P8861

Pyrrolnitrin from Pseudomonas cepacia

≥98% (HPLC), solid

• Synonym(s): 3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole
• CAS Number: 1018-71-9
• EC Number: 213-812-7
• MDL number: MFCD00865605
• UNSPSC Code: 12352200
• PubChem Substance ID: 24898985
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: solid
• antibiotic activity spectrum: fungi
• Mode of action: enzyme | inhibits
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: [O-][N+](=O)c1c(Cl)cccc1-c2c[nH]cc2Cl
• InChI: 1S/C10H6Cl2N2O2/c11-8-3-1-2-6(10(8)14(15)16)7-4-13-5-9(7)12/h1-5,13H
• InChI key: QJBZDBLBQWFTPZ-UHFFFAOYSA-N

Description

Specificity

The purified antibiotic has strong antifungal activity and is less efficient against bacteria or yeast.

Application

Pyrrolnitrin from Pseudomonas cepacia has been used as a standard in the detection of pyrrolnitrin in Serratia marcescens cell culture extract.[1]

Biochem/physiol Actions

Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis.

Pyrrolnitrin is a metabolite, produced by Pseudomonas sp.[2]

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves