MAP2K4
mitogen-activated protein kinase kinase 4
Sinonimi:
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
Specie:
Human MAP2K4 (6416), Mouse Map2k4 (26398), Rat Map2k4 (287398), domestic cat MAP2K4 (101086432), Domestic Rabbit MAP2K4 (100344852), chicken MAP2K4 (417312), dog MAP2K4 (489508), sheep MAP2K4 (101115045), Horse MAP2K4 (100073094), domestic guinea pig Map2k4 (100733674) ...Più
ID UniProtKB:
ID gene:
- Human(6416) Summary: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul 2008]
- Mouse(26398) mitogen-activated protein kinase kinase 4
- Rat(287398) mitogen activated protein kinase kinase 4
- domestic cat(101086432) mitogen-activated protein kinase kinase 4
- Domestic Rabbit(100344852) mitogen-activated protein kinase kinase 4
- chicken(417312) mitogen-activated protein kinase kinase 4
- dog(489508) mitogen-activated protein kinase kinase 4
- sheep(101115045) mitogen-activated protein kinase kinase 4
- Horse(100073094) mitogen-activated protein kinase kinase 4
- domestic guinea pig(100733674) mitogen-activated protein kinase kinase 4
- naked mole-rat(101705822) mitogen-activated protein kinase kinase 4
- cow(526469) mitogen-activated protein kinase kinase 4
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Antibodies
Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-MAP2K4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reattività con
human
Applicazione
immunofluorescence
western blot
western blot
Anti-MAP2K4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
immunofluorescence
western blot
western blot
Anti-phospho-SEK1/MKK4/JNKK1 (pSer257) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry
immunohistochemistry
Anti-Phospho-MAP2K4-S257 antibody produced in rabbit, ,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot
Anti-Phospho-MAP2K4-T261 antibody produced in rabbit, ,
Reattività con
human, mouse, rat
Applicazione
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Numero di prodotto
Descrizione
Specie
Proteins
Numero di prodotto
Descrizione
Specie
MKK4/SKK1 Protein, active, 10 µg, Active, N-terminal GST tagged, murine MKK4 residues 34-end, for use in Kinase Assays.,
Specie
mouse
MKK4/SKK1 Protein, inactive, 50 g, Unactive, recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an N-terminal GST-tag, for use in Kinase Assays.,
Specie
mouse