Protein labeling and modification

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Methods and Matrices for Mass Spectrometry of Glycans

Glycosylation is known to have profound influence on various physiochemical, cellular and biological functions of proteins. Alterations in this modification are known to affect the immune system and have been associated with various pathological states such as cancer, rheumatoid arthritis

Signal Peptide Optimization: Effect On Recombinant Monoclonal IgG Productivity, Product Quality And Antigen-Binding Affinity

A signal peptide is a 5-30 amino acid (aa) peptide present at the N-terminus of secretory proteins.

Designing Peptides

This summary highlights some important points that should be considered in the design of a peptide. If you would like help with peptide design, our technical support department can assist you

Ni-NTA-Atto Conjugates

Ni-NTA-Atto conjugates provide specific and highly sensitive detection of His-tagged fusion proteins.

Introduction to Target Identification with Hyas and Dione Kits

In cases where photoaffinity labeling (PAL) probes are ineffective, Hyas and Dione Kits provide an effective method for small molecule identification by using an Iridium photocatalyst tethered to the molecule under investigation.

Enzymes for Antibody Characterization

Antibodies now make up the fastest growing category of therapeutic drugs

Peptide Modifications: N-Terminal, Internal, and C-Terminal

Near-infrared (NIR) Fluorescence Dyes

NIR Fluorescence Dyes

Mass Spectrometry

What is Mass Spectrometry or MS? What is it used for and how does it work? Read this detailed article with diagrams and example graphs to understand how to use mass spec in your research.

Proline Derivatives and Analogs

Proline analogues are promising candidates for tuning the biological, pharmaceutical, or physicochemical properties of naturally occuring, as well as de novo designed, linear, and, cyclic peptides.

Unnatural Amino Acids for Peptide Synthesis

Unnatural amino acids, the non-proteinogenic amino acids that either occur naturally or are chemically synthesized, are becoming more and more important as tools for modern drug discovery research.

N-Linked Glycans Overview

N-linked glycosylation, modification, and degradation

Glycoprotein Deglycosylation

Information about Glycoprotein deglycosylation. The diversity of oligosaccharide structures, both O-linked and N-linked, often results in heterogeneity in the mass and charge of glycoproteins.

Protein Deglycosylation

Protein Deglycosylation: PNGase F Proteomics Grade, Native Protein Deglycosylation Kit, Enzymatic Protein Deglycosylation Kit, and ProteoProfile Trypsin In-Gel Digest Kit

Improving Glycoform Coverage for Mucin Prep

Human Protein Atlas uses A-431, U-251 MG, and U-205 cell lines with Prestige Antibodies for organelle mapping.

Biotinylated Peptides

Streptavidin HC plates with high-capacity coating offer selective binding, reducing non-specificity.

Post Translational Modification

Protein modifications are crucial for disease study. Analysis methods are key.

Designing Peptides

Consider sequence length, solubility, and stability when designing peptides for custom synthesis.

Glycoprofile™ Labeling Kits

Glycoprofile Labeling Kits efficiently label glycans for glycan analysis, offering flexibility in choice of labeling.

Strategies for Deglycosylating N-Linked Glycans

Explore strategies for releasing N-linked glycans with PNGase F, PNGase A & native & sequential deglycosylation with endoglycosidases & exoglycosidases.

Introduction to Proximity Labeling

Novel method tags antibodies with photoreactive iridium for membrane protein labeling.

Peptidoglycan Structure and Biosynthesis

Peptidoglycan structure: alternating GlcNAc and N-acetylmuramic acid cross-linked to peptides form the basic backbone.

O Linked Glycans

O-Linked glycans attachment to peptides involves various residues, particularly GalNAc, known as mucin-type glycans.

Phosphorylation Basics

Explore phosphorylation types converting ADP to ATP, comparing oxidative and substrate-level phosphorylation with explanatory diagrams.

Glycosyltransferases: Tools for Synthesis and Modification of Glycans

Explore tools for glycosyltransferase synthesis and modification of glycans, such as glycosyltransferases and nucleotide sugar donors.

Phosphorylation Analysis Tools

Phosphorylation's role in cell signaling pathways and protein modification.

Gold Nanoparticles: Properties and Applications

Gold (Au) nanoparticles have tunable optical and electronic properties and are used in a number of applications including photovoltaics, sensors, drug delivery & catalysis.

Peptide Coupling Reagents Guide

Novabiochem® coupling reagents for in situ activation are fast-reacting and compatible with various amino acids.

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Glycosylphosphatidylinisotol-anchored Glycoproteins Overview

Glycosylphosphatidylinisotol- (GPI) anchored proteins have been identified throughout a broad range of eukaryotic species ranging from humans to insects, yeasts, bacteria, and fungi, suggesting that they are an ancient modification.

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