This product is tested for suitability as a 6.5 kDa molecular weight marker. The activity of the material is not determined. See the link below to review other Aprotinin products that may more suitable:
https://www.sigmaaldrich.com/substance/aprotininfrombovinelung6511449087701
A3886
Aprotinin
powder
Synonym(s):
BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)
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About This Item
Empirical Formula (Hill Notation):
C284H432N84O79S7
CAS Number:
Molecular Weight:
6511.44
EC Number:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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Product Name
Aprotinin from bovine lung,
biological source
bovine lung
Quality Level
form
powder
mol wt
~6,500
packaging
vial of 15 mg
solubility
glycerol: 3 mg/mL, clear, colorless (equilibration buffer containing 5% glycerol)
UniProt accession no.
storage temp.
−20°C
SMILES string
S1SCC2NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C5NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C9N(CCC9)C(=O)CNC(=O)C(NC(=O)C(NC(=O)C%11N(CCC%11)C(=O
InChI key
ZPNFWUPYTFPOJU-UHFFFAOYSA-N
Gene Information
cow ... PTI(404172)
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1 of 4
This Item | 10820 | A3428 | A4529 |
|---|---|---|---|
| biological source bovine lung | biological source bovine lung | biological source bovine lung | biological source bovine lung |
| Gene Information cow ... PTI(404172) | Gene Information cow ... PTI(404172) | Gene Information cow ... PTI(404172) | Gene Information cow ... PTI(404172) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| form powder | form crystalline (fine) | form lyophilized powder | form lyophilized powder |
| solubility glycerol: 3 mg/mL, clear, colorless (equilibration buffer containing 5% glycerol) | solubility phosphate buffer: 5 mg/mL, clear, colorless (PH 7.6 (70 mm phosphate)) | solubility H2O: 5 mg/mL | solubility H2O: >10 mg/mL |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
Application
Aprotinin is largely used as an inhibitor of trypsin.
Gel filtration molecular weight marker
Biochem/physiol Actions
Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.
Unit Definition
One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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