LDLR
low density lipoprotein receptor
Sinonimi:
FH, FHC, LDLCQ2
Specie:
Human LDLR (3949), Mouse Ldlr (16835), Rat Ldlr (300438), dog LDLR (100683160), cow LDLR (281276), Zebrafish ldlr (387529), domestic cat LDLR (101080362), naked mole-rat Ldlr (101703463), Domestic Rabbit LDLR (100009086), chicken LDLR (395103)
ID UniProtKB:
ID gene:
- Human(3949) Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
- Mouse(16835) low density lipoprotein receptor
- Rat(300438) low density lipoprotein receptor
- dog(100683160) low density lipoprotein receptor
- cow(281276) low density lipoprotein receptor
- Zebrafish(387529) low density lipoprotein receptor
- domestic cat(101080362) low density lipoprotein receptor
- naked mole-rat(101703463) low density lipoprotein receptor
- Domestic Rabbit(100009086) low density lipoprotein receptor
- chicken(395103) low density lipoprotein receptor
- domestic guinea pig(100724238) low density lipoprotein receptor
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Antibodies
Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-LDLR Antibody, clone C7, clone C7, from mouse,
Reattività con
bovine, human
Applicazione
western blot
Anti-LDLR antibody produced in rabbit, Ab1, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Anti-Low Density Lipoprotein Antibody, copper oxidized, serum, Chemicon®,
Reattività con
human
Applicazione
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Low Density Lipoprotein Antibody, HOCL oxidized, serum, Chemicon®,
Reattività con
human
Applicazione
ELISA
immunohistochemistry
immunohistochemistry
Anti-LDL Receptor Antibody, clone 2H7.1, clone 2H7.1, from mouse,
Reattività con
human
Applicazione
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot