouse, rabbit, rat
Applicazione
immunohistochemistry
western blot
western blot
Anti-CHK1 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
western blot
western blot
Anti-Chk1 Antibody, clone 2E14 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
canine, feline, human, monkey, mouse, porcine
Applicazione
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Numero di prodotto
Descrizione
Specie
Proteins
Numero di prodotto
Descrizione
Specie
CHK1 Protein, active, 10 µg, Active, N-terminal GST tagged, human full length CHK1, for use in Kinase Assays.,
Specie
human
CHK1, active, His tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Specie
human
CHK1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Specie
human
esiRNA
Numero di prodotto
Descrizione
Specie
Small Molecule - Substrate
Numero di prodotto
Descrizione
Specie
CHKtide (CHK1/CHK2 substrate peptide), CHKtide (CHK1/CHK2 substrate peptide) primarily used in Kinase Assays.,
Specie
human