FDPS
farnesyl diphosphate synthase
Sinonimi:
FPPS, FPS
Specie:
Human FDPS (2224), Mouse Fdps (110196), Rat Fdps (83791), domestic cat FDPS (101086533), Horse FDPS (100063641), cow FDPS (281156), sheep FDPS (101119093), dog FDPS (480129), domestic guinea pig Fdps (100717025), naked mole-rat Fdps (101721614) ...Più
ID UniProtKB:
ID gene:
- Human(2224) Summary: This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
- Mouse(110196) farnesyl diphosphate synthetase
- Rat(83791) farnesyl diphosphate synthase
- domestic cat(101086533) farnesyl diphosphate synthase
- Horse(100063641) farnesyl diphosphate synthase
- cow(281156) farnesyl diphosphate synthase
- sheep(101119093) farnesyl diphosphate synthase
- dog(480129) farnesyl diphosphate synthase
- domestic guinea pig(100717025) farnesyl diphosphate synthase
- naked mole-rat(101721614) farnesyl diphosphate synthase
- Zebrafish(552997) farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
- chicken(425061) farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
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Antibodies
Numero di prodotto
Descrizione
Reattività con
Applicazione
KD-Validated Anti Farnesyl diphosphate synthase Antibody, clone 23GB1395, Rabbit Monoclonal, clone 23GB1395, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reattività con
human
Applicazione
flow cytometry
immunofluorescence
western blot
immunofluorescence
western blot
Anti-FDPS antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Numero di prodotto
Descrizione
Specie
Alendronate Sodium, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human