MAP3K5
mitogen-activated protein kinase kinase kinase 5
Sinonimi:
ASK1, MAPKKK5, MEKK5
Specie:
Human MAP3K5 (4217), Mouse Map3k5 (26408), Rat Map3k5 (365057), chicken MAP3K5 (421688), domestic cat MAP3K5 (101082912), dog MAP3K5 (476215), Zebrafish map3k5 (555703), sheep MAP3K5 (101121018), cow MAP3K5 (537380), Horse MAP3K5 (100073186) ...Più
ID UniProtKB:
ID gene:
- Human(4217) Summary: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
- Mouse(26408) mitogen-activated protein kinase kinase kinase 5
- Rat(365057) mitogen-activated protein kinase kinase kinase 5
- chicken(421688) mitogen-activated protein kinase kinase kinase 5
- domestic cat(101082912) mitogen-activated protein kinase kinase kinase 5
- dog(476215) mitogen-activated protein kinase kinase kinase 5
- Zebrafish(555703) mitogen-activated protein kinase kinase kinase 5
- sheep(101121018) mitogen-activated protein kinase kinase kinase 5
- cow(537380) mitogen-activated protein kinase kinase kinase 5
- Horse(100073186) mitogen-activated protein kinase kinase kinase 5
- naked mole-rat(101712051) mitogen-activated protein kinase kinase kinase 5
- domestic guinea pig(100722979) mitogen-activated protein kinase kinase kinase 5
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Antibodies
Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti MAP3K5 Antibody, clone 23GB2060, Rabbit Monoclonal, clone 23GB2060, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reattività con
human
Applicazione
flow cytometry
immunofluorescence
western blot
immunofluorescence
western blot
Anti-phospho-ASK1 (pSer966) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-ASK1 (pSer83) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho MEKK5, (Thr845), clone PA214 Antibody, clone PA214, from rabbit,
Reattività con
human, mouse
Applicazione
western blot
Anti-MAP3K5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reattività con
human
Applicazione
immunohistochemistry