DL-Ephedrine hydrochloride

Name: DL-Ephedrine hydrochloride
Brand: ALDRICH

99%

Synonym(s):

(±)-2-Ephedrinium hydrochloride, (±)-Ephedrine hydrochloride, DL-erythro-Ephedrine hydrochloride

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About This Item

Linear Formula:

C₆H₅CH(OH)CH(CH₃)NHCH₃ · HCl

CAS Number:

134-71-4

Molecular Weight:

201.69

NACRES:

NA.22

PubChem Substance ID:

24857224

UNSPSC Code:

12352100

EC Number:

205-153-9

MDL number:

MFCD00012626

Key Documents

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Product Name

DL-Ephedrine hydrochloride, 99%

InChI key

BALXUFOVQVENIU-GHXDPTCOSA-N

InChI

1S/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10-;/m1./s1

SMILES string

Cl.CN[C@H](C)[C@@H](O)c1ccccc1

assay

99%

form

solid

mp

188-190 °C

solubility

H₂O: soluble 5%, clear, colorless

functional group

amine
hydroxyl
phenyl

Quality Level

100

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Show Differences

1 of 4

This Item	A7256	E4642	E0300000
Sigma-Aldrich 285749 DL-Ephedrine hydrochloride	Sigma-Aldrich A7256 DL-Norepinephrine hydrochloride	Sigma-Aldrich E4642 (±)-Epinephrine hydrochloride	E0300000 Ephedrine hydrochloride
assay 99%	assay ≥97% (TLC)	assay -	assay -
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level -
solubility H₂O: soluble 5%, clear, colorless	solubility water: soluble 50 mg/mL, clear to slightly hazy, faintly yellow to brownish-yellow	solubility H₂O: 50 mg/mL	solubility -
mp 188-190 °C	mp -	mp -	mp 216-220 °C (lit.)
form solid	form crystalline	form -	form -
functional group amine	functional group -	functional group -	functional group -

Application

Ephedrine hydrochloride was used in the control of the inflammatory response. It was also used to treat hypotension caused by either anesthesia or overdose of antihypertensive drugs[1].

General description

Ephedrine hydrochloride is an active α- and β-adrenergic agonist[2]. It has also been reported to be effective in treating daytime urinary incontinence in children.[3]

pictograms

GHS07

signalword

Warning

hcodes

H302,H317,H412

pcodes

P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Skin Sens. 1B

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway.

Yuejuan Zheng et al.

Cellular & molecular immunology, 10(4), 330-337 (2013-04-23)

Approaches for controlling inflammatory responses and reducing the mortality rate of septic patients remain clinically ineffective; new drugs need to be identified that can induce anti-inflammatory responses. Ephedrine hydrochloride (EH) is a compound that is widely used in cardiovascular diseases

Ephedrine hydrochloride: novel use in the management of resistant non-neurogenic daytime urinary incontinence in children.

Neil Featherstone et al.

Journal of pediatric urology, 9(6 Pt A), 915-918 (2013-01-22)

To determine whether the adrenoceptor agonist, ephedrine hydrochloride, is an effective treatment for resistant non-neurogenic daytime urinary incontinence in children. From 2000 to 2010, eighteen children with resistant non-neurogenic daytime urinary incontinence were treated with oral ephedrine hydrochloride at our

Ephedrine hydrochloride protects mice from LPS challenge by promoting IL-10 secretion and inhibiting proinflammatory cytokines.

Yuejuan Zheng et al.

International immunopharmacology, 13(1), 46-53 (2012-03-27)

Sepsis and its derivative endotoxic shock are still serious conditions with high mortality in the intensive care unit. The mechanisms that ensure the balance of proinflammatory cytokines and anti-inflammatory cytokine production are of particular importance. As an active α- and

Development and validation of a hydrophilic interaction liquid chromatography with tandem mass spectrometry method for the simultaneous detection and quantification of etilefrine and oxilofrine in equine blood plasma and urine.

Noel Kong et al.

Journal of separation science, 37(21), 3015-3023 (2014-08-22)

A sensitive hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry method was developed and validated for the simultaneous detection and quantification of etilefrine and oxilofrine in equine blood plasma and urine. The method is highly sensitive and specific with

Questions

1–2 of 2 Questions

Anonymous

6 months ago

How can I determine the shelf life / expiration / retest date of this product?

1 answer
1. Technical Support
  
  6 months ago
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
  Helpful?
Anonymous

11 months ago

How is shipping temperature determined? And how is it related to the product storage temperature?

1 answer
1. Technical Support
  
  11 months ago
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
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