[Saltar al contenido](https://www.sigmaaldrich.com#main-content) [](https://www.sigmaaldrich.com/CL/es) Productos Carrito0 CLES Productos [Inicio de sesión / Registrarse](https://www.sigmaaldrich.com/oidc-sign-in) [Búsqueda de pedido](https://www.sigmaaldrich.com/CL/es/order-lookup) [Pedido rápido](https://www.sigmaaldrich.com/CL/es/quick-order) Carrito0 [Home](https://www.sigmaaldrich.com/CL/en)[Applications](https://www.sigmaaldrich.com/CL/en/applications)[Materials Science and Engineering](https://www.sigmaaldrich.com/CL/en/applications/materials-science-and-engineering) Tissue Engineering # Tissue Engineering  Tissue engineering and regenerative medicine are interdisciplinary fields aimed at developing biological substitutes to restore, maintain, improve tissue function, or replace diseased and damaged tissues. Both hard tissues (e.g., bone, cartilage) and soft tissues (e.g., skin, cardiovascular valves) can be fabricated by tissue engineering. Cells, scaffolds, and growth-stimulating signals are three key components for engineering tissue substitutes. Whereas tissue engineering cultures tissue *in vitro*, regenerative medicine combines tissue engineering with other strategies, including cell-based therapy, gene therapy, and immunomodulation, to induce *in vivo* tissue regeneration. Biomimetic tissue constructs are also developed as *in vitro* models for drug screening and disease modeling.   Tissue engineering involves cultivating new tissue in the lab by combining scaffolds, native tissue cells, and bioactive molecules to emulate the biological processes of the body.  * * * ## Related Products Slide 1 of 11 1 of 3 [ \ Sigma-Aldrich \ 901701 \ Poly(ethylene glycol)-*block*-poly(propylene glycol)-*block*-poly(ethylene glycol) diacrylate](https://www.sigmaaldrich.com/CL/es/product/aldrich/901701) Vista rápida [ \ Sigma-Aldrich \ P2443 \ Pluronic® F-127](https://www.sigmaaldrich.com/CL/es/product/sigma/p2443) Vista rápida [ \ Sigma-Aldrich \ 719781 \ Carbon nanofibers](https://www.sigmaaldrich.com/CL/es/product/aldrich/719781) Vista rápida [ \ Sigma-Aldrich \ 906808 \ Water-soluble TPO based nanoparticle photoinitiator](https://www.sigmaaldrich.com/CL/es/product/aldrich/906808) Vista rápida [ \ Sigma-Aldrich \ 906816 \ Water-soluble TPO based nanoparticle photoinitiator](https://www.sigmaaldrich.com/CL/es/product/aldrich/906816) Vista rápida [ \ Sigma-Aldrich \ 900889 \ Lithium phenyl-2,4,6-trimethylbenzoylphosphinate](https://www.sigmaaldrich.com/CL/es/product/aldrich/900889) Vista rápida [ \ Sigma-Aldrich \ 900741 \ Gelatin methacryloyl](https://www.sigmaaldrich.com/CL/es/product/aldrich/900741) Vista rápida [ \ Sigma-Aldrich \ 900622 \ Gelatin methacryloyl](https://www.sigmaaldrich.com/CL/es/product/aldrich/900622) Vista rápida [ \ Sigma-Aldrich \ 901757 \ Low endotoxin gelatin from porcine skin](https://www.sigmaaldrich.com/CL/es/product/aldrich/901757) Vista rápida [ \ Sigma-Aldrich \ W201502 \ Alginato de sodio](https://www.sigmaaldrich.com/CL/es/product/aldrich/w201502) Vista rápida [ \ Sigma-Aldrich \ 900721 \ Bovine fibrillar collagen solution](https://www.sigmaaldrich.com/CL/es/product/aldrich/900721) Vista rápida * * * ## Featured Categories [](https://www.sigmaaldrich.com/CL/en/products/materials-science/biomedical-materials/polyethylene-glycol) [Polyethylene Glycol (PEGs and PEOs)](https://www.sigmaaldrich.com/CL/en/products/materials-science/biomedical-materials/polyethylene-glycol) Discover our selection of polyethylene glycol (PEGs) and PEG derivatives in a wide range of molecular weights for all your PEGylation needs and applications. 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[Shop Products](https://www.sigmaaldrich.com/CL/en/integrated-offerings/biopharma-4-0/process-analytical-technology) * * * Overview Related Articles & Protocols Support Tissue scaffolds are analogous to the functions of extracellular matrix (ECM) in native tissues. Tissue scaffolds provide a structural and physical environment for cells to grow, migrate, and respond to signals; mechanical properties to the resulting tissue; and bioactive cues to the residing cells for activity regulation. Three major approaches have evolved to develop tissue scaffolds that mimic native ECM functions: - Seeding cells on pre-made porous scaffolds from degradable biomaterials, including decellularized ECM from allogenic and xenogenic tissues, natural polymers, bioglasses, and synthetic polymers - Cell sheet engineering by seeding cells on thermo-responsive polymer-coated culture dishes and detaching the polymer sheet once the cells become confluent - Cell encapsulation in a hydrogel matrix made of natural or synthetic polymers, such as bioinks, in 3D bioprinting [](https://www.sigmaaldrich.com/documents-search) [Looking for More Specific Information?](https://www.sigmaaldrich.com/documents-search) Visit our document search for data sheets, certificates and technical documentation. [Find Documents](https://www.sigmaaldrich.com/documents-search) [Shop All Products](https://www.sigmaaldrich.com/search/tissue-engineering?focus=products&page=1&perpage=30&sort=relevance&term=Tissue%20Engineering&type=product) ## Related Articles - [RAFT: Choosing the Right Agent to Achieve Controlled Polymerization](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/materials-science-and-engineering/polymer-synthesis/raft-polymerization) Find reversible addition–fragmentation chain transfer(RAFT) polymerization process, classes of RAFT agents & applications. - [3D/4D Printing Technologies](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/materials-science-and-engineering/3d-printing/3d-and-4d-printing-technologies) Three-dimensional printing technology applications range from personal tools to aerospace equipment. - [Graphene Inks for Electronics](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/materials-science-and-engineering/3d-printing/graphene-inks-for-printed-electronics) Functional materials for printed electronics applications enable flexible displays, RFID tags, and biomedical sensors. - [Photocrosslinkable Hydrogels for 3D Cell Culture](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/cell-culture-and-cell-culture-analysis/3d-cell-culture/photocrosslinked-hydrogels) Methacrylated hydrogels enable 3D cell culture scaffolds and bioprinting using light crosslinking. - [Preparation & Staining of 3D Printed Tissues & Scaffolds](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/materials-science-and-engineering/3d-bioprinting/3d-printing-stains) Three-dimensional (3D) printing of biological tissue is rapidly becoming an integral part of tissue engineering. - [See All (37)](https://www.sigmaaldrich.com/CL/en/search/facet-search?focus=sitecontent&term=facet-search) ### Find More Articles and Protocols Enter Keywords Search ## How Can We Help In case of any questions, please submit a [customer support request](https://www.sigmaaldrich.com/CL/en/support/customer-support) or talk to our customer service team: Email [[email protected]](mailto:[email protected]) or call +1 (800) 244-1173 ## Additional Support - [Chromatogram Search](https://www.sigmaaldrich.com/chromatogram-search) Use the Chromatogram Search to identify unknown compounds in your sample. - [Calculators & Apps](https://www.sigmaaldrich.com/CL/en/support/calculators-and-apps) Web Toolbox - science research tools and resources for analytical chemistry, life science, chemical synthesis and materials science. - [Customer Support Request](https://www.sigmaaldrich.com/CL/en/support/customer-support) Customer support including help with orders, products, accounts, and website technical issues. - [FAQ](https://maestro.my.site.com/knowledgeportal/s/) Explore our Frequently Asked Questions for answers to commonly asked questions about our products and services. __Featured Articles__ [RAFT: Choosing the Right Agent to Achieve Controlled Polymerization](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/materials-science-and-engineering/polymer-synthesis/raft-polymerization) Find reversible addition–fragmentation chain transfer(RAFT) polymerization process, classes of RAFT agents & applications. [3D/4D Printing Technologies](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/materials-science-and-engineering/3d-printing/3d-and-4d-printing-technologies) Three-dimensional printing technology applications range from personal tools to aerospace equipment. [Graphene Inks for Electronics](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/materials-science-and-engineering/3d-printing/graphene-inks-for-printed-electronics) Functional materials for printed electronics applications enable flexible displays, RFID tags, and biomedical sensors. [Photocrosslinkable Hydrogels for 3D Cell Culture](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/cell-culture-and-cell-culture-analysis/3d-cell-culture/photocrosslinked-hydrogels) Methacrylated hydrogels enable 3D cell culture scaffolds and bioprinting using light crosslinking. * * * __Featured Articles__ [RAFT: Choosing the Right Agent to Achieve Controlled Polymerization](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/materials-science-and-engineering/polymer-synthesis/raft-polymerization) Find reversible addition–fragmentation chain transfer(RAFT) polymerization process, classes of RAFT agents & applications. [3D/4D Printing Technologies](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/materials-science-and-engineering/3d-printing/3d-and-4d-printing-technologies) Three-dimensional printing technology applications range from personal tools to aerospace equipment. [Graphene Inks for Electronics](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/materials-science-and-engineering/3d-printing/graphene-inks-for-printed-electronics) Functional materials for printed electronics applications enable flexible displays, RFID tags, and biomedical sensors. [Photocrosslinkable Hydrogels for 3D Cell Culture](https://www.sigmaaldrich.com/CL/en/technical-documents/technical-article/cell-culture-and-cell-culture-analysis/3d-cell-culture/photocrosslinked-hydrogels) Methacrylated hydrogels enable 3D cell culture scaffolds and bioprinting using light crosslinking. Arriba __Inicie sesión para continuar.__ Para seguir leyendo, inicie sesión o cree una cuenta. Iniciar sesión__¿No tiene una cuenta?__Registrar An unknown error has occured. - Español - ES - English - EN [Más información](https://www.sigmaaldrich.com)