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Merck

PPARG

peroxisome proliferator-activated receptor gamma

Sinonimi:
CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
Specie:
ID UniProtKB:
ID gene:
  • Human(5468) Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(19016) peroxisome proliferator activated receptor gamma
  • Rat(25664) peroxisome proliferator-activated receptor gamma
  • Zebrafish(557037) peroxisome proliferator activated receptor gamma
  • chicken(373928) peroxisome proliferator-activated receptor gamma
  • cow(281993) peroxisome proliferator-activated receptor gamma
  • naked mole-rat(101711078) peroxisome proliferator-activated receptor gamma
  • Goat(100861309) peroxisome proliferator-activated receptor gamma
  • domestic cat(100049014) peroxisome proliferator-activated receptor gamma
  • domestic cat(101095161) peroxisome proliferator-activated receptor gamma
  • domestic guinea pig(100729138) peroxisome proliferator-activated receptor gamma
  • sheep(443513) peroxisome proliferator-activated receptor gamma
  • dog(403606) peroxisome proliferator-activated receptor gamma

Custom & Knockdown Gene Products

Small Molecule - Activator

Numero di prodotto
Descrizione
Specie
Ciglitizone, ≥98% (HPLC),
Specie
mouse, human
2-(p-Chlorophenoxy)-2-methylpropionic acid, 97%,
Specie
mouse, human
WY-14643, ,
Specie
rat, human, mouse
Bezafibrate, ≥98%, solid,
Specie
mouse, human

Small Molecule - Agonist

Numero di prodotto
Descrizione
Specie
Rosiglitazone, ≥98% (HPLC),
Specie
human
Pioglitazone hydrochloride, ≥98% (HPLC),
Specie
human
Pioglitazone, ,
Specie
human
Pioglitazone hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human
Pioglitazone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Specie
human

Small Molecule - Antagonist

Numero di prodotto
Descrizione
Specie
GW9662, >98% (HPLC),
Specie
human
Troglitazone, ≥98% (HPLC),
Specie
human
Ciglitizone, ≥98% (HPLC),
Specie
mouse, human
GW0742, ≥98% (HPLC),
Specie
human
cis-5,8,11,14,17-Eicosapentaenoic acid, ≥99%,
Specie
mouse, human, rat

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-PPAR gamma antibody produced in rabbit, ,
Reattività con
human, mouse, rat
Applicazione
immunofluorescence
immunohistochemistry

western blot
Anti-phospho-PPAR-γ (pSer112) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
western blot
Anticorpo anti-PPAR-gamma, from rabbit, purified by affinity chromatography,
Reattività con
canine, feline, human, monkey, mouse, porcine
Applicazione
immunocytochemistry
western blot
Anti-PPAR-γ antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry

western blot
Anti-PPARG (AB1) antibody produced in rabbit, IgG fraction of antiserum,
Reattività con
dog, guinea pig, horse, human, mouse, rabbit, rat
Applicazione
immunohistochemistry
western blot

Proteins

Numero di prodotto
Descrizione
Specie
PPAR γ, ligand binding domain (204-477), GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Specie
human
PPAR, γ human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Specie
human

esiRNA

Numero di prodotto
Descrizione
Specie
MISSION® esiRNA, targeting human PPARG,
Specie
human
MISSION® esiRNA, targeting mouse Pparg,
Specie
mouse