PYGL
phosphorylase, glycogen, liver
Sinonimi:
GSD6
Specie:
Human PYGL (5836), Mouse Pygl (110095), Rat Pygl (64035), sheep PYGL (554320), chicken PYGL (378909), Horse PYGL (100066726), Zebrafish pygl (493916), naked mole-rat Pygl (101723998), cow PYGL (505472), dog PYGL (403738) ...Più
ID UniProtKB:
ID gene:
- Human(5836) Summary: This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]
- Mouse(110095) liver glycogen phosphorylase
- Rat(64035) phosphorylase, glycogen, liver
- sheep(554320) phosphorylase, glycogen, liver
- chicken(378909) phosphorylase, glycogen, liver
- Horse(100066726) phosphorylase, glycogen, liver
- Zebrafish(493916) phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)
- naked mole-rat(101723998) phosphorylase, glycogen, liver
- cow(505472) phosphorylase, glycogen, liver
- dog(403738) phosphorylase, glycogen, liver
- domestic cat(101089364) phosphorylase, glycogen, liver
- domestic guinea pig(100721433) phosphorylase, glycogen, liver
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-PYGL antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PYGL antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PYGL antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
western blot
Small Molecule - Inhibitor
Numero di prodotto
Descrizione
Specie
esiRNA
Numero di prodotto
Descrizione
Specie