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Merck

CHRM2

cholinergic receptor, muscarinic 2

Sinonimi:
HM2
Specie:
Human CHRM2 (1129), Mouse Chrm2 (243764), Rat Chrm2 (81645), Domestic Rabbit CHRM2 (100342878), naked mole-rat Chrm2 (101714286), chicken CHRM2 (418126), domestic guinea pig Chrm2 (100715343), dog CHRM2 (403858), cow CHRM2 (522170), domestic cat CHRM2 (101099790) ...Più
ID UniProtKB:
P08172, Q4VBK6, Q9P1X9
ID gene:
  • Human(1129) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(243764) cholinergic receptor, muscarinic 2, cardiac
  • Rat(81645) cholinergic receptor, muscarinic 2
  • Domestic Rabbit(100342878) cholinergic receptor, muscarinic 2
  • naked mole-rat(101714286) cholinergic receptor, muscarinic 2
  • chicken(418126) cholinergic receptor, muscarinic 2
  • domestic guinea pig(100715343) cholinergic receptor, muscarinic 2
  • dog(403858) cholinergic receptor, muscarinic 2
  • cow(522170) cholinergic receptor, muscarinic 2
  • domestic cat(101099790) cholinergic receptor, muscarinic 2
  • sheep(101102897) cholinergic receptor, muscarinic 2
  • sheep(100628317) cholinergic receptor, muscarinic 2

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Small Molecule - Agonist

Numero di prodotto
Descrizione
Specie
P6503
Pilocarpine hydrochloride, ≥99% (titration), powder,
Specie
human
A2251
Acetyl-β-methylcholine chloride, ≥98% (TLC), powder,
Specie
human
P6628
Pilocarpine nitrate salt, ≥98% (HPLC),
Specie
human
O100
Oxotremorine M, solid,
Specie
human
M104
(±)-Muscarine chloride hydrate, ≥98% (HPLC),
Specie
human

Small Molecule - Antagonist

Numero di prodotto
Descrizione
Specie
M105
Methoctramine hydrate, ≥97% (NMR), solid,
Specie
human
SML1102
Darifenacin hydrobromide, ≥98% (HPLC),
Specie
human
1485103
Oxybutynin chloride, United States Pharmacopeia (USP) Reference Standard,
Specie
human
O0288000
Oxybutynin hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Specie
human
1164200
Darifenacin hydrobromide, United States Pharmacopeia (USP) Reference Standard,
Specie
human

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
MAB367
Anticorpo anti-recettore muscarinico m2 per l′acetilcolina, clone M2-2-B3, clone M2-2-B3, Chemicon®, from rat,
Reattività con
human, mammals, monkey, rat
Applicazione
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
AB9452
Anti-Muscarinic Acetylcholine Receptor M2 Antibody, Chemicon®, from rabbit,
Reattività con
human
Applicazione
immunohistochemistry
WH0001129M1
Monoclonal Anti-CHRM2 antibody produced in mouse, clone 4B5, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
western blot

Small Molecule - Inhibitor

Numero di prodotto
Descrizione
Specie
A8404
Amitriptyline hydrochloride, ≥98% (TLC), powder,
Specie
human
D4526
Doxepin hydrochloride, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
Specie
human
H1512
Haloperidol, powder,
Specie
human, rat
51330
Harmaline, ≥95%,
Specie
human, rat

Small Molecule - Ligand

Numero di prodotto
Descrizione
Specie
A138
Aminobenztropine, solid,
Specie
human

Proteins

Numero di prodotto
Descrizione
Specie
HTS115M
ChemiSCREEN Membrane Preparation Recombinant Human M2 Muscarinic Acetylcholine Receptor, Human M2 GPCR membrane prepation for Radioligand binding Assays.,
Specie
human

esiRNA

Numero di prodotto
Descrizione
Specie
EHU120771
MISSION® esiRNA, targeting human CHRM2,
Specie
human